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> Protein (NX_P04626)
Protein (NX_P04626)
Protein
Gene SymbolERBB2 to neXtProt (NX_P04626)
DescriptionReceptor tyrosine-protein kinase erbB-2
Chromosome17
Location17q12 (37844167 ~ 37886679) to Ensembl
Sequene Features : Isoforms 6, Variants 190, PTMs 43 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 190 43
2014-09-19protein level
6 165 43
2014-05-27protein level
5 165 45
2014-02-25protein level
4 164 45
2013-12-09protein level
4 135 45
2013-11-01protein level
4 132 40
2013-09-12protein level
4 132 40
2013-08-17protein level
4 132 40
2013-07-15protein level
4 107 40
2013-06-11protein level
4 107 40
2013-02-12protein level
4 77 95
2012-12-20protein level
4 74 95
2012-10-30protein level
4 82 95
2012-10-07protein level
4 82 39
2012-08-24protein level
4 79 39
2012-07-28protein level
4 79 39
2012-06-08protein level
4 88 39
2012-05-07protein level
4 40 39
2012-04-10protein level
4 40 39
2012-01-13protein level
4 27 39
2011-12-20protein level
4 27 39
2011-11-11protein level
4 27 38
2011-08-23protein level
4 27 38
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P04626-1
0 47 4 137820.7736
NX_P04626-2
0 23 4 70871.5896
NX_P04626-3
0 21 4 62528.2291
NX_P04626-4
1 45 4 136411.9777
NX_P04626-5
0 45 4 134768.2274
NX_P04626-6
7 26 1 97188.7906
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-641062,EBI-81694 APBB1  
  .negative regulation of thymidylate synthase biosynthetic process
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 17 more...
.proline-rich region binding
.histone binding
.transcription factor binding
  + 2 more...
.synapse
.growth cone
.lamellipodium
  + 4 more...
2 EBI-641062,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
3 EBI-641062,EBI-641107 PIK3C2B  
  .cell chemotaxis
.phosphatidylinositol phosphorylation
.innate immune response
  + 10 more...
.phosphatidylinositol binding
.1-phosphatidylinositol-4-phosphate 3-kinase activity
.1-phosphatidylinositol-3-kinase activity
  + 2 more...
.endocytic vesicle
.phosphatidylinositol 3-kinase complex
.plasma membrane
  + 4 more...
4 EBI-641062,EBI-355867 XPO1  
  .intracellular transport of virus
.mRNA transport
.regulation of protein export from nucleus
  + 15 more...
.protein transporter activity
.nucleocytoplasmic transporter activity
.transporter activity
.RNA binding
.intracellular membrane-bounded organelle
.nuclear membrane
.ribonucleoprotein complex
  + 10 more...
5 EBI-641062,EBI-968198 SOCS1  
  .cellular response to amino acid stimulus
.JAK-STAT cascade involved in growth hormone signaling pathway
.regulation of type I interferon-mediated signaling pathway
  + 13 more...
.protein kinase binding
.kinase inhibitor activity
.insulin-like growth factor receptor binding
.protein kinase inhibitor activity
.cytoplasmic membrane-bounded vesicle
.cytosol
.cytoplasm
.nucleus
6 EBI-641062,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
7 EBI-641062,EBI-2868511 H2AFY  
  .negative regulation of cell cycle G2/M phase transition
.negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
.negative regulation of protein serine/threonine kinase activity
  + 13 more...
.transcription regulatory region DNA binding
.nucleosomal DNA binding
.chromatin DNA binding
  + 8 more...
.extracellular exosome
.nucleolus
.pericentric heterochromatin
  + 8 more...
8 EBI-641062,EBI-740418 GRAP2  
  .T cell receptor signaling pathway
.innate immune response
.Fc-epsilon receptor signaling pathway
  + 4 more...
.SH3/SH2 adaptor activity .cytosol
.endosome
.cytoplasm
  + 2 more...
9 EBI-641062,EBI-702336 BCAR3  
  .response to drug
.positive regulation of peptidyl-serine phosphorylation
.small GTPase mediated signal transduction
  + 2 more...
.guanyl-nucleotide exchange factor activity .N/A
10 EBI-641062,EBI-359472 POLR1A  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.gene expression
  + 4 more...
.zinc ion binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytoplasm
.DNA-directed RNA polymerase I complex
.nucleolus
  + 2 more...
11 EBI-641062,EBI-2823742 RECK  
  .extracellular matrix organization
.negative regulation of endopeptidase activity
.embryo implantation
.blood vessel maturation
.metalloendopeptidase inhibitor activity
.serine-type endopeptidase inhibitor activity
.endopeptidase inhibitor activity
.anchored component of membrane
.membrane
.plasma membrane
12 EBI-641062,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
13 EBI-641062,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
14 EBI-641062,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
15 EBI-641062,EBI-296047 HSP90AA1  
  .regulation of cellular response to heat
.positive regulation of cardiac muscle contraction
.chaperone-mediated protein complex assembly
  + 26 more...
.GTPase binding
.poly(A) RNA binding
.protein homodimerization activity
  + 12 more...
.endocytic vesicle lumen
.extracellular exosome
.perinuclear region of cytoplasm
  + 17 more...
16 EBI-641062,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
17 EBI-641062,EBI-1341 PTPRC  
  .positive regulation of stem cell proliferation
.positive regulation of hematopoietic stem cell migration
.regulation of cell cycle
  + 24 more...
.protein kinase binding
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.membrane raft
.membrane
  + 5 more...
18 EBI-641062,EBI-1383732 FGR  
  .cellular response to peptide hormone stimulus
.defense response to Gram-positive bacterium
.regulation of phagocytosis
  + 22 more...
.Fc-gamma receptor I complex binding
.immunoglobulin receptor binding
.protein kinase binding
  + 4 more...
.extracellular exosome
.ruffle membrane
.extrinsic component of cytoplasmic side of plasma membrane
  + 5 more...
19 EBI-641062,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
20 EBI-641062,EBI-617403 PLCG2  
  .release of sequestered calcium ion into cytosol
.B cell receptor signaling pathway
.T cell receptor signaling pathway
  + 19 more...
.signal transducer activity
.phospholipase C activity
.phosphatidylinositol phospholipase C activity
.extracellular exosome
.plasma membrane
.cytosol
21 EBI-641062,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
22 EBI-641062,EBI-1026476 RASA1  
  .regulation of RNA metabolic process
.blood vessel morphogenesis
.ephrin receptor signaling pathway
  + 14 more...
.GTPase binding
.potassium channel inhibitor activity
.receptor binding
  + 2 more...
.intrinsic component of the cytoplasmic side of the plasma membrane
.cytosol
.cytoplasm
.ruffle
23 EBI-641062,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
24 EBI-641062,EBI-1383438 JAK1  
  .regulation of type I interferon-mediated signaling pathway
.type I interferon signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
  + 12 more...
.protein phosphatase binding
.ATP binding
.growth hormone receptor binding
  + 2 more...
.extrinsic component of cytoplasmic side of plasma membrane
.endomembrane system
.focal adhesion
  + 4 more...
25 EBI-641062,EBI-1265766 PTPRB  
  .peptidyl-tyrosine dephosphorylation
.dephosphorylation
.phosphate-containing compound metabolic process
  + 2 more...
.transmembrane receptor protein tyrosine phosphatase activity .receptor complex
.integral component of plasma membrane
26 EBI-641062,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
27 EBI-641062,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
28 EBI-641062,EBI-517592 IRS1  
  .positive regulation of glucose import in response to insulin stimulus
.JAK-STAT cascade involved in growth hormone signaling pathway
.phosphatidylinositol-mediated signaling
  + 29 more...
.phosphatidylinositol 3-kinase binding
.SH2 domain binding
.insulin-like growth factor receptor binding
  + 4 more...
.intracellular membrane-bounded organelle
.ciliary basal body
.caveola
  + 5 more...
29 EBI-641062,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
30 EBI-641062,EBI-1057697 STAT1  
  .negative regulation of metanephric nephron tubule epithelial cell differentiation
.metanephric mesenchymal cell differentiation
.metanephric mesenchymal cell proliferation involved in metanephros development
  + 37 more...
.protein homodimerization activity
.identical protein binding
.enzyme binding
  + 7 more...
.dendrite
.axon
.cytosol
  + 5 more...
31 EBI-641062,EBI-751664 MATK  
  .innate immune response
.regulation of cell proliferation
.peptidyl-tyrosine autophosphorylation
  + 8 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytosol
32 EBI-641062,EBI-1102694 ABL2  
  .negative regulation of endothelial cell apoptotic process
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 41 more...
.actin filament binding
.manganese ion binding
.ATP binding
  + 6 more...
.dendritic spine
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
  + 3 more...
33 EBI-641062,EBI-78302 SYK  
  .regulation of platelet aggregation
.regulation of arachidonic acid secretion
.cellular response to molecule of fungal origin
  + 49 more...
.ATP binding
.integrin binding
.receptor signaling protein tyrosine kinase activity
  + 4 more...
.protein complex
.T cell receptor complex
.early phagosome
  + 6 more...
34 EBI-641062,EBI-910 CRKL  
  .parathyroid gland development
.thymus development
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.poly(A) RNA binding
.SH3/SH2 adaptor activity
.signal transducer activity
.extracellular exosome
.cytosol
.endosome
35 EBI-641062,EBI-297509 IQGAP1  
  .neuron projection extension
.glomerular visceral epithelial cell development
.positive regulation of protein serine/threonine kinase activity
  + 16 more...
.protein serine/threonine kinase activator activity
.protein phosphatase binding
.protein kinase binding
  + 5 more...
.extracellular exosome
.neuron projection
.cytoplasmic ribonucleoprotein granule
  + 15 more...
36 EBI-641062,EBI-973138 RANBP2  
  .regulation of cellular response to heat
.regulation of gluconeogenesis involved in cellular glucose homeostasis
.transmembrane transport
  + 21 more...
.ligase activity
.Ran GTPase binding
.zinc ion binding
  + 2 more...
.nuclear pore nuclear basket
.nuclear inclusion body
.nuclear membrane
  + 4 more...
37 EBI-641062,EBI-297549 VAV2  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.ephrin receptor signaling pathway
  + 17 more...
.metal ion binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.plasma membrane
.cytosol
38 EBI-641062,EBI-353944 ACTB  
  .platelet aggregation
.membrane organization
.'de novo' posttranslational protein folding
  + 17 more...
.nitric-oxide synthase binding
.identical protein binding
.Tat protein binding
  + 3 more...
.blood microparticle
.MLL5-L complex
.extracellular exosome
  + 16 more...
39 EBI-641062,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
40 EBI-641062,EBI-7256023 SHC2  
  .neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
.insulin receptor signaling pathway
  + 3 more...
.receptor tyrosine kinase binding
.protein kinase binding
.plasma membrane
.cytosol
41 EBI-641062,EBI-538287 EFNB1  
  .ephrin receptor signaling pathway
.positive regulation of T cell proliferation
.embryonic pattern specification
  + 4 more...
.ephrin receptor binding .extracellular exosome
.synapse
.membrane raft
  + 4 more...
42 EBI-641062,EBI-2460927 NRG1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of cardiac muscle cell differentiation
.positive regulation of protein targeting to mitochondrion
  + 46 more...
.ErbB-3 class receptor binding
.receptor tyrosine kinase binding
.transmembrane receptor protein tyrosine kinase activator activity
  + 5 more...
.neuromuscular junction
.axon
.apical plasma membrane
  + 6 more...
43 EBI-641062,EBI-2266035 PTPN12  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.SH3 domain binding
.non-membrane spanning protein tyrosine phosphatase activity
.cell projection
.cell junction
.plasma membrane
  + 3 more...
44 EBI-641062,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
45 EBI-641062,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
46 EBI-641062,EBI-968552 ITK  
  .T cell receptor signaling pathway
.innate immune response
.regulation of cell proliferation
  + 13 more...
.metal ion binding
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cell-cell junction
.cytosol
47 EBI-641062,EBI-2264500 PTPRJ  
  .negative regulation of receptor activity
.contact inhibition
.negative regulation of protein kinase B signaling
  + 21 more...
.delta-catenin binding
.mitogen-activated protein kinase binding
.gamma-catenin binding
  + 5 more...
.extracellular exosome
.ruffle membrane
.cell junction
  + 6 more...
48 EBI-641062,EBI-722813 MAPK8IP2  
  .regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
.regulation of N-methyl-D-aspartate selective glutamate receptor activity
.regulation of excitatory postsynaptic membrane potential
  + 13 more...
.protein kinase activator activity
.protein kinase binding
.kinesin binding
  + 3 more...
.neuronal postsynaptic density
.protein complex
.neuronal cell body
.cytoplasm
49 EBI-641062,EBI-1383632 PTK6  
  .cellular response to retinoic acid
.negative regulation of protein tyrosine kinase activity
.intestinal epithelial cell differentiation
  + 12 more...
.identical protein binding
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleoplasm
  + 2 more...
50 EBI-641062,EBI-970191 GRB7  
  .leukocyte migration
.stress granule assembly
.positive regulation of cell migration
  + 4 more...
.identical protein binding
.phosphatidylinositol binding
.protein kinase binding
  + 2 more...
.cell projection
.cytoplasmic stress granule
.focal adhesion
  + 2 more...
51 EBI-641062,EBI-286758 KPNB1  
  .intracellular transport of virus
.small molecule metabolic process
.cytokine-mediated signaling pathway
  + 10 more...
.poly(A) RNA binding
.protein domain specific binding
.enzyme binding
  + 3 more...
.endoplasmic reticulum tubular network
.extracellular exosome
.nuclear membrane
  + 6 more...
52 EBI-641062,EBI-298113 EEA1  
  .early endosome to late endosome transport
.synaptic vesicle to endosome fusion
.vesicle fusion
.endocytosis
.protein homodimerization activity
.GTP-dependent protein binding
.zinc ion binding
  + 2 more...
.extracellular exosome
.recycling endosome
.axonal spine
  + 8 more...
53 EBI-641062,EBI-474052 PTPRK  
  .focal adhesion assembly
.negative regulation of transcription, DNA-templated
.negative regulation of cell cycle
  + 12 more...
.gamma-catenin binding
.protein kinase binding
.beta-catenin binding
  + 2 more...
.neuronal cell body
.leading edge membrane
.dendrite
  + 7 more...
54 EBI-641062,EBI-80371 ERBB4  
  .positive regulation of STAT protein import into nucleus
.positive regulation of ERK1 and ERK2 cascade
.cardiac muscle tissue regeneration
  + 33 more...
.transcription regulatory region DNA binding
.protein homodimerization activity
.ATP binding
  + 4 more...
.receptor complex
.basolateral plasma membrane
.integral component of membrane
  + 7 more...
55 EBI-641062,EBI-295634 CDC37  
  .regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
56 EBI-641062,EBI-723739 PTPRO  
  .negative regulation of retinal ganglion cell axon guidance
.negative regulation of canonical Wnt signaling pathway
.glomerular visceral epithelial cell differentiation
  + 12 more...
.protein homodimerization activity
.Wnt-protein binding
.phosphatase activity
  + 2 more...
.extracellular exosome
.dendritic spine
.neuron projection
  + 8 more...
57 EBI-641062,EBI-949753 TENC1  
  .multicellular organismal homeostasis
.intracellular signal transduction
.multicellular organism growth
  + 5 more...
.metal ion binding
.kinase binding
.phosphoprotein phosphatase activity
.focal adhesion
.plasma membrane
58 EBI-641062,EBI-1220488 TNS3  
  .lung alveolus development
.cell migration
.positive regulation of cell proliferation
.N/A .focal adhesion
.cytoplasm
59 EBI-641062,EBI-2515547 SUPT6H  
  .negative regulation of histone H3-K27 methylation
.regulation of muscle cell differentiation
.mRNA transport
  + 10 more...
.poly(A) RNA binding
.histone binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
60 EBI-641062,EBI-7878194 CLNK  
  .intracellular signal transduction
.positive regulation of signal transduction
.transmembrane receptor protein tyrosine kinase signaling pathway
.immune response
.SH3/SH2 adaptor activity .intracellular
61 EBI-641062,EBI-6918542 DOK4  
  .nervous system development
.transmembrane receptor protein tyrosine kinase signaling pathway
.MAPK cascade
.receptor signaling protein activity .N/A
62 EBI-641062,EBI-79084 SHC3  
  .neurotrophin TRK receptor signaling pathway
.synaptic transmission, glutamatergic
.insulin receptor signaling pathway
  + 5 more...
.receptor tyrosine kinase binding
.protein kinase binding
.signal transducer activity
.plasma membrane
.cytosol
63 EBI-641062,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
64 EBI-641062,EBI-1048612 ANKS1A  
  .ephrin receptor signaling pathway
.neuron remodeling
.substrate-dependent cell migration
.N/A .neuron projection
.cytoplasm
.nucleoplasm
65 EBI-641062,EBI-1384360 DOK1  
  .insulin receptor signaling pathway
.Ras protein signal transduction
.transmembrane receptor protein tyrosine kinase signaling pathway
  + 2 more...
.receptor signaling protein activity .perinuclear region of cytoplasm
.cytosol
.cytoplasm
.nucleus
66 EBI-641062,EBI-1222854 SLA2  
  .negative regulation of B cell activation
.antigen receptor-mediated signaling pathway
.negative regulation of calcium-mediated signaling
  + 6 more...
.protein N-terminus binding
.SH3/SH2 adaptor activity
.cytoplasmic membrane-bounded vesicle
.endosome membrane
.plasma membrane
  + 2 more...
67 EBI-641062,EBI-490630 SH2D2A  
  .vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .cytosol
.cytoplasm
68 EBI-641062,EBI-617866 CISH  
  .JAK-STAT cascade involved in growth hormone signaling pathway
.negative regulation of insulin receptor signaling pathway
.negative regulation of JAK-STAT cascade
  + 6 more...
.protein kinase inhibitor activity .plasma membrane
.cytosol
.cytoplasm
69 EBI-641062,EBI-2941912 ERRFI1  
  .lung epithelium development
.lung vasculature development
.lung alveolus development
  + 6 more...
.protein kinase binding
.GTPase activator activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
70 EBI-641062,EBI-78404 MAPK8IP1  
  .negative regulation of intrinsic apoptotic signaling pathway
.regulation of JNK cascade
.negative regulation of JUN kinase activity
  + 3 more...
.kinesin binding
.MAP-kinase scaffold activity
.protein kinase inhibitor activity
.perinuclear region of cytoplasm
.synapse
.dentate gyrus mossy fiber
  + 8 more...
71 EBI-641062,EBI-1104564 MEMO1  
  .regulation of microtubule-based process .N/A .cytosol
.nucleus
72 EBI-641062,EBI-2462036 TLN1  
  .platelet aggregation
.cellular protein metabolic process
.IRE1-mediated unfolded protein response
  + 12 more...
.LIM domain binding
.vinculin binding
.structural constituent of cytoskeleton
.integrin binding
.extracellular exosome
.ruffle membrane
.cell surface
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites125
bladder133
blood8
bone27
bone marrow20
brain25
cervix20
connective tissue26
embryonic tissue173
eye114
heart33
intestine340
kidney33
larynx340
liver34
lung62
lymph node33
mammary gland390
mouth196
muscle150
nerve193
ovary118
pancreas32
pharynx24
placenta134
prostate58
salivary gland98
skin18
spleen37
stomach83
testis50
thymus12
thyroid128
trachea115
uterus43
Health State
TissuesTPM*
normal59
bladder carcinoma170
breast (mammary gland) tumor633
cervical tumor28
chondrosarcoma72
colorectal tumor577
gastrointestinal tumor126
germ cell tumor60
glioma27
head and neck tumor186
kidney tumor58
leukemia21
liver tumor62
lung tumor19
non-neoplasia31
ovarian tumor118
pancreatic tumor66
prostate cancer48
soft tissue/muscle tissue tumor39
uterine tumor77
Developmental Stage
TissuesTPM*
adult140
embryoid body214
blastocyst276
fetus41
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.7
adrenal gland5.2
appendix15
bone marrow1.3
cerebral cortex7.1
colon52.7
duodenum59.8
esophagus68.8
gallbladder32.2
heart muscle39.1
kidney68.6
liver21
lung36.2
lymph node5.5
ovary24.8
pancreas15.3
placenta35
prostate45.4
salivary gland48.8
skin80.6
small intestine63.1
spleen6.5
stomach47.4
testis11.5
thyroid gland43
urinary bladder49.4
Tissues
TissuesExpression level
appendixLow
breastMedium
bronchusLow
cervix, uterineLow
colonLow
duodenumLow
epididymisLow
kidneyLow
nasopharynxLow
placentaMedium
prostateLow
rectumLow
small intestineLow
tonsilLow
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#137215, phenotype) Gastric cancer, hereditary diffuse; HDGCOMIM
2(#137800, phenotype) Glioma susceptibility 1; GLM1OMIM
3(*164870, gene) V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; ERBB2OMIM
4(#167000, phenotype) Ovarian cancerOMIM
5(#211980, phenotype) Lung cancerOMIM
6(#613659, phenotype) Gastric cancerOMIM
7breast;ovarian;other tumour types;non small cell lung cancer;gastricCGP


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