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> Protein (NX_P05060)
Protein (NX_P05060)
Protein
Gene SymbolCHGB to neXtProt (NX_P05060)
DescriptionSecretogranin-1
Chromosome20
Location20p12.3 (5892076 ~ 5906007) to Ensembl
Sequene Features : Isoforms 1, Variants 155, PTMs 27 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .hormone activity .secretory granule
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 155 27
2014-09-19protein level
1 107 27
2014-05-27protein level
1 107 27
2014-02-25protein level
1 104 27
2013-12-09protein level
1 90 27
2013-11-01protein level
1 82 27
2013-09-12protein level
1 82 28
2013-08-17protein level
1 82 28
2013-07-15protein level
1 63 28
2013-06-11protein level
1 63 28
2013-02-12protein level
1 31 29
2012-12-20protein level
1 30 29
2012-10-30protein level
1 32 29
2012-10-07protein level
1 32 29
2012-08-24protein level
1 31 29
2012-07-28protein level
1 31 29
2012-06-08protein level
1 34 29
2012-05-07protein level
1 25 29
2012-04-10protein level
1 25 29
2012-01-13protein level
1 16 29
2011-12-20protein level
1 16 29
2011-11-11protein level
1 16 29
2011-08-23protein level
1 16 29
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P05060-1
37 0 0 78228.9747
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-712619,EBI-1040141 SMAD2  
  .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
2 EBI-712619,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland1942
brain277
embryonic tissue14
eye38
heart11
intestine12
kidney61
lung59
mammary gland6
mouth60
muscle37
nerve321
pancreas801
parathyroid242
pituitary gland2722
prostate5
stomach10
testis32
thymus12
trachea38
Health State
TissuesTPM*
normal145
adrenal tumor2212
breast (mammary gland) tumor10
colorectal tumor8
germ cell tumor102
glioma37
head and neck tumor37
kidney tumor188
lung tumor77
non-neoplasia41
pancreatic tumor704
primitive neuroectodermal tumor of the CNS448
Developmental Stage
TissuesTPM*
adult59
embryoid body14
fetus73
infant42
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.7
adrenal gland2063.6
appendix3.9
cerebral cortex85.6
colon9.6
duodenum46.6
heart muscle20.5
kidney5.9
lymph node2.7
ovary15.4
pancreas39.5
prostate4.2
small intestine25.3
stomach134.9
testis15
thyroid gland1.7
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
cerebral cortexMedium
colonMedium
duodenumMedium
hippocampusMedium
pancreasHigh
prostateLow
rectumMedium
small intestineMedium
stomach 1Medium
stomach 2Medium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*118920, gene) Chromogranin b; CHGBOMIM


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