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> Protein (NX_P05412)
Protein (NX_P05412)
Protein
Gene SymbolJUN to neXtProt (NX_P05412)
DescriptionTranscription factor AP-1
Chromosome1
Location1p32.1 (59246465 ~ 59249785) to Ensembl
Sequene Features : Isoforms 1, Variants 26, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of DNA-templated transcription, initiation
.negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.cellular response to calcium ion
  + 60 more...
.R-SMAD binding
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 15 more...
.transcriptional repressor complex
.cytosol
.nuclear euchromatin
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 26 16
2014-09-19protein level
1 18 16
2014-05-27protein level
1 18 16
2014-02-25protein level
1 17 15
2013-12-09protein level
1 12 15
2013-11-01protein level
1 12 13
2013-09-12protein level
1 12 13
2013-08-17protein level
1 12 13
2013-07-15protein level
1 10 13
2013-06-11protein level
1 10 13
2013-02-12protein level
1 2 13
2012-12-20protein level
1 2 13
2012-10-30protein level
1 4 13
2012-10-07protein level
1 4 13
2012-08-24protein level
1 4 13
2012-07-28protein level
1 4 13
2012-06-08protein level
1 15 13
2012-05-07protein level
1 14 13
2012-04-10protein level
1 14 13
2012-01-13protein level
1 14 13
2011-12-20protein level
1 14 13
2011-11-11protein level
1 14 14
2011-08-23protein level
1 9 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P05412-1
9 0 1 35653.0582
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-852823,EBI-625002 CREB3  
  .negative regulation of ligand-dependent nuclear receptor transcription coactivator activity
.negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.positive regulation of deacetylase activity
  + 19 more...
.protein dimerization activity
.protein homodimerization activity
.cAMP response element binding
  + 9 more...
.neuronal cell body
.integral component of endoplasmic reticulum membrane
.nuclear body
  + 9 more...
2 EBI-852823,EBI-852851 FOS  
  .cellular response to calcium ion
.SMAD protein signal transduction
.response to cAMP
  + 44 more...
.R-SMAD binding
.transcription regulatory region DNA binding
.transcription factor binding
  + 3 more...
.neuron projection
.membrane
.cytosol
  + 4 more...
3 EBI-852823,EBI-77613 APP  
  .membrane organization
.smooth endoplasmic reticulum calcium ion homeostasis
.neuron apoptotic process
  + 41 more...
.PTB domain binding
.transition metal ion binding
.identical protein binding
  + 7 more...
.extracellular exosome
.spindle midzone
.perinuclear region of cytoplasm
  + 27 more...
4 EBI-852823,EBI-296047 HSP90AA1  
  .regulation of cellular response to heat
.positive regulation of cardiac muscle contraction
.chaperone-mediated protein complex assembly
  + 26 more...
.GTPase binding
.poly(A) RNA binding
.protein homodimerization activity
  + 12 more...
.endocytic vesicle lumen
.extracellular exosome
.perinuclear region of cytoplasm
  + 17 more...
5 EBI-852823,EBI-913209 ETS1  
  .response to interleukin-1
.cellular response to hydrogen peroxide
.angiogenesis involved in wound healing
  + 24 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.intercellular bridge
.cytoplasm
.transcription factor complex
  + 2 more...
6 EBI-852823,EBI-1170906 ATF2  
  .positive regulation of mitochondrial membrane permeability involved in apoptotic process
.adipose tissue development
.stress-activated MAPK cascade
  + 27 more...
.metal ion binding
.cAMP response element binding
.protein kinase binding
  + 13 more...
.site of double-strand break
.mitochondrial outer membrane
.cytoplasm
  + 2 more...
7 EBI-852823,EBI-744510 FOSL1  
  .positive regulation of DNA-templated transcription, initiation
.placenta blood vessel development
.response to cAMP
  + 22 more...
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II regulatory region sequence-specific DNA binding
.neuron projection
.presynaptic membrane
.cytosol
  + 2 more...
8 EBI-852823,EBI-492498 ATF4  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of oxidative stress-induced neuron death
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  + 21 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 9 more...
.CHOP-ATF4 complex
.ATF1-ATF4 transcription factor complex
.ATF4-CREB1 transcription factor complex
  + 8 more...
9 EBI-852823,EBI-286483 MAPK8  
  .positive regulation of determination of dorsal identity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.programmed necrotic cell death
  + 45 more...
.histone deacetylase binding
.histone deacetylase regulator activity
.enzyme binding
  + 3 more...
.cytosol
.mitochondrion
.nucleoplasm
.nucleus
10 EBI-852823,EBI-347545 PRRC2A  
  .N/A .poly(A) RNA binding .extracellular exosome
.intracellular membrane-bounded organelle
.membrane
  + 2 more...
11 EBI-852823,EBI-349938 KPNA2  
  .cytokine-mediated signaling pathway
.viral process
.NLS-bearing protein import into nucleus
  + 2 more...
.poly(A) RNA binding
.histone deacetylase binding
.protein transporter activity
.nuclear localization sequence binding
.membrane
.cytosol
.cytoplasm
.nucleoplasm
12 EBI-852823,EBI-713543 MAPK10  
  .stress-activated MAPK cascade
.regulation of sequence-specific DNA binding transcription factor activity
.rhythmic process
  + 21 more...
.ATP binding
.MAP kinase kinase activity
.JUN kinase activity
.plasma membrane
.cytosol
.mitochondrion
  + 2 more...
13 EBI-852823,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
14 EBI-852823,EBI-79306 APLP2  
  .neuromuscular process controlling balance
.regulation of protein binding
.midbrain development
  + 9 more...
.transition metal ion binding
.identical protein binding
.heparin binding
  + 2 more...
.extracellular exosome
.integral component of membrane
.membrane
  + 2 more...
15 EBI-852823,EBI-10087113 NFATC2  
  .B cell receptor signaling pathway
.positive regulation of transcription, DNA-templated
.innate immune response
  + 8 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
  + 2 more...
.nuclear transcription factor complex
.ribonucleoprotein complex
.actin cytoskeleton
  + 5 more...
16 EBI-852823,EBI-1806001 BBS7  
  .cilium morphogenesis
.limb development
.palate development
  + 18 more...
.RNA polymerase II repressing transcription factor binding .ciliary membrane
.ciliary basal body
.BBSome
  + 5 more...
17 EBI-852823,EBI-2624951 CITED1  
  .response to transforming growth factor beta
.response to parathyroid hormone
.response to interleukin-11
  + 38 more...
.co-SMAD binding
.LBD domain binding
.transcription regulatory region DNA binding
  + 5 more...
.cytosol
.cytoplasm
.nucleus
18 EBI-852823,EBI-1769146 VRK1  
  .Golgi disassembly
.histone H3-T3 phosphorylation
.cell division
  + 10 more...
.histone kinase activity (H3-T3 specific)
.histone kinase activity (H3-S10 specific)
.nucleosomal histone binding
  + 4 more...
.cytosol
.spindle
.Golgi stack
  + 4 more...
19 EBI-852823,EBI-717245 STRN4  
  .N/A .armadillo repeat domain binding
.protein phosphatase 2A binding
.protein complex binding
.calmodulin binding
.protein complex
.dendritic spine
.membrane
.cytoplasm
20 EBI-852823,EBI-726739 MAPRE3  
  .positive regulation of microtubule plus-end binding
.cell division
.positive regulation of transcription, DNA-templated
  + 2 more...
.microtubule binding .perinuclear region of cytoplasm
.microtubule plus-end
.midbody
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue1321
adrenal gland60
ascites2384
blood98
bone125
bone marrow102
brain87
cervix123
connective tissue73
ear124
embryonic tissue46
esophagus49
eye129
heart178
intestine202
kidney147
liver43
lung218
lymph node66
mammary gland178
muscle56
nerve1094
ovary226
pancreas459
parathyroid1262
pituitary gland60
placenta123
prostate205
skin71
stomach104
testis50
thymus50
thyroid85
uterus254
vascular77
Health State
TissuesTPM*
normal223
adrenal tumor79
breast (mammary gland) tumor53
chondrosarcoma181
colorectal tumor115
esophageal tumor57
gastrointestinal tumor886
germ cell tumor49
glioma429
head and neck tumor22
kidney tumor174
leukemia127
liver tumor52
lung tumor38
non-neoplasia62
ovarian tumor236
pancreatic tumor209
primitive neuroectodermal tumor of the CNS23
prostate cancer202
retinoblastoma43
skin tumor79
soft tissue/muscle tissue tumor63
uterine tumor432
Developmental Stage
TissuesTPM*
adult318
embryoid body71
blastocyst48
fetus165
infant85
juvenile305
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue156.9
adrenal gland71.8
appendix30.6
bone marrow127.9
cerebral cortex34.3
colon61.7
duodenum31.4
esophagus73.4
gallbladder95.7
heart muscle24.6
kidney80
liver107.4
lung71.4
lymph node44.1
ovary120.7
pancreas44.7
placenta28.6
prostate190
salivary gland124.6
skin7.1
small intestine54.5
spleen78.1
stomach67.5
testis23.8
thyroid gland131.7
urinary bladder58.8
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisLow
esophagusHigh
fallopian tubeMedium
gallbladderHigh
kidneyHigh
lungHigh
nasopharynxMedium
oral mucosaHigh
placentaMedium
rectumMedium
salivary glandLow
skin 1Low
skin 2High
small intestineMedium
smooth muscleLow
stomach 1Medium
stomach 2Medium
thyroid glandHigh
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*165160, gene) V-jun avian sarcoma virus 17 oncogene homolog; JUNOMIM
2sarcomaCGP


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