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> Protein (NX_P04632)
Protein (NX_P04632)
Protein
Gene SymbolCAPNS1 to neXtProt (NX_P04632)
DescriptionCalpain small subunit 1
Chromosome19
Location19q13.12 (36630477 ~ 36641255) to Ensembl
Sequene Features : Isoforms 1, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.extracellular matrix organization
.extracellular matrix disassembly
.positive regulation of cell proliferation
.proteolysis
.calcium ion binding
.calcium-dependent cysteine-type endopeptidase activity
.extracellular exosome
.membrane
.plasma membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 25 5
2014-09-19protein level
1 20 5
2014-05-27protein level
1 20 5
2014-02-25protein level
1 20 5
2013-12-09protein level
1 13 5
2013-11-01protein level
1 13 4
2013-09-12protein level
1 13 4
2013-08-17protein level
1 13 4
2013-07-15protein level
1 6 3
2013-06-11protein level
1 6 3
2013-02-12protein level
1 2 2
2012-12-20protein level
1 3 2
2012-10-30protein level
1 5 2
2012-10-07protein level
1 5 2
2012-08-24protein level
1 5 2
2012-07-28protein level
1 5 2
2012-06-08protein level
1 10 2
2012-05-07protein level
1 9 2
2012-04-10protein level
1 9 2
2012-01-13protein level
1 12 2
2011-12-20protein level
1 12 2
2011-11-11protein level
1 12 2
2011-08-23protein level
1 12 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P04632-1
10 0 0 28297.6533
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-711828,EBI-1028956 CAPN2  
  .cellular response to amino acid stimulus
.proteolysis involved in cellular protein catabolic process
.regulation of cytoskeleton organization
  + 5 more...
.cysteine-type peptidase activity
.cytoskeletal protein binding
.calcium ion binding
.calcium-dependent cysteine-type endopeptidase activity
.perinuclear endoplasmic reticulum
.extracellular exosome
.membrane raft
  + 11 more...
2 EBI-711828,EBI-1026476 RASA1  
  .regulation of RNA metabolic process
.blood vessel morphogenesis
.ephrin receptor signaling pathway
  + 14 more...
.GTPase binding
.potassium channel inhibitor activity
.receptor binding
  + 2 more...
.intrinsic component of the cytoplasmic side of the plasma membrane
.cytosol
.cytoplasm
.ruffle
3 EBI-711828,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites276
bladder200
blood89
bone418
bone marrow164
brain104
cervix268
connective tissue201
embryonic tissue267
esophagus99
eye292
heart201
intestine331
kidney222
larynx980
liver155
lung301
lymph225
lymph node77
mammary gland495
mouth453
muscle159
nerve514
ovary433
pancreas384
parathyroid242
pharynx98
pituitary gland484
placenta130
prostate406
salivary gland641
skin336
spleen112
stomach386
testis107
thymus50
thyroid386
tonsil235
umbilical cord290
uterus383
vascular116
Health State
TissuesTPM*
normal155
adrenal tumor237
bladder carcinoma56
breast (mammary gland) tumor397
cervical tumor231
chondrosarcoma531
colorectal tumor391
esophageal tumor115
gastrointestinal tumor354
germ cell tumor68
glioma354
head and neck tumor575
kidney tumor464
leukemia105
liver tumor218
lung tumor379
lymphoma249
non-neoplasia165
ovarian tumor472
pancreatic tumor619
primitive neuroectodermal tumor of the CNS173
prostate cancer452
retinoblastoma193
skin tumor438
soft tissue/muscle tissue tumor287
uterine tumor532
Developmental Stage
TissuesTPM*
adult314
embryoid body300
blastocyst195
neonate128
fetus66
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue240
adrenal gland180.9
appendix174.8
bone marrow136.7
cerebral cortex141.3
colon250.9
duodenum224.5
esophagus383
gallbladder180
heart muscle317
kidney200.5
liver88.7
lung254.6
lymph node144.6
ovary174
pancreas78
placenta126.4
prostate203.2
salivary gland126.8
skin69.4
small intestine230.5
spleen174.9
stomach188.3
testis147.9
thyroid gland208.1
urinary bladder239.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonMedium
duodenumLow
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleLow
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumMedium
salivary glandHigh
seminal vesicleHigh
skin 1Medium
skin 2Low
small intestineLow
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*114170, gene) Calpain, small subunit 1; CAPNS1OMIM


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