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> Protein (NX_P04731)
Protein (NX_P04731)
Protein
Gene SymbolMT1A to neXtProt (NX_P04731)
DescriptionMetallothionein-1A
Chromosome16
Location16q12.2 (56672578 ~ 56673999) to Ensembl
Sequene Features : Isoforms 1, Variants 5, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to zinc ion
.cellular response to cadmium ion
.negative regulation of growth
.zinc ion binding .perinuclear region of cytoplasm
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 5 1
2014-09-19protein level
1 4 1
2014-05-27protein level
1 4 1
2014-02-25protein level
1 4 1
2013-12-09protein level
1 4 1
2013-11-01protein level
1 4 1
2013-09-12protein level
1 4 1
2013-08-17protein level
1 4 1
2013-07-15protein level
1 3 1
2013-06-11protein level
1 3 1
2013-02-12protein level
1 2 1
2012-12-20protein level
1 2 1
2012-10-30protein level
1 2 1
2012-10-07protein level
1 2 1
2012-08-24protein level
1 2 1
2012-07-28protein level
1 2 1
2012-06-08protein level
1 2 1
2012-05-07protein level
1 2 1
2012-04-10protein level
1 2 1
2012-01-13protein level
1 2 1
2011-12-20protein level
1 2 1
2011-11-11protein level
1 2 1
2011-08-23protein level
1 2 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P04731-1
2 0 1 6115.1945
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8045030,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-8045030,EBI-8550965 GPR50  
  .cell-cell signaling
.G-protein coupled receptor signaling pathway
.identical protein binding
.melatonin receptor activity
.G-protein coupled receptor activity
.integral component of plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
connective tissue6
eye14
intestine181
liver9
lung8
uterus4
Health State
TissuesTPM*
normal2
colorectal tumor373
liver tumor10
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult23
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue41.3
adrenal gland14.3
appendix7.3
colon8.8
duodenum4.5
esophagus20.1
gallbladder15.3
heart muscle1.5
kidney1.3
liver16.6
lung3.3
ovary1.7
pancreas22.5
prostate2.9
small intestine13.9
stomach5.6
testis2
thyroid gland2.4
urinary bladder1.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineLow
colonHigh
duodenumHigh
endometrium 1High
esophagusMedium
gallbladderMedium
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverHigh
nasopharynxHigh
oral mucosaMedium
pancreasHigh
prostateHigh
rectumHigh
salivary glandLow
skin 2Medium
small intestineHigh
soft tissue 1Medium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*156350, gene) Metallothionein 1a; MT1AOMIM


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