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> Protein (NX_P04259)
Protein (NX_P04259)
Protein
Gene SymbolKRT6B to neXtProt (NX_P04259)
DescriptionKeratin, type II cytoskeletal 6B
Chromosome12
Location12q13.13 (52840435 ~ 52845910) to Ensembl
Sequene Features : Isoforms 1, Variants 100, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.ectoderm development .structural constituent of cytoskeleton .extracellular exosome
.keratin filament
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 100 2
2014-09-19protein level
1 81 2
2014-05-27protein level
1 81 9
2014-02-25protein level
1 81 8
2013-12-09protein level
1 68 8
2013-11-01protein level
1 67 6
2013-09-12protein level
1 67 6
2013-08-17protein level
1 67 6
2013-07-15protein level
1 55 5
2013-06-11protein level
1 55 5
2013-02-12protein level
1 31 5
2012-12-20protein level
1 34 5
2012-10-30protein level
1 36 5
2012-10-07protein level
1 36 5
2012-08-24protein level
1 29 5
2012-07-28protein level
1 30 5
2012-06-08protein level
1 35 5
2012-05-07protein level
1 34 5
2012-04-10protein level
1 34 5
2012-01-13protein level
1 22 5
2011-12-20protein level
1 22 5
2011-11-11protein level
1 22 4
2011-08-23protein level
1 21 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P04259-1
2 0 26 60030.1176
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740907,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
2 EBI-740907,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
3 EBI-740907,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
4 EBI-740907,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
5 EBI-740907,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
6 EBI-740907,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
7 EBI-740907,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
8 EBI-740907,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder703
brain9
connective tissue6
esophagus1190
heart44
intestine25
larynx3238
lung17
mammary gland152
mouth755
muscle18
pancreas4
pharynx638
placenta7
prostate5
skin417
stomach20
testis2
thyroid171
uterus17
Health State
TissuesTPM*
normal19
bladder carcinoma1194
breast (mammary gland) tumor10
colorectal tumor53
esophageal tumor1159
gastrointestinal tumor16
glioma74
head and neck tumor1076
lung tumor19
pancreatic tumor9
skin tumor582
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult95
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix1.9
esophagus495.8
salivary gland1.9
skin63.5
Tissues
TissuesExpression level
bronchusMedium
cervix, uterineHigh
esophagusHigh
nasopharynxMedium
oral mucosaHigh
skin 1High
skin 2High
tonsilHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*148042, gene) Keratin 6b; KRT6BOMIM


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