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> Protein (NX_P05067)
Protein (NX_P05067)
Protein
Gene SymbolAPP to neXtProt (NX_P05067)
DescriptionAmyloid beta A4 protein
Chromosome21
Location21q21.3 (27252861 ~ 27543446) to Ensembl
Sequene Features : Isoforms 11, Variants 133, PTMs 41 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane organization
.smooth endoplasmic reticulum calcium ion homeostasis
.neuron apoptotic process
  + 41 more...
.PTB domain binding
.transition metal ion binding
.identical protein binding
  + 7 more...
.extracellular exosome
.spindle midzone
.perinuclear region of cytoplasm
  + 27 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
11 133 41
2014-09-19protein level
11 106 41
2014-05-27protein level
11 106 42
2014-02-25protein level
11 105 42
2013-12-09protein level
11 83 43
2013-11-01protein level
11 80 40
2013-09-12protein level
11 80 40
2013-08-17protein level
11 80 39
2013-07-15protein level
11 46 29
2013-06-11protein level
11 46 29
2013-02-12protein level
10 33 253
2012-12-20protein level
10 33 253
2012-10-30protein level
10 33 253
2012-10-07protein level
10 33 25
2012-08-24protein level
10 31 25
2012-07-28protein level
10 31 25
2012-06-08protein level
10 72 25
2012-05-07protein level
10 72 25
2012-04-10protein level
10 72 25
2012-01-13protein level
10 74 25
2011-12-20protein level
10 74 25
2011-11-11protein level
10 74 26
2011-08-23protein level
10 74 19
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P05067-1
0 35 1 86887.8125
NX_P05067-10
1 26 1 72507.3259
NX_P05067-11
1 31 1 84467.3788
NX_P05067-2
1 12 0 34335.8916
NX_P05067-3
0 29 1 76711.1328
NX_P05067-4
0 30 1 78613.1342
NX_P05067-5
0 30 1 78816.3109
NX_P05067-6
0 31 1 80718.3123
NX_P05067-7
0 32 1 82862.6765
NX_P05067-8
0 33 1 84764.6779
NX_P05067-9
0 34 1 84985.8111
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-77613,EBI-81694 APBB1  
  .negative regulation of thymidylate synthase biosynthetic process
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 17 more...
.proline-rich region binding
.histone binding
.transcription factor binding
  + 2 more...
.synapse
.growth cone
.lamellipodium
  + 4 more...
2 EBI-302641,EBI-2431769 ITM2A  
  .N/A .N/A .integral component of membrane
3 EBI-77613,EBI-2313231 TNFRSF21  
  .negative regulation of interleukin-10 secretion
.negative regulation of interleukin-13 secretion
.negative regulation of interleukin-5 secretion
  + 15 more...
.N/A .intrinsic component of plasma membrane
.axon
.integral component of plasma membrane
.plasma membrane
4 EBI-77613,EBI-603643 FLOT1  
  .positive regulation of protein stabilization
.protein localization to membrane raft
.establishment of protein localization to plasma membrane
  + 13 more...
.protease binding .extracellular exosome
.membrane raft
.melanosome
  + 10 more...
5 EBI-77613,EBI-852851 FOS  
  .cellular response to calcium ion
.SMAD protein signal transduction
.response to cAMP
  + 44 more...
.R-SMAD binding
.transcription regulatory region DNA binding
.transcription factor binding
  + 3 more...
.neuron projection
.membrane
.cytosol
  + 4 more...
6 EBI-77613,EBI-779636 TGFB1  
  .positive regulation of transcription regulatory region DNA binding
.regulation of actin cytoskeleton reorganization
.positive regulation of NAD+ ADP-ribosyltransferase activity
  + 151 more...
.type III transforming growth factor beta receptor binding
.type I transforming growth factor beta receptor binding
.enzyme binding
  + 4 more...
.blood microparticle
.neuronal cell body
.platelet alpha granule lumen
  + 9 more...
7 EBI-77613,EBI-701692 APOA1  
  .positive regulation of substrate adhesion-dependent cell spreading
.cholesterol import
.triglyceride homeostasis
  + 61 more...
.high-density lipoprotein particle receptor binding
.phosphatidylcholine-sterol O-acyltransferase activator activity
.lipase inhibitor activity
  + 12 more...
.blood microparticle
.endocytic vesicle lumen
.extracellular exosome
  + 17 more...
8 EBI-821758,EBI-1246249 MT-ND3  
  .small molecule metabolic process
.cellular metabolic process
.respiratory electron transport chain
.mitochondrial electron transport, NADH to ubiquinone
.NADH dehydrogenase (ubiquinone) activity .integral component of membrane
.mitochondrial respiratory chain complex I
.mitochondrial inner membrane
9 EBI-77613,EBI-977302 PRNP  
  .regulation of potassium ion transmembrane transport
.cellular response to copper ion
.negative regulation of calcineurin-NFAT signaling cascade
  + 17 more...
.identical protein binding
.tubulin binding
.microtubule binding
.copper ion binding
.extracellular exosome
.membrane raft
.anchored component of membrane
  + 7 more...
10 EBI-77613,EBI-852823 JUN  
  .positive regulation of DNA-templated transcription, initiation
.negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.cellular response to calcium ion
  + 60 more...
.R-SMAD binding
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 15 more...
.transcriptional repressor complex
.cytosol
.nuclear euchromatin
  + 4 more...
11 EBI-77613,EBI-475646 NEFL  
  .response to corticosterone
.protein polymerization
.neuromuscular process controlling balance
  + 15 more...
.identical protein binding
.protein binding, bridging
.protein C-terminus binding
.structural constituent of cytoskeleton
.growth cone
.axon
.neurofilament
  + 2 more...
12 EBI-77613,EBI-2115097 CTSD  
  .collagen catabolic process
.extracellular matrix organization
.protein catabolic process
  + 4 more...
.aspartic-type endopeptidase activity .extracellular exosome
.membrane raft
.lysosomal lumen
  + 4 more...
13 EBI-77613,EBI-1387782 NGFR  
  .regulation of glucose import in response to insulin stimulus
.positive regulation of apoptotic signaling pathway
.apoptotic signaling pathway
  + 21 more...
.ubiquitin protein ligase binding
.Rab GTPase binding
.death receptor activity
  + 3 more...
.neuronal postsynaptic density
.cell surface
.integral component of plasma membrane
  + 5 more...
14 EBI-77613,EBI-366182 MAPT  
  .regulation of microtubule-based movement
.generation of neurons
.axon extension
  + 13 more...
.lipoprotein particle binding
.apolipoprotein binding
.enzyme binding
  + 3 more...
.tubulin complex
.cytoplasmic ribonucleoprotein granule
.nuclear periphery
  + 7 more...
15 EBI-77613,EBI-1172917 NF1  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.cognition
  + 60 more...
.phosphatidylcholine binding
.phosphatidylethanolamine binding
.GTPase activator activity
.intrinsic component of the cytoplasmic side of the plasma membrane
.dendrite
.axon
  + 4 more...
16 EBI-77613,EBI-1049597 CALR  
  .positive regulation of dendritic cell chemotaxis
.positive regulation of substrate adhesion-dependent cell spreading
.cellular senescence
  + 42 more...
.chaperone binding
.unfolded protein binding
.androgen receptor binding
  + 14 more...
.endocytic vesicle lumen
.integral component of lumenal side of endoplasmic reticulum membrane
.extracellular exosome
  + 20 more...
17 EBI-77613,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
18 EBI-77613,EBI-979862 PDIA3  
  .positive regulation of extrinsic apoptotic signaling pathway
.oxidation-reduction process
.cell redox homeostasis
  + 13 more...
.poly(A) RNA binding
.disulfide oxidoreductase activity
.phospholipase C activity
  + 2 more...
.extracellular exosome
.melanosome
.cell surface
  + 5 more...
19 EBI-821758,EBI-2566375 COL18A1  
  .positive regulation of endothelial cell apoptotic process
.response to hydrostatic pressure
.response to drug
  + 11 more...
.metal ion binding
.identical protein binding
.structural molecule activity
.extracellular exosome
.extracellular matrix
.endoplasmic reticulum lumen
  + 4 more...
20 EBI-302641,EBI-3909653 GPR3  
  .regulation of meiotic nuclear division
.positive regulation of cAMP metabolic process
.positive regulation of cytosolic calcium ion concentration
.adenylate cyclase-activating G-protein coupled receptor signaling pathway
.G-protein coupled receptor activity .integral component of plasma membrane
21 EBI-77613,EBI-297277 PSEN1  
  .negative regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.calcium ion transmembrane transport
  + 65 more...
.cadherin binding
.PDZ domain binding
.beta-catenin binding
  + 3 more...
.gamma-secretase complex
.perinuclear region of cytoplasm
.membrane raft
  + 29 more...
22 EBI-302641,EBI-74648 APLP1  
  .cellular response to norepinephrine stimulus
.forebrain development
.negative regulation of cAMP biosynthetic process
  + 9 more...
.transition metal ion binding
.identical protein binding
.alpha-2C adrenergic receptor binding
  + 3 more...
.perinuclear region of cytoplasm
.integral component of membrane
.plasma membrane
  + 2 more...
23 EBI-77613,EBI-740475 PCBD1  
  .protein heterooligomerization
.protein homotetramerization
.positive regulation of transcription, DNA-templated
  + 6 more...
.identical protein binding
.4-alpha-hydroxytetrahydrobiopterin dehydratase activity
.phenylalanine 4-monooxygenase activity
.transcription coactivator activity
.extracellular exosome
.cytosol
.cytoplasm
.nucleoplasm
24 EBI-77613,EBI-779581 TGFB2  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of extracellular matrix organization
.extrinsic apoptotic signaling pathway
  + 82 more...
.protein heterodimerization activity
.protein homodimerization activity
.type III transforming growth factor beta receptor binding
  + 6 more...
.neuronal cell body
.platelet alpha granule lumen
.extracellular matrix
  + 4 more...
25 EBI-77613,EBI-368690 APBA1  
  .multicellular organism growth
.gamma-aminobutyric acid secretion
.glutamate secretion
  + 10 more...
.phosphatidylinositol-4,5-bisphosphate binding
.beta-amyloid binding
.perinuclear region of cytoplasm
.protein complex
.synaptic vesicle
  + 4 more...
26 EBI-302641,EBI-79306 APLP2  
  .neuromuscular process controlling balance
.regulation of protein binding
.midbrain development
  + 9 more...
.transition metal ion binding
.identical protein binding
.heparin binding
  + 2 more...
.extracellular exosome
.integral component of membrane
.membrane
  + 2 more...
27 EBI-302641,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
28 EBI-77613,EBI-77642 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
29 EBI-302641,EBI-718504 BLMH  
  .response to drug
.response to toxic substance
.proteolysis
  + 2 more...
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.carboxypeptidase activity
.aminopeptidase activity
.extracellular exosome
.cytosol
.cytoplasm
  + 2 more...
30 EBI-821758,EBI-8869614 PCOLCE  
  .positive regulation of peptidase activity
.multicellular organismal development
.proteolysis
.peptidase activator activity
.heparin binding
.collagen binding
.extracellular exosome
.extracellular space
31 EBI-77613,EBI-79084 SHC3  
  .neurotrophin TRK receptor signaling pathway
.synaptic transmission, glutamatergic
.insulin receptor signaling pathway
  + 5 more...
.receptor tyrosine kinase binding
.protein kinase binding
.signal transducer activity
.plasma membrane
.cytosol
32 EBI-77613,EBI-79277 APBB2  
  .negative regulation of apoptotic process
.positive regulation of apoptotic process
.intracellular signal transduction
  + 6 more...
.transcription factor binding
.beta-amyloid binding
.synapse
.growth cone
.lamellipodium
  + 3 more...
33 EBI-77613,EBI-394357 MED12  
  .axis elongation involved in somitogenesis
.Wnt signaling pathway, planar cell polarity pathway
.canonical Wnt signaling pathway
  + 12 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 9 more...
.mediator complex
.membrane
.centrosome
  + 3 more...
34 EBI-77613,EBI-476263 MAP3K5  
  .cellular response to reactive nitrogen species
.positive regulation of neuron death
.programmed necrotic cell death
  + 18 more...
.protein homodimerization activity
.protein phosphatase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 4 more...
.IRE1-TRAF2-ASK1 complex
.protein kinase complex
.cytosol
35 EBI-77613,EBI-79964 HSD17B10  
  .small molecule metabolic process
.cellular nitrogen compound metabolic process
.branched-chain amino acid catabolic process
  + 2 more...
.3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
.poly(A) RNA binding
.testosterone dehydrogenase [NAD(P)] activity
  + 2 more...
.plasma membrane
.endoplasmic reticulum
.mitochondrial matrix
  + 3 more...
36 EBI-302641,EBI-2431846 SPON1  
  .cellular protein metabolic process
.post-translational protein modification
.protein O-linked fucosylation
  + 2 more...
.N/A .endoplasmic reticulum lumen
.extracellular space
.proteinaceous extracellular matrix
37 EBI-77613,EBI-725153 SLC40A1  
  .multicellular organismal iron ion homeostasis
.spleen trabecula formation
.transmembrane transport
  + 8 more...
.iron ion transmembrane transporter activity .basolateral plasma membrane
.integral component of membrane
.synaptic vesicle
  + 5 more...
38 EBI-302661,EBI-748420 HOMER3  
  .regulation of store-operated calcium entry
.G-protein coupled glutamate receptor signaling pathway
.protein targeting
.G-protein coupled glutamate receptor binding .neuronal postsynaptic density
.postsynaptic membrane
.basal part of cell
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland364
ascites301
bladder301
blood139
bone265
bone marrow20
brain766
cervix329
connective tissue281
ear1242
embryonic tissue511
esophagus99
eye493
heart245
intestine754
kidney426
larynx852
liver77
lung271
lymph node22
mammary gland634
mouth634
muscle94
nerve450
ovary295
pancreas445
parathyroid291
pharynx294
pituitary gland726
placenta289
prostate174
salivary gland49
skin237
spleen56
stomach407
testis553
thymus188
thyroid1867
trachea714
umbilical cord290
uterus336
vascular348
Health State
TissuesTPM*
normal426
adrenal tumor474
bladder carcinoma568
breast (mammary gland) tumor601
cervical tumor463
chondrosarcoma350
colorectal tumor1173
esophageal tumor115
gastrointestinal tumor379
germ cell tumor604
glioma317
head and neck tumor1143
kidney tumor566
leukemia179
liver tumor62
lung tumor214
non-neoplasia362
ovarian tumor315
pancreatic tumor609
primitive neuroectodermal tumor of the CNS94
prostate cancer134
retinoblastoma107
skin tumor183
soft tissue/muscle tissue tumor175
uterine tumor366
Developmental Stage
TissuesTPM*
adult610
embryoid body757
blastocyst520
neonate225
fetus364
infant85
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue194.6
adrenal gland410.7
appendix142.7
bone marrow94.4
cerebral cortex518
colon296.7
duodenum174.4
esophagus181.9
gallbladder370.2
heart muscle294.4
kidney398
liver163.6
lung282
lymph node81.4
ovary273.3
pancreas140.8
placenta325.6
prostate215.5
salivary gland136
skin191
small intestine160.2
spleen127.9
stomach173.6
testis184.3
thyroid gland442.7
urinary bladder328.1
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowLow
breastLow
cerebellumLow
cerebral cortexMedium
colonMedium
duodenumLow
endometrium 2Low
epididymisLow
gallbladderLow
hippocampusMedium
lateral ventricleMedium
pancreasLow
placentaLow
prostateLow
rectumLow
seminal vesicleLow
small intestineLow
testisLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#104300, phenotype) Alzheimer disease; ADOMIM
2(*104760, gene) Amyloid beta a4 precursor protein; APPOMIM
3(#605714, phenotype) Cerebral amyloid angiopathy, app-relatedOMIM


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