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> Protein (NX_P04198)
Protein (NX_P04198)
Protein
Gene SymbolMYCN to neXtProt (NX_P04198)
DescriptionN-myc proto-oncogene protein
Chromosome2
Location2p24.3 (16080686 ~ 16087129) to Ensembl
Sequene Features : Isoforms 1, Variants 53, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of reactive oxygen species metabolic process
.branching morphogenesis of an epithelial tube
.negative regulation of astrocyte differentiation
  + 8 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
.chromatin
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 53 2
2014-09-19protein level
1 41 2
2014-05-27protein level
1 41 4
2014-02-25protein level
1 40 4
2013-12-09protein level
1 35 4
2013-11-01protein level
1 34 4
2013-09-12protein level
1 34 4
2013-08-17protein level
1 34 4
2013-07-15protein level
1 23 4
2013-06-11protein level
1 23 4
2013-02-12protein level
1 15 4
2012-12-20protein level
1 15 4
2012-10-30protein level
1 17 4
2012-10-07protein level
1 17 4
2012-08-24protein level
1 14 4
2012-07-28protein level
1 14 4
2012-06-08protein level
1 16 4
2012-05-07protein level
1 8 4
2012-04-10protein level
1 8 4
2012-01-13protein level
1 5 4
2011-12-20protein level
1 5 4
2011-11-11protein level
1 5 4
2011-08-23protein level
1 5 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P04198-1
17 0 1 49530.6684
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-878369,EBI-448680 AURKA  
  .neuron projection extension
.positive regulation of oocyte maturation
.negative regulation of spindle checkpoint
  + 21 more...
.histone serine kinase activity
.protein kinase binding
.ATP binding
  + 3 more...
.meiotic spindle
.mitotic spindle
.spindle midzone
  + 14 more...
2 EBI-878369,EBI-751711 MAX  
  .cellular response to peptide hormone stimulus
.retina development in camera-type eye
.neuron apoptotic process
  + 6 more...
.sequence-specific DNA binding
.transcription coactivator activity
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
.MLL1 complex
.dendrite
.PML body
  + 3 more...
3 EBI-878369,EBI-372942 NMI  
  .regulation of nucleic acid-templated transcription
.JAK-STAT cascade
.inflammatory response
.transcription from RNA polymerase II promoter
.transcription cofactor activity .cytoplasm
.nucleoplasm
4 EBI-878369,EBI-625922 CDKN2A  
  .negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of protein targeting to mitochondrion
.negative regulation of proteolysis involved in cellular protein catabolic process
  + 33 more...
.MDM2/MDM4 family protein binding
.ubiquitin-protein transferase inhibitor activity
.transcription factor binding
  + 2 more...
.protein complex
.mitochondrion
.nucleolus
  + 2 more...
5 EBI-878369,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain87
embryonic tissue98
eye148
heart44
kidney37
liver4
lung44
muscle65
ovary68
placenta21
thymus12
uterus4
Health State
TissuesTPM*
normal18
germ cell tumor53
glioma186
kidney tumor43
lung tumor116
ovarian tumor52
primitive neuroectodermal tumor of the CNS755
retinoblastoma646
soft tissue/muscle tissue tumor55
uterine tumor11
Developmental Stage
TissuesTPM*
adult4
embryoid body28
blastocyst146
fetus30
infant170
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
cerebral cortex2.8
duodenum1.2
kidney3
lymph node1.1
ovary3.6
placenta6.7
stomach3.3
testis3.1
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(#164280, phenotype) Feingold syndrome 1; FGLDS1OMIM
2(*164840, gene) V-myc avian myelocytomatosis viral-related oncogene, neuroblastoma-derived;OMIM
3neuroblastomaCGP


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