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> Protein (NX_P04899)
Protein (NX_P04899)
Protein
Gene SymbolGNAI2 to neXtProt (NX_P04899)
DescriptionGuanine nucleotide-binding protein G(i) subunit alpha-2
Chromosome3
Location3p21.31 (50263724 ~ 50296787) to Ensembl
Sequene Features : Isoforms 6, Variants 35, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of calcium ion transport
.cell division
.negative regulation of synaptic transmission
  + 17 more...
.metal ion binding
.G-protein beta/gamma-subunit complex binding
.GTP binding
  + 3 more...
.extracellular exosome
.membrane raft
.vesicle
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 35 7
2014-09-19protein level
6 26 7
2014-05-27protein level
6 26 13
2014-02-25protein level
4 25 13
2013-12-09protein level
4 22 13
2013-11-01protein level
4 21 10
2013-09-12protein level
4 21 10
2013-08-17protein level
4 21 10
2013-07-15protein level
4 12 6
2013-06-11protein level
4 12 6
2013-02-12protein level
4 8 17
2012-12-20protein level
4 8 17
2012-10-30protein level
4 10 17
2012-10-07protein level
4 10 6
2012-08-24protein level
4 9 6
2012-07-28protein level
4 9 6
2012-06-08protein level
4 0 6
2012-05-07protein level
3 5 6
2012-04-10protein level
2 5 6
2012-01-13protein level
2 3 6
2011-12-20protein level
2 3 6
2011-11-11protein level
2 3 6
2011-08-23protein level
2 3 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P04899-1
0 11 7 40424.941
NX_P04899-2
1 10 6 38447.7416
NX_P04899-3
0 10 6 36441.8707
NX_P04899-4
1 11 6 41521.508
NX_P04899-5
1 10 6 38711.9546
NX_P04899-6
0 10 6 34912.0769
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-353997,EBI-10178530 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
2 EBI-353997,EBI-395044 NCF1  
  .phagosome maturation
.neutrophil mediated killing of fungus
.neutrophil mediated killing of gram-positive bacterium
  + 21 more...
.phosphatidylinositol-3,4-bisphosphate binding
.phosphatidylinositol binding
.SH3 domain binding
  + 2 more...
.neuronal cell body
.NADPH oxidase complex
.phagolysosome
  + 5 more...
3 EBI-353997,EBI-489611 NCF2  
  .phagosome maturation
.response to hyperoxia
.interaction with host
  + 20 more...
.electron carrier activity
.protein C-terminus binding
.NADPH oxidase complex
.phagolysosome
.cytosol
  + 3 more...
4 EBI-353997,EBI-2835269 CXCR5  
  .lymph node development
.B cell activation
.positive regulation of cytokinesis
  + 4 more...
.C-X-C chemokine receptor activity
.G-protein coupled receptor activity
.external side of plasma membrane
.integral component of plasma membrane
.plasma membrane
5 EBI-353997,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
6 EBI-353997,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
7 EBI-353997,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
8 EBI-353997,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
9 EBI-353997,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
10 EBI-353997,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
11 EBI-353997,EBI-347538 GPSM3  
  .regulation of G-protein coupled receptor protein signaling pathway .GDP-dissociation inhibitor activity .cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland273
ascites75
bladder66
blood744
bone307
bone marrow123
brain192
cervix164
connective tissue288
ear62
embryonic tissue234
esophagus99
eye287
heart111
intestine146
kidney251
larynx213
liver58
lung238
lymph293
lymph node167
mammary gland390
mouth105
muscle47
nerve386
ovary325
pancreas201
parathyroid48
pharynx24
pituitary gland60
placenta279
prostate189
salivary gland49
skin593
spleen280
stomach94
testis151
thymus138
thyroid343
tonsil1351
trachea19
umbilical cord145
uterus327
vascular348
Health State
TissuesTPM*
normal189
adrenal tumor553
bladder carcinoma56
breast (mammary gland) tumor504
cervical tumor173
chondrosarcoma338
colorectal tumor168
esophageal tumor115
gastrointestinal tumor92
germ cell tumor136
glioma167
head and neck tumor179
kidney tumor392
leukemia793
liver tumor62
lung tumor350
lymphoma263
non-neoplasia331
ovarian tumor223
pancreatic tumor399
primitive neuroectodermal tumor of the CNS212
prostate cancer260
retinoblastoma301
skin tumor789
soft tissue/muscle tissue tumor263
uterine tumor399
Developmental Stage
TissuesTPM*
adult260
embryoid body242
blastocyst146
neonate321
fetus104
infant85
juvenile359
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue168.8
adrenal gland97.1
appendix194.7
bone marrow208.8
cerebral cortex93.8
colon73.8
duodenum59.7
esophagus109.4
gallbladder155.2
heart muscle117.9
kidney67.1
liver77.5
lung195.8
lymph node220.5
ovary133.7
pancreas30.2
placenta183.8
prostate96
salivary gland43.9
skin72
small intestine71
spleen237.6
stomach65.6
testis87.4
thyroid gland95.9
urinary bladder191
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*139360, gene) Guanine nucleotide-binding protein, alpha-inhibiting activity polypeptideOMIM


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