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> Protein (NX_P04637)
Protein (NX_P04637)
Protein
Gene SymbolTP53 to neXtProt (NX_P04637)
DescriptionCellular tumor antigen p53
Chromosome17
Location17p13.1 (7565097 ~ 7590856) to Ensembl
Sequene Features : Isoforms 9, Variants 1723, PTMs 34 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
9 1723 34
2014-09-19protein level
9 1706 34
2014-05-27protein level
9 1705 34
2014-02-25protein level
9 1650 33
2013-12-09protein level
9 1648 33
2013-11-01protein level
9 1648 27
2013-09-12protein level
9 1648 27
2013-08-17protein level
9 1648 27
2013-07-15protein level
9 1648 27
2013-06-11protein level
9 1648 27
2013-02-12protein level
9 1648 159
2012-12-20protein level
9 1648 156
2012-10-30protein level
9 1648 156
2012-10-07protein level
9 1648 29
2012-08-24protein level
9 1363 29
2012-07-28protein level
9 1363 29
2012-06-08protein level
9 1394 29
2012-05-07protein level
9 1394 29
2012-04-10protein level
9 1394 29
2012-01-13protein level
9 1397 29
2011-12-20protein level
9 1391 25
2011-11-11protein level
9 1391 25
2011-08-23protein level
9 1387 24
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P04637-1
0 15 0 43625.255
NX_P04637-2
0 14 0 37801.1794
NX_P04637-3
0 15 0 38475.6117
NX_P04637-4
0 14 0 39295.1676
NX_P04637-5
0 13 0 33471.092
NX_P04637-6
0 14 0 34145.5243
NX_P04637-7
0 9 0 29534.526
NX_P04637-8
0 8 0 23710.4504
NX_P04637-9
0 9 0 24384.8827
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-366083,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
2 EBI-366083,EBI-398437 MDM4  
  .cellular response to hypoxia
.negative regulation of cell cycle arrest
.protein stabilization
  + 9 more...
.enzyme binding
.zinc ion binding
.nucleoplasm
.nucleus
3 EBI-366083,EBI-710484 AXIN1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.Wnt signaling pathway involved in somitogenesis
  + 45 more...
.I-SMAD binding
.armadillo repeat domain binding
.SMAD binding
  + 9 more...
.cell periphery
.perinuclear region of cytoplasm
.cytoplasmic vesicle
  + 10 more...
4 EBI-366083,EBI-1644164 FOXO3  
  .regulation of reactive oxygen species metabolic process
.regulation of neural precursor cell proliferation
.extrinsic apoptotic signaling pathway in absence of ligand
  + 24 more...
.sequence-specific DNA binding
.chromatin DNA binding
.protein kinase binding
  + 5 more...
.membrane
.cytosol
.cytoplasm
  + 2 more...
5 EBI-366083,EBI-2371631 NRD1  
  .regulation of endopeptidase activity
.positive regulation of membrane protein ectodomain proteolysis
.cell migration
  + 3 more...
.epidermal growth factor binding
.metal ion binding
.metalloendopeptidase activity
.cell surface
.cytosol
6 EBI-366083,EBI-1046789 NUAK1  
  .regulation of cellular senescence
.cellular response to glucose starvation
.regulation of cell proliferation
  + 6 more...
.metal ion binding
.ATP binding
.protein serine/threonine kinase activity
.p53 binding
.AMP-activated protein kinase complex
.microtubule cytoskeleton
.cytoplasm
  + 2 more...
7 EBI-366083,EBI-629434 PIAS1  
  .protein-DNA complex assembly
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 14 more...
.SUMO ligase activity
.androgen receptor binding
.enzyme binding
  + 5 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
8 EBI-366083,EBI-348555 PIAS2  
  .negative regulation of androgen receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 7 more...
.SUMO ligase activity
.androgen receptor binding
.ligase activity
  + 4 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
9 EBI-366083,EBI-821405 MPDZ  
  .myelination
.viral process
.cell adhesion
.protein C-terminus binding .postsynaptic membrane
.Schmidt-Lanterman incisure
.cytoplasmic vesicle
  + 6 more...
10 EBI-366083,EBI-711158 ARIH2  
  .positive regulation of protein targeting to mitochondrion
.hematopoietic stem cell proliferation
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.nucleic acid binding
.cytoplasm
.nucleus
11 EBI-366083,EBI-1045459 SNAI1  
  .regulation of tight junction assembly
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.Notch signaling involved in heart development
  + 16 more...
.metal ion binding
.kinase binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleus
12 EBI-366083,EBI-458391 S100B  
  .negative regulation of skeletal muscle cell differentiation
.cellular response to hypoxia
.long-term synaptic potentiation
  + 14 more...
.RAGE receptor binding
.calcium-dependent protein binding
.tau protein binding
  + 5 more...
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.neuronal cell body
  + 5 more...
13 EBI-366083,EBI-8045030 MT1A  
  .cellular response to zinc ion
.cellular response to cadmium ion
.negative regulation of growth
.zinc ion binding .perinuclear region of cytoplasm
.cytoplasm
.nucleus
14 EBI-366083,EBI-352682 HSPB1  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.platelet aggregation
  + 17 more...
.poly(A) RNA binding
.ubiquitin binding
.identical protein binding
  + 3 more...
.extracellular exosome
.Z disc
.focal adhesion
  + 8 more...
15 EBI-366083,EBI-78579 NPM1  
  .regulation of eIF2 alpha phosphorylation by dsRNA
.regulation of endoribonuclease activity
.protein oligomerization
  + 20 more...
.unfolded protein binding
.NF-kappaB binding
.protein heterodimerization activity
  + 10 more...
.spindle pole centrosome
.ribonucleoprotein complex
.membrane
  + 7 more...
16 EBI-366083,EBI-355676 PARP1  
  .positive regulation of transcription regulatory region DNA binding
.cellular response to superoxide
.protein poly-ADP-ribosylation
  + 22 more...
.NAD binding
.protein N-terminus binding
.poly(A) RNA binding
  + 7 more...
.membrane
.nucleolus
.transcription factor complex
  + 3 more...
17 EBI-366083,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
18 EBI-366083,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
19 EBI-366083,EBI-712838 BCR  
  .regulation of cell cycle
.regulation of small GTPase mediated signal transduction
.neuromuscular process controlling balance
  + 15 more...
.kinase activity
.ATP binding
.GTPase activator activity
  + 3 more...
.extracellular exosome
.postsynaptic membrane
.protein complex
  + 4 more...
20 EBI-366083,EBI-286357 VDR  
  .vitamin D receptor signaling pathway
.mammary gland branching involved in pregnancy
.regulation of calcidiol 1-monooxygenase activity
  + 20 more...
.lithocholic acid binding
.calcitriol binding
.retinoid X receptor binding
  + 6 more...
.RNA polymerase II transcription factor complex
.receptor complex
.nucleoplasm
.nucleus
21 EBI-366083,EBI-353208 XRCC6  
  .establishment of integrated proviral latency
.cellular response to X-ray
.cellular hyperosmotic salinity response
  + 16 more...
.5'-deoxyribose-5-phosphate lyase activity
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 7 more...
.nonhomologous end joining complex
.Ku70:Ku80 complex
.membrane
  + 6 more...
22 EBI-366083,EBI-1783169 TPT1  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of apoptotic process
.regulation of apoptotic process
  + 3 more...
.poly(A) RNA binding
.calcium ion binding
.extracellular exosome
.multivesicular body
.cytoplasm
  + 2 more...
23 EBI-366083,EBI-969696 CEBPB  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.liver regeneration
.hepatocyte proliferation
  + 27 more...
.protein heterodimerization activity
.protein homodimerization activity
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  + 6 more...
.CHOP-C/EBP complex
.nuclear matrix
.cytoplasm
  + 4 more...
24 EBI-366083,EBI-351962 DDX5  
  .regulation of skeletal muscle cell differentiation
.intrinsic apoptotic signaling pathway by p53 class mediator
.regulation of androgen receptor signaling pathway
  + 13 more...
.androgen receptor binding
.poly(A) RNA binding
.pre-mRNA binding
  + 5 more...
.catalytic step 2 spliceosome
.extracellular exosome
.ribonucleoprotein complex
  + 5 more...
25 EBI-366083,EBI-346967 NCL  
  .positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
.angiogenesis
.poly(A) RNA binding
.identical protein binding
.telomeric DNA binding
  + 3 more...
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
.ribonucleoprotein complex
  + 5 more...
26 EBI-366083,EBI-355371 TBP  
  .positive regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
  + 12 more...
.repressing transcription factor binding
.transcription regulatory region DNA binding
.enzyme binding
  + 2 more...
.cytoplasm
.nuclear euchromatin
.transcription factor TFIIA complex
  + 4 more...
27 EBI-366083,EBI-721550 NR4A1  
  .phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 13 more...
.sequence-specific DNA binding
.zinc ion binding
.ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 2 more...
.nuclear membrane
.cytoplasm
.nucleoplasm
.nucleus
28 EBI-366083,EBI-743686 S100A1  
  .positive regulation of voltage-gated calcium channel activity
.intracellular signal transduction
.substantia nigra development
  + 2 more...
.ATPase binding
.S100 protein binding
.protein homodimerization activity
  + 2 more...
.protein complex
.neuron projection
.M band
  + 3 more...
29 EBI-366083,EBI-351193 RPS3  
  .positive regulation of apoptotic signaling pathway
.positive regulation of DNA N-glycosylase activity
.cell division
  + 20 more...
.iron-sulfur cluster binding
.NF-kappaB binding
.protein kinase A binding
  + 8 more...
.extracellular exosome
.ruffle membrane
.ribonucleoprotein complex
  + 9 more...
30 EBI-366083,EBI-389739 NFYA  
  .positive regulation of stem cell proliferation
.regulation of stem cell maintenance
.rhythmic process
  + 5 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.core promoter sequence-specific DNA binding
.protein-DNA complex
.CCAAT-binding factor complex
.nucleoplasm
.nucleus
31 EBI-366083,EBI-389728 NFYB  
  .positive regulation of transcription, DNA-templated
.small molecule metabolic process
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.repressing transcription factor binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.protein-DNA complex
.CCAAT-binding factor complex
.nucleoplasm
.nucleus
32 EBI-366083,EBI-717058 S100A4  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.epithelial to mesenchymal transition
.RAGE receptor binding
.poly(A) RNA binding
.calcium ion binding
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 2 more...
33 EBI-366083,EBI-752230 S100A2  
  .endothelial cell migration .identical protein binding
.calcium ion binding
.N/A
34 EBI-366083,EBI-295890 PML  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of double-strand break repair
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 57 more...
.cobalt ion binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.extrinsic component of endoplasmic reticulum membrane
.nuclear membrane
.early endosome membrane
  + 7 more...
35 EBI-366083,EBI-302388 PPP2R1A  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.peptidyl-serine dephosphorylation
.regulation of cell differentiation
  + 24 more...
.protein heterodimerization activity
.protein phosphatase type 2A regulator activity
.protein serine/threonine phosphatase activity
.antigen binding
.extracellular exosome
.membrane
.microtubule cytoskeleton
  + 5 more...
36 EBI-366083,EBI-5544229 PPIF  
  .negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of oxidative phosphorylation uncoupler activity
.regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
  + 16 more...
.cyclosporin A binding
.peptidyl-prolyl cis-trans isomerase activity
.membrane
.mitochondrial matrix
.mitochondrial inner membrane
37 EBI-366083,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
38 EBI-366083,EBI-715539 GTF2H1  
  .positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of gene expression, epigenetic
  + 17 more...
.N/A .holo TFIIH complex
.nucleoplasm
.core TFIIH complex
39 EBI-366083,EBI-354912 HSPA1L  
  .positive regulation of protein targeting to mitochondrion
.regulation of cellular response to heat
.protein refolding
  + 3 more...
.unfolded protein binding
.ATP binding
.blood microparticle
.cell body
.cytosol
  + 3 more...
40 EBI-366083,EBI-356289 PPP1CC  
  .cell division
.small molecule metabolic process
.entrainment of circadian clock by photoperiod
  + 10 more...
.protein N-terminus binding
.metal ion binding
.poly(A) RNA binding
  + 4 more...
.PTW/PP1 phosphatase complex
.MLL5-L complex
.protein complex
  + 11 more...
41 EBI-366083,EBI-354932 HSPA9  
  .cellular protein metabolic process
.negative regulation of apoptotic process
.protein targeting to mitochondrion
  + 2 more...
.unfolded protein binding
.poly(A) RNA binding
.ubiquitin protein ligase binding
.ATP binding
.extracellular exosome
.mitochondrial nucleoid
.focal adhesion
  + 3 more...
42 EBI-366083,EBI-375077 CDKN1A  
  .positive regulation of reactive oxygen species metabolic process
.regulation of DNA biosynthetic process
.negative regulation of G1/S transition of mitotic cell cycle
  + 44 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin-dependent protein kinase activating kinase activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.PCNA-p21 complex
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 4 more...
43 EBI-366083,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
44 EBI-366083,EBI-5650739 MAGEA2B  
  .negative regulation of protein acetylation
.cellular senescence
.signal transduction by p53 class mediator
  + 5 more...
.repressing transcription factor binding
.histone deacetylase binding
.ubiquitin protein ligase binding
.PML body
.nucleus
45 EBI-366083,EBI-764611 MAP1B  
  .establishment of monopolar cell polarity
.axon extension
.mitochondrion transport along microtubule
  + 5 more...
.structural molecule activity .dendritic spine
.cell junction
.postsynaptic density
  + 5 more...
46 EBI-366083,EBI-373586 GSK3B  
  .positive regulation of stem cell differentiation
.negative regulation of glycogen (starch) synthase activity
.negative regulation of type B pancreatic cell development
  + 61 more...
.NF-kappaB binding
.tau-protein kinase activity
.protein kinase A catalytic subunit binding
  + 8 more...
.perinuclear region of cytoplasm
.membrane raft
.dendritic shaft
  + 11 more...
47 EBI-366083,EBI-476768 PLK1  
  .regulation of mitotic spindle assembly
.protein localization to chromatin
.regulation of cell cycle
  + 36 more...
.protein kinase binding
.kinase activity
.anaphase-promoting complex binding
  + 4 more...
.spindle midzone
.midbody
.microtubule cytoskeleton
  + 10 more...
48 EBI-366083,EBI-286709 CSE1L  
  .cell proliferation
.apoptotic process
.protein export from nucleus
.importin-alpha export receptor activity .extracellular exosome
.membrane
.cytoplasm
  + 2 more...
49 EBI-366083,EBI-355546 PSME3  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.MDM2/MDM4 family protein binding
.endopeptidase activator activity
.identical protein binding
.p53 binding
.membrane
.proteasome activator complex
.cytosol
  + 4 more...
50 EBI-366083,EBI-304185 HNRNPK  
  .regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
.positive regulation of receptor-mediated endocytosis
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
  + 2 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cell projection
  + 7 more...
51 EBI-366083,EBI-359832 YWHAG  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 14 more...
.poly(A) RNA binding
.protein kinase C inhibitor activity
.insulin-like growth factor receptor binding
.protein kinase C binding
.extracellular exosome
.cytoplasmic vesicle membrane
.membrane
  + 2 more...
52 EBI-366083,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
53 EBI-366083,EBI-347804 CSNK2A1  
  .mitotic spindle checkpoint
.chaperone-mediated protein folding
.rhythmic process
  + 12 more...
.Hsp90 protein binding
.protein N-terminus binding
.ATP binding
.protein serine/threonine kinase activity
.NuRD complex
.Sin3 complex
.plasma membrane
  + 2 more...
54 EBI-366083,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
55 EBI-366083,EBI-954357 UBE3A  
  .regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein K48-linked ubiquitination
.prostate gland growth
  + 13 more...
.ubiquitin protein ligase activity
.metal ion binding
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleus
.proteasome complex
56 EBI-366083,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
57 EBI-366083,EBI-704279 PRKCD  
  .positive regulation of apoptotic signaling pathway
.positive regulation of response to DNA damage stimulus
.positive regulation of sphingomyelin catabolic process
  + 46 more...
.metal ion binding
.insulin receptor substrate binding
.enzyme binding
  + 6 more...
.extracellular exosome
.perinuclear region of cytoplasm
.nuclear matrix
  + 8 more...
58 EBI-366083,EBI-297202 RAD51  
  .cellular response to camptothecin
.cellular response to ionizing radiation
.protein homooligomerization
  + 12 more...
.DNA polymerase binding
.single-stranded DNA-dependent ATPase activity
.identical protein binding
  + 5 more...
.perinuclear region of cytoplasm
.PML body
.microtubule organizing center
  + 10 more...
59 EBI-366083,EBI-287195 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
60 EBI-366083,EBI-447295 EP300  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.regulation of tubulin deacetylation
  + 40 more...
.pre-mRNA intronic binding
.androgen receptor binding
.nuclear hormone receptor binding
  + 17 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
  + 2 more...
61 EBI-366083,EBI-465059 SREBF2  
  .regulation of cholesterol homeostasis
.negative regulation of cholesterol efflux
.regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
  + 9 more...
.E-box binding
.protein C-terminus binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.SREBP-SCAP-Insig complex
.ER to Golgi transport vesicle membrane
.cytosol
  + 7 more...
62 EBI-366083,EBI-396540 TP53BP1  
  .positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 5 more...
.telomeric DNA binding
.methylated histone binding
.damaged DNA binding
  + 3 more...
.cytoplasm
.replication fork
.nucleoplasm
  + 2 more...
63 EBI-366083,EBI-1266156 PPP2R5C  
  .proteasome-mediated ubiquitin-dependent protein catabolic process
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.regulation of protein phosphatase type 2A activity
  + 3 more...
.protein phosphatase type 2A regulator activity .nucleus
.chromosome, centromeric region
.protein phosphatase type 2A complex
64 EBI-366083,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
65 EBI-366083,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
66 EBI-366083,EBI-77642 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
67 EBI-366083,EBI-368417 WRN  
  .nucleic acid phosphodiester bond hydrolysis
.cellular response to gamma radiation
.positive regulation of hydrolase activity
  + 23 more...
.G-quadruplex DNA binding
.ATP-dependent 3'-5' DNA helicase activity
.3'-5' DNA helicase activity
  + 15 more...
.centrosome
.nucleolus
.nucleoplasm
68 EBI-366083,EBI-308606 CUL7  
  .positive regulation of dendrite morphogenesis
.cellular protein metabolic process
.IRE1-mediated unfolded protein response
  + 12 more...
.N/A .3M complex
.perinuclear region of cytoplasm
.Cul7-RING ubiquitin ligase complex
  + 7 more...
69 EBI-366083,EBI-348298 SAFB  
  .positive regulation of transcription from RNA polymerase II promoter
.hormone metabolic process
.growth
  + 3 more...
.poly(A) RNA binding
.double-stranded DNA binding
.chromatin binding
  + 2 more...
.nucleoplasm
.nucleus
70 EBI-366083,EBI-3910729 NR0B2  
  .negative regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of insulin secretion
.organ regeneration
  + 7 more...
.protein homodimerization activity
.protein domain specific binding
.transcription corepressor activity
  + 3 more...
.protein complex
.cytoplasm
.nucleoplasm
.nucleus
71 EBI-366083,EBI-1797287 TWIST1  
  .positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
.cell proliferation involved in heart valve development
.negative regulation of double-strand break repair
  + 51 more...
.E-box binding
.bHLH transcription factor binding
.transcription factor binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
72 EBI-366083,EBI-298304 MAPK11  
  .stress-activated MAPK cascade
.positive regulation of muscle cell differentiation
.regulation of sequence-specific DNA binding transcription factor activity
  + 25 more...
.ATP binding
.MAP kinase activity
.protein serine/threonine kinase activity
.cytosol
.nucleoplasm
73 EBI-366083,EBI-1040141 SMAD2  
  .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
74 EBI-366083,EBI-711505 LAMA4  
  .regulation of embryonic development
.regulation of cell migration
.extracellular matrix organization
  + 2 more...
.extracellular matrix structural constituent .extracellular exosome
.laminin-1 complex
.basal lamina
  + 2 more...
75 EBI-366083,EBI-6273540 IFI16  
  .negative regulation of cysteine-type endopeptidase activity
.activation of cysteine-type endopeptidase activity
.intrinsic apoptotic signaling pathway by p53 class mediator
  + 23 more...
.poly(A) RNA binding
.identical protein binding
.transcription factor binding
  + 4 more...
.nuclear speck
.membrane
.cytosol
  + 4 more...
76 EBI-366083,EBI-625934 HUWE1  
  .positive regulation of protein targeting to mitochondrion
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.cell differentiation
  + 4 more...
.poly(A) RNA binding
.ligase activity
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.membrane
.cytoplasm
  + 2 more...
77 EBI-366083,EBI-947849 SYVN1  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.cellular protein metabolic process
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 6 more...
.ubiquitin protein ligase activity
.acid-amino acid ligase activity
.zinc ion binding
.integral component of membrane
.membrane
.endoplasmic reticulum membrane
  + 3 more...
78 EBI-366083,EBI-1047804 FBXO11  
  .peptidyl-arginine N-methylation
.protein ubiquitination
.sensory perception of sound
  + 2 more...
.protein-arginine N-methyltransferase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
.nucleolus
.chromosome
  + 2 more...
79 EBI-366083,EBI-692891 HIPK1  
  .extrinsic apoptotic signaling pathway
.endothelial cell apoptotic process
.iris morphogenesis
  + 15 more...
.ATP binding
.protein serine/threonine kinase activity
.nuclear speck
.PML body
.cytoplasm
.nucleus
80 EBI-366083,EBI-1201460 MAPKAPK5  
  .stress-induced premature senescence
.protein autophosphorylation
.negative regulation of TOR signaling
  + 7 more...
.mitogen-activated protein kinase binding
.calcium-dependent protein serine/threonine kinase activity
.ATP binding
  + 6 more...
.cytoplasm
.nucleoplasm
81 EBI-366083,EBI-311123 CUL9  
  .protein ubiquitination
.regulation of mitotic nuclear division
.ubiquitin-dependent protein catabolic process
.microtubule cytoskeleton organization
.zinc ion binding
.ATP binding
.cullin-RING ubiquitin ligase complex
.cytoplasm
82 EBI-366083,EBI-2689959 KMT2E  
  .cellular response to retinoic acid
.histone H3-K4 methylation
.retinoic acid receptor signaling pathway
  + 9 more...
.histone methyltransferase activity (H3-K4 specific)
.enzyme binding
.zinc ion binding
.transcription coactivator activity
.MLL5-L complex
.intercellular bridge
.intracellular membrane-bounded organelle
  + 4 more...
83 EBI-366083,EBI-473160 PIAS4  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.positive regulation of keratinocyte apoptotic process
.negative regulation of transcription, DNA-templated
  + 8 more...
.SUMO ligase activity
.ubiquitin protein ligase binding
.SUMO transferase activity
  + 3 more...
.PML body
.nuclear matrix
.cytoplasm
  + 2 more...
84 EBI-366083,EBI-752324 RYBP  
  .histone H2A monoubiquitination
.multicellular organismal development
.apoptotic process
  + 2 more...
.zinc ion binding
.transcription corepressor activity
.DNA binding
.cytoplasm
.nucleoplasm
85 EBI-366083,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
86 EBI-366083,EBI-3923307 ZNF420  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.extracellular exosome
.nucleus
87 EBI-366083,EBI-81968 PARD3  
  .establishment of epithelial cell polarity
.tight junction assembly
.regulation of cellular localization
  + 18 more...
.phosphatidylinositol-3-phosphate binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.apical part of cell
.axonal growth cone
.protein complex
  + 11 more...
88 EBI-366083,EBI-1268586 SETD7  
  .heterochromatin organization
.peptidyl-lysine dimethylation
.peptidyl-lysine monomethylation
  + 5 more...
.histone-lysine N-methyltransferase activity
.protein-lysine N-methyltransferase activity
.p53 binding
.nucleolus
.chromosome
.nucleoplasm
89 EBI-366083,EBI-5550163 PPP1R13L  
  .cardiac muscle contraction
.multicellular organismal homeostasis
.hair cycle
  + 8 more...
.identical protein binding
.transcription factor binding
.transcription corepressor activity
.intercellular bridge
.cell junction
.cytoplasm
.nucleus
90 EBI-366083,EBI-81215 CREBBP  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.cellular response to hypoxia
  + 27 more...
.MRF binding
.acetyltransferase activity
.zinc ion binding
  + 14 more...
.nuclear body
.cytoplasm
.transcription factor complex
  + 5 more...
91 EBI-366083,EBI-746012 DDX17  
  .regulation of skeletal muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of intracellular estrogen receptor signaling pathway
  + 4 more...
.poly(A) RNA binding
.estrogen receptor binding
.RNA-dependent ATPase activity
  + 5 more...
.membrane
.cytoplasm
.nucleolus
  + 2 more...
92 EBI-366083,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
93 EBI-366083,EBI-302474 USP7  
  .regulation of proteasomal protein catabolic process
.regulation of sequence-specific DNA binding transcription factor activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 7 more...
.ubiquitin protein ligase binding
.transcription factor binding
.protein C-terminus binding
  + 3 more...
.PML body
.nuclear body
.cytosol
.nucleus
94 EBI-366083,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
95 EBI-366083,EBI-1058491 OTUB1  
  .negative regulation of double-strand break repair
.negative regulation of histone H2A K63-linked ubiquitination
.protein K48-linked deubiquitination
  + 3 more...
.ubiquitin binding
.ubiquitin protein ligase binding
.NEDD8-specific protease activity
.ubiquitin-specific protease activity
.extracellular exosome
.cytoplasm
96 EBI-366083,EBI-717460 TOE1  
  .N/A .metal ion binding
.nucleic acid binding
.nuclear speck
.nucleolus
.nucleoplasm
.nucleus
97 EBI-366083,EBI-536853 PBK  
  .negative regulation of inflammatory response
.cellular response to UV
.negative regulation of stress-activated MAPK cascade
  + 3 more...
.ATP binding
.protein serine/threonine kinase activity
.N/A
98 EBI-366083,EBI-947779 RCHY1  
  .error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
99 EBI-366083,EBI-625304 UHRF2  
  .regulation of methylation-dependent chromatin silencing
.positive regulation of cell cycle arrest
.protein autoubiquitination
  + 7 more...
.ubiquitin protein ligase activity
.histone binding
.ligase activity
  + 3 more...
.nuclear heterochromatin
.nucleoplasm
.nucleus
100 EBI-366083,EBI-539478 SRPK1  
  .regulation of mRNA processing
.regulation of mRNA splicing, via spliceosome
.innate immune response
  + 9 more...
.poly(A) RNA binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.nuclear matrix
.plasma membrane
.endoplasmic reticulum
  + 3 more...
101 EBI-366083,EBI-347218 SIN3A  
  .negative regulation of transcription regulatory region DNA binding
.negative regulation of histone H3-K27 acetylation
.negative regulation of protein localization to nucleus
  + 27 more...
.protein deacetylase activity
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.intercellular bridge
.transcriptional repressor complex
.Sin3 complex
  + 6 more...
102 EBI-366083,EBI-1769146 VRK1  
  .Golgi disassembly
.histone H3-T3 phosphorylation
.cell division
  + 10 more...
.histone kinase activity (H3-T3 specific)
.histone kinase activity (H3-S10 specific)
.nucleosomal histone binding
  + 4 more...
.cytosol
.spindle
.Golgi stack
  + 4 more...
103 EBI-366083,EBI-2924519 DUSP26  
  .positive regulation of peptidyl-serine dephosphorylation
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of cell adhesion
  + 4 more...
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.phosphoprotein phosphatase activity
  + 3 more...
.extracellular exosome
.Golgi apparatus
.mitochondrion
  + 2 more...
104 EBI-366083,EBI-711501 CCDC106  
  .N/A .N/A .cytoplasm
.nucleolus
.nucleoplasm
.nucleus
105 EBI-366083,EBI-710091 BTBD2  
  .N/A .N/A .cytoplasmic mRNA processing body
106 EBI-366083,EBI-2337775 TP63  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cellular senescence
.negative regulation of mesoderm development
  + 54 more...
.WW domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 10 more...
.dendrite
.cytosol
.rough endoplasmic reticulum
  + 6 more...
107 EBI-366083,EBI-896414 KAT8  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.histone H4-K16 acetylation
  + 7 more...
.metal ion binding
.methylated histone binding
.acetyltransferase activity
  + 2 more...
.MSL complex
.MLL1 complex
.nuclear membrane
  + 4 more...
108 EBI-366083,EBI-2513638 USP42  
  .regulation of proteasomal protein catabolic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
.cell differentiation
  + 2 more...
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.N/A
109 EBI-366083,EBI-711221 BRD7  
  .negative regulation of G1/S transition of mitotic cell cycle
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 6 more...
.lysine-acetylated histone binding
.transcription regulatory region DNA binding
.histone binding
  + 4 more...
.cytoplasm
.nucleus
110 EBI-366083,EBI-949911 CXXC1  
  .histone H3-K4 methylation
.positive regulation of transcription, DNA-templated
.cellular protein metabolic process
  + 4 more...
.unmethylated CpG binding
.zinc ion binding
.Set1C/COMPASS complex
.histone methyltransferase complex
.nuclear speck
  + 4 more...
111 EBI-366083,EBI-5651487 MAGEC2  
  .positive regulation of ubiquitin-protein transferase activity
.cellular protein catabolic process
.ubiquitin protein ligase binding .cytoplasm
.nucleus
112 EBI-366083,EBI-540797 ASH2L  
  .histone H3-K4 methylation
.positive regulation of transcription from RNA polymerase II promoter
.response to estrogen
  + 7 more...
.metal ion binding
.transcription regulatory region DNA binding
.DNA binding
.Set1C/COMPASS complex
.histone methyltransferase complex
.nucleoplasm
.nucleus
113 EBI-366083,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
114 EBI-366083,EBI-373524 MKRN1  
  .protein polyubiquitination .poly(A) RNA binding
.ligase activity
.zinc ion binding
  + 2 more...
.N/A
115 EBI-366083,EBI-751547 NOC2L  
  .negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of histone acetylation
.cellular response to UV
  + 6 more...
.repressing transcription factor binding
.poly(A) RNA binding
.histone binding
  + 3 more...
.nucleolus
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder301
blood40
bone41
brain20
cervix61
connective tissue60
embryonic tissue75
esophagus99
eye33
heart22
intestine125
kidney37
liver43
lung62
lymph90
lymph node133
mammary gland284
mouth529
muscle9
ovary68
pancreas14
pharynx98
placenta45
prostate89
salivary gland98
skin61
spleen280
stomach271
testis57
thymus213
thyroid171
trachea57
uterus120
vascular329
Health State
TissuesTPM*
normal17
adrenal tumor79
bladder carcinoma227
breast (mammary gland) tumor53
cervical tumor86
colorectal tumor177
esophageal tumor115
gastrointestinal tumor16
germ cell tumor87
glioma18
head and neck tumor97
kidney tumor43
leukemia84
liver tumor31
lung tumor38
lymphoma27
non-neoplasia20
ovarian tumor78
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
prostate cancer57
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor66
Developmental Stage
TissuesTPM*
adult16
embryoid body14
blastocyst97
neonate160
fetus14
infant42
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.1
adrenal gland9
appendix23.3
bone marrow10.3
cerebral cortex10.9
colon24.8
duodenum16.7
esophagus22.6
gallbladder13.9
heart muscle6.6
kidney11.7
liver8.3
lung15.2
lymph node30.6
ovary23.2
pancreas7.6
placenta22.3
prostate16.1
salivary gland9.6
skin28.7
small intestine15.9
spleen28.2
stomach19.6
testis11.8
thyroid gland17.1
urinary bladder24.1
Tissues
TissuesExpression level
duodenumLow
esophagusMedium
oral mucosaMedium
placentaLow
skin 1Low
skin 2Low
small intestineLow
testisLow
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#133239, phenotype) Esophageal cancerOMIM
2(#151623, phenotype) Li-fraumeni syndrome 1; LFS1OMIM
3(*191170, gene) Tumor protein p53; TP53OMIM
4(#202300, phenotype) Adrenocortical carcinoma, hereditary; ADCCOMIM
5(#211980, phenotype) Lung cancerOMIM
6(#260500, phenotype) Papilloma of choroid plexusOMIM
7(#275355, phenotype) Squamous cell carcinoma, head and neck; HNSCCOMIM
8(#614740, phenotype) Basal cell carcinoma, susceptibility to, 7; BCC7OMIM
9breast;colorectal;lung;sarcoma;adrenocortical;glioma;multiple other tumour types;adrenocortical carcinoma;Li-Fraumeni syndromeCGP


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