Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P05121)
Protein (NX_P05121)
Protein
Gene SymbolSERPINE1 to neXtProt (NX_P05121)
DescriptionPlasminogen activator inhibitor 1
Chromosome7
Location7q22.1 (100770370 ~ 100782547) to Ensembl
Sequene Features : Isoforms 2, Variants 60, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of endothelial cell apoptotic process
.negative regulation of smooth muscle cell-matrix adhesion
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 33 more...
.receptor binding
.serine-type endopeptidase inhibitor activity
.protease binding
.extracellular exosome
.platelet alpha granule lumen
.extracellular matrix
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 60 3
2014-09-19protein level
2 50 3
2014-05-27protein level
2 50 3
2014-02-25protein level
2 49 3
2013-12-09protein level
2 43 3
2013-11-01protein level
2 42 3
2013-09-12protein level
2 42 3
2013-08-17protein level
2 42 3
2013-07-15protein level
2 26 3
2013-06-11protein level
2 26 3
2013-02-12protein level
1 14 3
2012-12-20protein level
1 14 3
2012-10-30protein level
1 14 3
2012-10-07protein level
1 14 3
2012-08-24protein level
1 13 3
2012-07-28protein level
1 12 3
2012-06-08protein level
1 18 3
2012-05-07protein level
1 15 3
2012-04-10protein level
1 15 3
2012-01-13protein level
1 14 3
2011-12-20protein level
1 14 3
2011-11-11protein level
1 14 3
2011-08-23protein level
1 14 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P05121-1
2 19 0 45030.9047
NX_P05121-2
1 19 0 43376.0515
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-953978,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
2 EBI-953978,EBI-976767 ORM1  
  .negative regulation of tumor necrosis factor production
.negative regulation of interleukin-6 production
.inflammatory response
  + 3 more...
.N/A .blood microparticle
.extracellular exosome
.extracellular space
.extracellular region
3 EBI-953978,EBI-744081 SGTB  
  .N/A .N/A .N/A
4 EBI-953978,EBI-741480 UBQLN1  
  .regulation of autophagic vacuole assembly
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.identical protein binding
.polyubiquitin binding
.kinase binding
.perinuclear region of cytoplasm
.protein complex
.aggresome
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder33
blood16
bone446
bone marrow410
brain18
cervix61
connective tissue275
embryonic tissue32
esophagus49
eye76
heart11
intestine25
kidney52
larynx42
liver306
lung164
lymph node11
mammary gland39
muscle37
nerve193
ovary49
pancreas248
pharynx24
placenta745
prostate5
skin441
stomach125
testis11
thymus37
thyroid257
umbilical cord2397
uterus64
vascular1297
Health State
TissuesTPM*
normal12
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma700
colorectal tumor17
esophageal tumor57
gastrointestinal tumor92
germ cell tumor15
glioma65
head and neck tumor7
liver tumor20
lung tumor9
ovarian tumor13
pancreatic tumor66
skin tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult7
embryoid body100
blastocyst97
neonate997
fetus7
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue117.9
adrenal gland62.1
appendix75.2
cerebral cortex5.9
colon9.6
duodenum6.2
esophagus15
gallbladder302.2
heart muscle6
kidney7.3
liver297.1
lung24.5
lymph node18.6
ovary81.1
pancreas59.5
placenta338.6
prostate15.3
small intestine3.7
spleen7.4
stomach10.6
testis6.3
thyroid gland24.2
urinary bladder121
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*173360, gene) Serpin peptidase inhibitor, clade e (nexin, plasminogen activatorOMIM
2(#613329, phenotype) Plasminogen activator inhibitor-1 deficiencyOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center