Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P05549)
Protein (NX_P05549)
Protein
Gene SymbolTFAP2A to neXtProt (NX_P05549)
DescriptionTranscription factor AP-2-alpha
Chromosome6
Location6p24.3 (10393419 ~ 10419892) to Ensembl
Sequene Features : Isoforms 4, Variants 67, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of reactive oxygen species metabolic process
.metanephric nephron development
.basement membrane organization
  + 43 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 14 more...
.intracellular membrane-bounded organelle
.centrosome
.Golgi apparatus
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 67 2
2014-09-19protein level
4 48 2
2014-05-27protein level
4 48 3
2014-02-25protein level
4 47 3
2013-12-09protein level
4 38 3
2013-11-01protein level
4 35 3
2013-09-12protein level
4 35 3
2013-08-17protein level
4 35 3
2013-07-15protein level
3 16 3
2013-06-11protein level
3 16 3
2013-02-12protein level
3 8 8
2012-12-20protein level
3 8 8
2012-10-30protein level
3 8 8
2012-10-07protein level
3 8 3
2012-08-24protein level
3 4 3
2012-07-28protein level
3 4 3
2012-06-08protein level
3 5 3
2012-05-07protein level
3 5 3
2012-04-10protein level
2 5 3
2012-01-13protein level
2 10 3
2011-12-20protein level
2 10 3
2011-11-11protein level
2 10 3
2011-08-23protein level
2 10 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P05549-1
0 11 7 48032.2481
NX_P05549-2
5 7 4 40531.7867
NX_P05549-5
1 11 7 47153.8482
NX_P05549-6
0 11 7 47410.985
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347351,EBI-78579 NPM1  
  .regulation of eIF2 alpha phosphorylation by dsRNA
.regulation of endoribonuclease activity
.protein oligomerization
  + 20 more...
.unfolded protein binding
.NF-kappaB binding
.protein heterodimerization activity
  + 10 more...
.spindle pole centrosome
.ribonucleoprotein complex
.membrane
  + 7 more...
2 EBI-347351,EBI-80168 UBE2I  
  .positive regulation of SUMO transferase activity
.cell division
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 14 more...
.RING-like zinc finger domain binding
.SUMO conjugating enzyme activity
.poly(A) RNA binding
  + 6 more...
.sumoylated E2 ligase complex
.transferase complex
.synapse
  + 7 more...
3 EBI-347351,EBI-447295 EP300  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.regulation of tubulin deacetylation
  + 40 more...
.pre-mRNA intronic binding
.androgen receptor binding
.nuclear hormone receptor binding
  + 17 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
  + 2 more...
4 EBI-347351,EBI-2340269 MKRN3  
  .protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
5 EBI-347351,EBI-10194609 GSTO2  
  .glutathione derivative biosynthetic process
.cellular response to arsenic-containing substance
.oxidation-reduction process
  + 5 more...
.methylarsonate reductase activity
.glutathione dehydrogenase (ascorbate) activity
.oxidoreductase activity
.glutathione transferase activity
.extracellular exosome
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bone27
brain3
cervix206
embryonic tissue61
eye134
kidney23
liver48
lung32
lymph node11
mammary gland198
mouth45
nerve64
ovary39
pancreas9
placenta243
prostate15
salivary gland98
skin123
stomach41
testis9
trachea19
uterus4
vascular19
Health State
TissuesTPM*
normal46
adrenal tumor79
breast (mammary gland) tumor75
cervical tumor144
chondrosarcoma24
gastrointestinal tumor42
germ cell tumor26
glioma18
head and neck tumor37
kidney tumor14
liver tumor104
lung tumor19
non-neoplasia51
ovarian tumor39
pancreatic tumor19
prostate cancer19
skin tumor111
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult72
embryoid body42
blastocyst32
fetus25
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
esophagus15.7
kidney8.5
placenta43.3
prostate9.5
salivary gland17.1
skin52
stomach1.7
testis2.2
urinary bladder2.8
Tissues
TissuesExpression level
breastLow
cervix, uterineMedium
esophagusMedium
kidneyLow
oral mucosaMedium
placentaHigh
skin 1Medium
skin 2Medium
tonsilMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*107580, gene) Transcription factor ap2-alpha; TFAP2AOMIM
2(#113620, phenotype) Branchiooculofacial syndrome; BOFSOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2020 (C) Yonsei Proteome Research Center