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> Protein (NX_P04271)
Protein (NX_P04271)
Protein
Gene SymbolS100B to neXtProt (NX_P04271)
DescriptionProtein S100-B
Chromosome21
Location21q22.3 (48018875 ~ 48025121) to Ensembl
Sequene Features : Isoforms 1, Variants 12, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of skeletal muscle cell differentiation
.cellular response to hypoxia
.long-term synaptic potentiation
  + 14 more...
.RAGE receptor binding
.calcium-dependent protein binding
.tau protein binding
  + 5 more...
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.neuronal cell body
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 12 2
2014-09-19protein level
1 9 2
2014-05-27protein level
1 9 2
2014-02-25protein level
1 9 2
2013-12-09protein level
1 9 2
2013-11-01protein level
1 9 2
2013-09-12protein level
1 9 2
2013-08-17protein level
1 9 2
2013-07-15protein level
1 4 2
2013-06-11protein level
1 4 2
2013-02-12protein level
1 2 1
2012-12-20protein level
1 2 1
2012-10-30protein level
1 2 1
2012-10-07protein level
1 2 1
2012-08-24protein level
1 0 1
2012-07-28protein level
1 0 1
2012-06-08protein level
1 0 1
2012-05-07protein level
1 1 1
2012-04-10protein level
1 1 1
2012-01-13protein level
1 1 1
2011-12-20protein level
1 1 1
2011-11-11protein level
1 1 1
2011-08-23protein level
1 1 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P04271-1
3 0 0 10706.0208
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-458391,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-458391,EBI-352877 S100A6  
  .positive regulation of fibroblast proliferation
.axonogenesis
.signal transduction
.calcium-dependent protein binding
.S100 protein binding
.protein homodimerization activity
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.extrinsic component of cytoplasmic side of plasma membrane
  + 5 more...
3 EBI-458391,EBI-743686 S100A1  
  .positive regulation of voltage-gated calcium channel activity
.intracellular signal transduction
.substantia nigra development
  + 2 more...
.ATPase binding
.S100 protein binding
.protein homodimerization activity
  + 2 more...
.protein complex
.neuron projection
.M band
  + 3 more...
4 EBI-458391,EBI-743700 S100P  
  .endothelial cell migration
.response to organic substance
.calcium-dependent protein binding
.calcium ion binding
.magnesium ion binding
.extracellular exosome
.microvillus membrane
.cytoplasm
.nucleus
5 EBI-458391,EBI-717058 S100A4  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.epithelial to mesenchymal transition
.RAGE receptor binding
.poly(A) RNA binding
.calcium ion binding
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 2 more...
6 EBI-458391,EBI-752230 S100A2  
  .endothelial cell migration .identical protein binding
.calcium ion binding
.N/A
7 EBI-458391,EBI-701862 S100A11  
  .negative regulation of cell proliferation
.negative regulation of DNA replication
.signal transduction
.calcium-dependent protein binding
.S100 protein binding
.protein homodimerization activity
.calcium ion binding
.extracellular exosome
.cytoplasm
.nucleoplasm
  + 3 more...
8 EBI-458391,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
9 EBI-458391,EBI-1646426 AGER  
  .positive regulation of NF-kappaB transcription factor activity
.induction of positive chemotaxis
.innate immune response
  + 4 more...
.S100 protein binding
.identical protein binding
.transmembrane signaling receptor activity
.receptor activity
.integral component of plasma membrane
.plasma membrane
.extracellular region
10 EBI-458391,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
blood16
brain159
connective tissue20
ear1490
eye47
heart145
lung14
mammary gland79
nerve128
ovary29
pancreas32
pharynx24
placenta21
prostate21
skin308
uterus34
Health State
TissuesTPM*
normal44
adrenal tumor237
breast (mammary gland) tumor118
chondrosarcoma12
germ cell tumor60
glioma102
head and neck tumor7
leukemia21
non-neoplasia10
ovarian tumor39
pancreatic tumor66
skin tumor518
uterine tumor88
Developmental Stage
TissuesTPM*
adult37
fetus77
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue144.1
adrenal gland31.9
appendix12.3
bone marrow1.7
cerebral cortex293.7
colon19.1
duodenum8.3
esophagus19.4
gallbladder21
heart muscle12.1
lung4
lymph node27.5
ovary3.5
pancreas2.6
placenta1.5
prostate8.2
salivary gland17.6
skin9.7
small intestine15.9
spleen11.7
stomach11
testis1.4
thyroid gland1.1
urinary bladder21.5
Tissues
TissuesExpression level
breastHigh
cerebellumHigh
cerebral cortexHigh
endometrium 1Medium
endometrium 2Low
fallopian tubeMedium
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
lungMedium
ovaryLow
pancreasLow
parathyroid glandMedium
prostateLow
salivary glandMedium
skeletal muscleMedium
skin 1Medium
soft tissue 1Medium
soft tissue 2High
stomach 1Medium
stomach 2Medium
testisLow
thyroid glandMedium
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176990, gene) S100 calcium-binding protein, beta; S100BOMIM


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