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> Protein (NX_P05109)
Protein (NX_P05109)
Protein
Gene SymbolS100A8 to neXtProt (NX_P05109)
DescriptionProtein S100-A8
Chromosome1
Location1q21.3 (153362508 ~ 153363664) to Ensembl
Sequene Features : Isoforms 1, Variants 19, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.neutrophil aggregation
.regulation of cytoskeleton organization
  + 22 more...
.RAGE receptor binding
.arachidonic acid binding
.Toll-like receptor 4 binding
  + 3 more...
.extracellular exosome
.plasma membrane
.cytoskeleton
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 19 2
2014-09-19protein level
1 11 2
2014-05-27protein level
1 11 2
2014-02-25protein level
1 11 2
2013-12-09protein level
1 9 2
2013-11-01protein level
1 8 2
2013-09-12protein level
1 8 2
2013-08-17protein level
1 8 2
2013-07-15protein level
1 5 2
2013-06-11protein level
1 5 2
2013-02-12protein level
1 1 1
2012-12-20protein level
1 1 1
2012-10-30protein level
1 1 1
2012-10-07protein level
1 1 0
2012-08-24protein level
1 0 0
2012-07-28protein level
1 0 0
2012-06-08protein level
1 2 0
2012-05-07protein level
1 5 0
2012-04-10protein level
1 5 0
2012-01-13protein level
1 2 0
2011-12-20protein level
1 2 0
2011-11-11protein level
1 2 0
2011-08-23protein level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P05109-1
4 0 0 10827.6184
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-355281,EBI-354056 GAPDH  
  .cellular response to interferon-gamma
.canonical glycolysis
.neuron apoptotic process
  + 8 more...
.NAD binding
.NADP binding
.identical protein binding
  + 3 more...
.GAIT complex
.extracellular exosome
.perinuclear region of cytoplasm
  + 11 more...
2 EBI-355281,EBI-1055001 S100A9  
  .positive regulation of intrinsic apoptotic signaling pathway
.neutrophil aggregation
.regulation of cytoskeleton organization
  + 24 more...
.RAGE receptor binding
.arachidonic acid binding
.Toll-like receptor 4 binding
  + 5 more...
.extracellular exosome
.plasma membrane
.cytoskeleton
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder33
blood498
bone13
bone marrow1272
brain3
cervix41
connective tissue13
esophagus248
eye23
heart55
intestine12
kidney9
larynx511
liver19
lung65
mammary gland6
mouth1360
muscle150
nerve64
ovary9
pancreas9
pharynx1718
placenta24
prostate5
skin33
spleen93
stomach41
testis11
uterus77
vascular58
Health State
TissuesTPM*
normal61
bladder carcinoma113
breast (mammary gland) tumor10
cervical tumor57
colorectal tumor17
esophageal tumor289
head and neck tumor881
leukemia571
liver tumor41
lung tumor116
non-neoplasia124
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
skin tumor31
soft tissue/muscle tissue tumor7
uterine tumor77
Developmental Stage
TissuesTPM*
adult108
fetus25
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue214.9
adrenal gland19.2
appendix665.5
bone marrow3380.3
cerebral cortex6.9
colon24.8
duodenum12.1
esophagus3589.6
gallbladder56.6
heart muscle22
kidney5.1
liver113.1
lung86.9
lymph node18.5
ovary2.2
pancreas18.4
placenta79.3
prostate9.4
salivary gland15.2
skin109.9
small intestine12
spleen372.9
stomach13
testis7.7
thyroid gland6.9
urinary bladder140.5
Tissues
TissuesExpression level
appendixMedium
bone marrowHigh
cervix, uterineMedium
esophagusHigh
lymph nodeMedium
oral mucosaHigh
skin 2High
spleenMedium
tonsilHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*123885, gene) S100 calcium-binding protein a8; S100A8OMIM


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