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> Protein (NX_P04275)
Protein (NX_P04275)
Protein
Gene SymbolVWF to neXtProt (NX_P04275)
Descriptionvon Willebrand factor
Chromosome12
Location12p13.31 (6058040 ~ 6233936) to Ensembl
Sequene Features : Isoforms 2, Variants 536, PTMs 56 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein homooligomerization
.cell-substrate adhesion
.extracellular matrix organization
  + 9 more...
.chaperone binding
.protein N-terminus binding
.protein homodimerization activity
  + 6 more...
.extracellular exosome
.Weibel-Palade body
.platelet alpha granule lumen
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 536 56
2014-09-19protein level
1 439 56
2014-05-27protein level
1 437 56
2014-02-25protein level
1 431 56
2013-12-09protein level
1 347 56
2013-11-01protein level
1 322 56
2013-09-12protein level
1 322 56
2013-08-17protein level
1 322 56
2013-07-15protein level
1 262 56
2013-06-11protein level
1 262 56
2013-02-12protein level
1 188 56
2012-12-20protein level
1 185 56
2012-10-30protein level
1 203 56
2012-10-07protein level
1 203 56
2012-08-24protein level
1 174 56
2012-07-28protein level
1 174 56
2012-06-08protein level
1 180 56
2012-05-07protein level
1 179 56
2012-04-10protein level
1 178 56
2012-01-13protein level
1 227 56
2011-12-20protein level
1 227 56
2011-11-11protein level
1 227 56
2011-08-23protein level
1 228 56
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P04275-1
129 12 0 309057.0638
NX_P04275-2
4 12 0 38719.9409
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-981819,EBI-297082 GP1BA  
  .thrombin receptor signaling pathway
.fibrinolysis
.regulation of blood coagulation
  + 6 more...
.thrombin receptor activity .extracellular exosome
.anchored component of external side of plasma membrane
.membrane
  + 3 more...
2 EBI-981819,EBI-981764 ADAMTS13  
  .response to interleukin-4
.cellular protein metabolic process
.post-translational protein modification
  + 12 more...
.zinc ion binding
.metallopeptidase activity
.calcium ion binding
  + 2 more...
.cell surface
.endoplasmic reticulum lumen
.extracellular space
.proteinaceous extracellular matrix
3 EBI-981819,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue854
adrenal gland60
blood8
bone55
brain57
connective tissue100
esophagus49
eye95
heart189
intestine77
kidney52
larynx85
liver9
lung119
lymph node11
mammary gland119
mouth60
muscle65
nerve450
ovary78
pancreas23
pharynx147
placenta222
prostate52
skin9
spleen393
stomach94
testis25
thymus37
thyroid214
trachea135
umbilical cord3995
uterus94
vascular290
Health State
TissuesTPM*
normal104
adrenal tumor158
breast (mammary gland) tumor118
chondrosarcoma120
colorectal tumor62
esophageal tumor57
gastrointestinal tumor67
germ cell tumor15
glioma18
head and neck tumor52
kidney tumor72
leukemia10
liver tumor20
lung tumor38
lymphoma13
non-neoplasia124
ovarian tumor65
pancreatic tumor47
prostate cancer9
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor55
Developmental Stage
TissuesTPM*
adult126
neonate1190
fetus84
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue110.4
adrenal gland4.8
appendix18.9
cerebral cortex9.2
colon16.2
duodenum10.8
esophagus18.6
gallbladder32.1
heart muscle61.1
kidney2.7
liver1.4
lung85.4
lymph node21.8
ovary9
pancreas5
placenta46.8
prostate12.7
salivary gland10.5
skin8
small intestine6.3
spleen37.1
stomach6.8
testis15
thyroid gland29.7
urinary bladder41.4
Tissues
TissuesExpression level
bone marrowMedium
cerebral cortexHigh
colonHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#193400, phenotype) Von willebrand disease, type 1; VWD1OMIM
2(#277480, phenotype) Von willebrand disease, type 3; VWD3OMIM
3(*613160, gene) Von willebrand factor; VWFOMIM
4(#613554, phenotype) Von willebrand disease, type 2; VWD2OMIM


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