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> Protein (NX_P04792)
Protein (NX_P04792)
Protein
Gene SymbolHSPB1 to neXtProt (NX_P04792)
DescriptionHeat shock protein beta-1
Chromosome7
Location7q11.23 (75931861 ~ 75933612) to Ensembl
Sequene Features : Isoforms 1, Variants 21, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of endothelial cell chemotaxis
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.platelet aggregation
  + 17 more...
.poly(A) RNA binding
.ubiquitin binding
.identical protein binding
  + 3 more...
.extracellular exosome
.Z disc
.focal adhesion
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 21 16
2014-09-19protein level
1 17 16
2014-05-27protein level
1 17 16
2014-02-25protein level
1 17 13
2013-12-09protein level
1 12 13
2013-11-01protein level
1 12 13
2013-09-12protein level
1 12 13
2013-08-17protein level
1 12 13
2013-07-15protein level
1 10 12
2013-06-11protein level
1 10 12
2013-02-12protein level
1 8 11
2012-12-20protein level
1 8 11
2012-10-30protein level
1 10 11
2012-10-07protein level
1 10 11
2012-08-24protein level
1 10 11
2012-07-28protein level
1 10 11
2012-06-08protein level
1 17 11
2012-05-07protein level
1 17 11
2012-04-10protein level
1 17 11
2012-01-13protein level
1 26 11
2011-12-20protein level
1 23 11
2011-11-11protein level
1 23 9
2011-08-23protein level
1 23 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P04792-1
10 0 0 22768.4282
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-352682,EBI-727171 DFFA  
  .negative regulation of apoptotic DNA fragmentation
.negative regulation of execution phase of apoptosis
.thymocyte apoptotic process
  + 5 more...
.N/A .cytosol
.cytoplasm
.nucleoplasm
  + 2 more...
2 EBI-352682,EBI-747185 BAG3  
  .regulation of cellular response to heat
.extrinsic apoptotic signaling pathway in absence of ligand
.cellular response to mechanical stimulus
  + 8 more...
.N/A .neuron projection
.Z disc
.plasma membrane
  + 2 more...
3 EBI-352682,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
4 EBI-352682,EBI-739060 CRYAB  
  .negative regulation of reactive oxygen species metabolic process
.cellular response to gamma radiation
.apoptotic process involved in morphogenesis
  + 18 more...
.unfolded protein binding
.metal ion binding
.protein homodimerization activity
  + 2 more...
.extracellular exosome
.actin filament bundle
.Z disc
  + 8 more...
5 EBI-352682,EBI-713259 FTH1  
  .membrane organization
.transmembrane transport
.negative regulation of fibroblast proliferation
  + 7 more...
.ferric iron binding
.iron ion binding
.ferroxidase activity
.extracellular exosome
.intracellular ferritin complex
.cytosol
.nucleus
6 EBI-352682,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
7 EBI-352682,EBI-353759 MME  
  .replicative senescence
.cellular response to UV-B
.cellular response to UV-A
  + 9 more...
.peptide binding
.zinc ion binding
.exopeptidase activity
  + 2 more...
.extracellular exosome
.synapse
.neuron projection terminus
  + 9 more...
8 EBI-352682,EBI-4289891 G6PD  
  .oxidation-reduction process
.glucose 6-phosphate metabolic process
.ribose phosphate biosynthetic process
  + 22 more...
.NADP binding
.protein homodimerization activity
.identical protein binding
  + 2 more...
.extracellular exosome
.intracellular membrane-bounded organelle
.membrane
  + 6 more...
9 EBI-352682,EBI-357997 XRCC5  
  .establishment of integrated proviral latency
.cellular response to X-ray
.cellular hyperosmotic salinity response
  + 17 more...
.poly(A) RNA binding
.transcription regulatory region DNA binding
.telomeric DNA binding
  + 7 more...
.nonhomologous end joining complex
.Ku70:Ku80 complex
.membrane
  + 7 more...
10 EBI-352682,EBI-1783169 TPT1  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of apoptotic process
.regulation of apoptotic process
  + 3 more...
.poly(A) RNA binding
.calcium ion binding
.extracellular exosome
.multivesicular body
.cytoplasm
  + 2 more...
11 EBI-352682,EBI-1049597 CALR  
  .positive regulation of dendritic cell chemotaxis
.positive regulation of substrate adhesion-dependent cell spreading
.cellular senescence
  + 42 more...
.chaperone binding
.unfolded protein binding
.androgen receptor binding
  + 14 more...
.endocytic vesicle lumen
.integral component of lumenal side of endoplasmic reticulum membrane
.extracellular exosome
  + 20 more...
12 EBI-352682,EBI-993299 MAPKAPK2  
  .regulation of cellular response to heat
.3'-UTR-mediated mRNA stabilization
.stress-activated MAPK cascade
  + 37 more...
.mitogen-activated protein kinase binding
.calcium-dependent protein serine/threonine kinase activity
.ATP binding
  + 5 more...
.extracellular exosome
.cytosol
.centrosome
  + 3 more...
13 EBI-352682,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
14 EBI-352682,EBI-1055954 IGBP1  
  .negative regulation of apoptotic signaling pathway
.response to interleukin-1
.regulation of microtubule-based movement
  + 11 more...
.protein phosphatase 2A binding
.protein phosphatase type 2A regulator activity
.microtubule
.cytosol
.cytoplasm
15 EBI-352682,EBI-296519 EIF4G2  
  .cytokine-mediated signaling pathway
.cell death
.cell cycle arrest
.regulation of translational initiation
.poly(A) RNA binding
.translation factor activity, RNA binding
.translation initiation factor activity
.eukaryotic translation initiation factor 4F complex
.membrane
.cytosol
16 EBI-352682,EBI-712083 GSTO1  
  .glutathione derivative biosynthetic process
.cellular response to arsenic-containing substance
.positive regulation of ryanodine-sensitive calcium-release channel activity
  + 8 more...
.methylarsonate reductase activity
.glutathione dehydrogenase (ascorbate) activity
.oxidoreductase activity
.glutathione transferase activity
.extracellular exosome
.cytosol
.cytoplasm
17 EBI-352682,EBI-1047444 FKBP4  
  .regulation of cellular response to heat
.chaperone-mediated protein folding
.male sex differentiation
  + 12 more...
.poly(A) RNA binding
.heat shock protein binding
.protein binding, bridging
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.axonal growth cone
  + 7 more...
18 EBI-352682,EBI-1051880 SF3A3  
  .gene expression
.RNA splicing
.mRNA processing
  + 3 more...
.poly(A) RNA binding
.zinc ion binding
.catalytic step 2 spliceosome
.nuclear speck
.spliceosomal complex
.nucleoplasm
19 EBI-352682,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
20 EBI-352682,EBI-73473 EIF4A2  
  .negative regulation of RNA-directed RNA polymerase activity
.cellular protein metabolic process
.cytokine-mediated signaling pathway
  + 8 more...
.poly(A) RNA binding
.ATPase activity
.ATP binding
  + 3 more...
.perinuclear region of cytoplasm
.eukaryotic translation initiation factor 4F complex
.cytosol
.nucleolus
21 EBI-352682,EBI-357897 EFTUD2  
  .gene expression
.RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.GTP binding
.GTPase activity
.catalytic step 2 spliceosome
.nuclear speck
.membrane
  + 4 more...
22 EBI-352682,EBI-1384657 MAPKAPK3  
  .stress-activated MAPK cascade
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 24 more...
.mitogen-activated protein kinase binding
.calcium-dependent protein serine/threonine kinase activity
.ATP binding
  + 5 more...
.nuclear membrane
.cytosol
.cytoplasm
  + 2 more...
23 EBI-352682,EBI-625934 HUWE1  
  .positive regulation of protein targeting to mitochondrion
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.cell differentiation
  + 4 more...
.poly(A) RNA binding
.ligase activity
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.membrane
.cytoplasm
  + 2 more...
24 EBI-352682,EBI-4401730 RAB43  
  .phagosome maturation
.retrograde transport, plasma membrane to Golgi
.Rab protein signal transduction
  + 4 more...
.GTP binding
.GTPase activity
.extracellular exosome
.phagocytic vesicle
.phagocytic vesicle membrane
  + 2 more...
25 EBI-352682,EBI-1201460 MAPKAPK5  
  .stress-induced premature senescence
.protein autophosphorylation
.negative regulation of TOR signaling
  + 7 more...
.mitogen-activated protein kinase binding
.calcium-dependent protein serine/threonine kinase activity
.ATP binding
  + 6 more...
.cytoplasm
.nucleoplasm
26 EBI-352682,EBI-2607770 PAF1  
  .cellular response to lipopolysaccharide
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of myeloid cell differentiation
  + 13 more...
.chromatin binding
.RNA polymerase II core binding
.Cdc73/Paf1 complex
.membrane
.cytoplasm
27 EBI-352682,EBI-4399372 PGM2  
  .deoxyribose phosphate catabolic process
.small molecule metabolic process
.galactose catabolic process
  + 4 more...
.phosphopentomutase activity
.phosphoglucomutase activity
.magnesium ion binding
.extracellular exosome
.cytosol
28 EBI-352682,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
29 EBI-352682,EBI-739074 HSPB8  
  .N/A .identical protein binding .Golgi apparatus
.cytoplasm
.nucleoplasm
  + 2 more...
30 EBI-352682,EBI-727129 SPIN1  
  .meiotic cell cycle
.positive regulation of Wnt signaling pathway
.chromatin modification
  + 4 more...
.methylated histone binding .spindle
.nucleolus
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland273
ascites1205
bladder736
blood40
bone279
bone marrow102
brain201
cervix164
connective tissue167
embryonic tissue272
esophagus793
eye512
heart793
intestine482
kidney336
larynx383
liver204
lung456
lymph22
lymph node311
mammary gland469
mouth362
muscle1175
nerve579
ovary955
pancreas824
parathyroid388
pharynx24
pituitary gland121
placenta385
prostate258
salivary gland493
skin616
spleen56
stomach324
testis57
thymus50
thyroid214
trachea19
umbilical cord145
uterus581
vascular271
Health State
TissuesTPM*
normal281
adrenal tumor395
bladder carcinoma1364
breast (mammary gland) tumor590
cervical tumor173
chondrosarcoma338
colorectal tumor106
esophageal tumor927
gastrointestinal tumor835
germ cell tumor155
glioma1110
head and neck tumor343
kidney tumor624
leukemia31
liver tumor364
lung tumor768
lymphoma27
non-neoplasia258
ovarian tumor1050
pancreatic tumor1171
primitive neuroectodermal tumor of the CNS133
prostate cancer240
retinoblastoma258
skin tumor677
soft tissue/muscle tissue tumor327
uterine tumor366
Developmental Stage
TissuesTPM*
adult463
embryoid body242
blastocyst488
neonate64
fetus211
infant42
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue215.2
adrenal gland164.5
appendix175.5
bone marrow28.3
cerebral cortex37.7
colon149.9
duodenum105
esophagus655.2
gallbladder141.6
heart muscle521.6
kidney196.7
liver76.1
lung151.3
lymph node64.9
ovary124.7
pancreas67.2
placenta226.3
prostate288.7
salivary gland150.2
skin562.8
small intestine65.7
spleen85.1
stomach152.5
testis47.8
thyroid gland95.6
urinary bladder230.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastLow
bronchusHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
kidneyMedium
liverLow
lungMedium
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
stomach 1Medium
stomach 2Medium
testisLow
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602195, gene) Heat-shock 27-kd protein 1; HSPB1OMIM
2(#606595, phenotype) Charcot-marie-tooth disease, axonal, type 2f; CMT2FOMIM
3(#608634, phenotype) Neuronopathy, distal hereditary motor, type iib; HMN2BOMIM


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