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> Protein (NX_P04196)
Protein (NX_P04196)
Protein
Gene SymbolHRG to neXtProt (NX_P04196)
DescriptionHistidine-rich glycoprotein
Chromosome3
Location3q27.3 (186378005 ~ 186396029) to Ensembl
Sequene Features : Isoforms 1, Variants 117, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of endothelial cell chemotaxis
.positive regulation of blood vessel remodeling
.negative regulation of vascular endothelial growth factor signaling pathway
  + 27 more...
.metal ion binding
.heparan sulfate proteoglycan binding
.heme binding
  + 6 more...
.blood microparticle
.extracellular exosome
.phagolysosome membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 117 9
2014-09-19protein level
1 92 9
2014-05-27protein level
1 92 9
2014-02-25protein level
1 91 9
2013-12-09protein level
1 74 9
2013-11-01protein level
1 73 9
2013-09-12protein level
1 73 9
2013-08-17protein level
1 73 9
2013-07-15protein level
1 58 9
2013-06-11protein level
1 58 9
2013-02-12protein level
1 41 9
2012-12-20protein level
1 41 9
2012-10-30protein level
1 48 9
2012-10-07protein level
1 48 9
2012-08-24protein level
1 46 9
2012-07-28protein level
1 45 9
2012-06-08protein level
1 45 9
2012-05-07protein level
1 36 9
2012-04-10protein level
1 36 9
2012-01-13protein level
1 22 9
2011-12-20protein level
1 22 9
2011-11-11protein level
1 22 9
2011-08-23protein level
1 22 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P04196-1
24 0 0 59540.6986
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3915012,EBI-947779 RCHY1  
  .error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
embryonic tissue4
kidney37
liver530
lung2
mammary gland52
thymus12
Health State
TissuesTPM*
normal39
liver tumor354
Developmental Stage
TissuesTPM*
adult41
fetus66
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
kidney20.8
liver2162.3
Tissues
TissuesExpression level
adrenal glandLow
bone marrowLow
cervix, uterineLow
endometrium 2Low
heart muscleLow
kidneyLow
liverMedium
oral mucosaLow
prostateLow
skin 1Low
testisLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*142640, gene) Histidine-rich glycoprotein; HRGOMIM
2(#613116, phenotype) Thrombophilia due to histidine-rich glycoprotein deficiency; THPH11OMIM


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