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> Protein (NX_P05198)
Protein (NX_P05198)
Protein
Gene SymbolEIF2S1 to neXtProt (NX_P05198)
DescriptionEukaryotic translation initiation factor 2 subunit 1
Chromosome14
Location14q23.3 (67826714 ~ 67853233) to Ensembl
Sequene Features : Isoforms 1, Variants 25, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of mitophagy in response to mitochondrial depolarization
.transmembrane transport
.protein autophosphorylation
  + 8 more...
.poly(A) RNA binding
.ribosome binding
.translation initiation factor activity
.extracellular exosome
.multi-eIF complex
.eukaryotic 48S preinitiation complex
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 25 15
2014-09-19protein level
1 18 15
2014-05-27protein level
1 18 15
2014-02-25protein level
1 18 15
2013-12-09protein level
1 12 15
2013-11-01protein level
1 12 13
2013-09-12protein level
1 12 13
2013-08-17protein level
1 12 13
2013-07-15protein level
1 8 6
2013-06-11protein level
1 8 6
2013-02-12protein level
1 4 3
2012-12-20protein level
1 4 3
2012-10-30protein level
1 5 3
2012-10-07protein level
1 5 3
2012-08-24protein level
1 5 3
2012-07-28protein level
1 5 3
2012-06-08protein level
1 5 3
2012-05-07protein level
1 2 3
2012-04-10protein level
1 2 3
2012-01-13protein level
1 3 3
2011-12-20protein level
1 3 3
2011-11-11protein level
1 3 3
2011-08-23protein level
1 3 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P05198-1
18 0 0 36089.2721
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1056162,EBI-353779 DDX3X  
  .negative regulation of intrinsic apoptotic signaling pathway
.positive regulation of G1/S transition of mitotic cell cycle
.intrinsic apoptotic signaling pathway
  + 28 more...
.mRNA 5'-UTR binding
.poly(A) RNA binding
.CTPase activity
  + 14 more...
.extracellular exosome
.nuclear speck
.cytoplasmic stress granule
  + 4 more...
2 EBI-1056162,EBI-640775 EIF2AK2  
  .regulation of hematopoietic stem cell differentiation
.regulation of hematopoietic stem cell proliferation
.regulation of hematopoietic progenitor cell differentiation
  + 27 more...
.poly(A) RNA binding
.protein phosphatase type 2A regulator activity
.ATP binding
  + 5 more...
.perinuclear region of cytoplasm
.membrane
.ribosome
  + 3 more...
3 EBI-1056162,EBI-711977 EIF2S2  
  .transmembrane transport
.cellular protein metabolic process
.gene expression
  + 5 more...
.metal ion binding
.poly(A) RNA binding
.translation factor activity, RNA binding
  + 2 more...
.eukaryotic translation initiation factor 2 complex
.cytosol
.cytoplasm
4 EBI-1056162,EBI-1054228 EIF2S3  
  .transmembrane transport
.cellular protein metabolic process
.gene expression
  + 2 more...
.translation factor activity, RNA binding
.GTP binding
.GTPase activity
.translation initiation factor activity
.extracellular exosome
.cytosol
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland30
ascites50
bladder133
blood171
bone349
bone marrow123
brain77
cervix41
connective tissue80
ear124
embryonic tissue136
esophagus49
eye76
heart44
intestine99
kidney90
larynx255
liver102
lung110
lymph90
lymph node233
mammary gland185
mouth60
muscle37
ovary49
pancreas42
pharynx368
pituitary gland121
placenta158
prostate94
salivary gland98
skin71
spleen37
stomach324
testis107
thymus75
thyroid21
tonsil58
trachea77
uterus60
vascular58
Health State
TissuesTPM*
normal96
adrenal tumor79
breast (mammary gland) tumor236
chondrosarcoma193
colorectal tumor124
esophageal tumor57
gastrointestinal tumor126
germ cell tumor121
glioma55
head and neck tumor104
kidney tumor87
leukemia95
liver tumor135
lung tumor116
lymphoma152
non-neoplasia41
ovarian tumor39
pancreatic tumor38
primitive neuroectodermal tumor of the CNS283
prostate cancer134
retinoblastoma86
skin tumor71
soft tissue/muscle tissue tumor79
uterine tumor44
Developmental Stage
TissuesTPM*
adult112
embryoid body114
blastocyst97
fetus104
infant212
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue58.8
adrenal gland49.9
appendix73.1
bone marrow31.3
cerebral cortex46
colon60.3
duodenum40.5
esophagus63.7
gallbladder31.2
heart muscle43.2
kidney57.6
liver48.1
lung34.2
lymph node54
ovary28.9
pancreas25.7
placenta55.5
prostate46.4
salivary gland32.8
skin24.5
small intestine45.1
spleen43.7
stomach52.5
testis66.6
thyroid gland41.1
urinary bladder36.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603907, gene) Eukaryotic translation initiation factor 2, subunit 1; EIF2S1OMIM


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