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> Protein (NX_P05556)
Protein (NX_P05556)
Protein
Gene SymbolITGB1 to neXtProt (NX_P05556)
DescriptionIntegrin beta-1
Chromosome10
Location10p11.22 (33189247 ~ 33294720) to Ensembl
Sequene Features : Isoforms 5, Variants 94, PTMs 51 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of anoikis
.positive regulation of establishment of protein localization to plasma membrane
.response to transforming growth factor beta
  + 57 more...
.collagen binding involved in cell-matrix adhesion
.cell adhesion molecule binding
.protein heterodimerization activity
  + 5 more...
.synaptic membrane
.invadopodium membrane
.extracellular exosome
  + 32 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 94 51
2014-09-19protein level
5 76 51
2014-05-27protein level
5 76 51
2014-02-25protein level
5 75 51
2013-12-09protein level
5 53 51
2013-11-01protein level
5 52 51
2013-09-12protein level
5 52 52
2013-08-17protein level
5 52 52
2013-07-15protein level
5 34 47
2013-06-11protein level
5 34 47
2013-02-12protein level
5 9 215
2012-12-20protein level
5 10 215
2012-10-30protein level
5 12 215
2012-10-07protein level
5 12 49
2012-08-24protein level
5 5 49
2012-07-28protein level
5 5 49
2012-06-08protein level
5 7 49
2012-05-07protein level
5 7 49
2012-04-10protein level
5 7 49
2012-01-13protein level
5 7 49
2011-12-20protein level
5 12 49
2011-11-11protein level
5 12 48
2011-08-23protein level
5 12 47
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P05556-1
2 35 0 88356.7663
NX_P05556-2
0 35 0 87388.3085
NX_P05556-3
1 36 0 91559.4145
NX_P05556-4
1 36 0 90974.104
NX_P05556-5
1 35 0 88824.9994
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-703066,EBI-704216 FABP3  
  .positive regulation of phospholipid biosynthetic process
.response to fatty acid
.phospholipid homeostasis
  + 9 more...
.oleic acid binding
.icosatetraenoic acid binding
.long-chain fatty acid binding
  + 2 more...
.extracellular exosome
.sarcoplasm
.cytosol
.extracellular space
2 EBI-703066,EBI-79452 LYN  
  .positive regulation of dendritic cell apoptotic process
.negative regulation of intracellular signal transduction
.dendritic cell differentiation
  + 83 more...
.ion channel binding
.glycosphingolipid binding
.enzyme binding
  + 5 more...
.extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 11 more...
3 EBI-703066,EBI-703044 ITGA4  
  .negative regulation of protein homodimerization activity
.T cell migration
.chorio-allantoic fusion
  + 18 more...
.cell adhesion molecule binding
.metal ion binding
.extracellular exosome
.integrin alpha4-beta7 complex
.membrane
  + 5 more...
4 EBI-703066,EBI-702960 ITGA2  
  .hepatocyte differentiation
.positive regulation of phagocytosis, engulfment
.positive regulation of transmission of nerve impulse
  + 39 more...
.collagen binding involved in cell-matrix adhesion
.metal ion binding
.collagen receptor activity
  + 2 more...
.perinuclear region of cytoplasm
.basal part of cell
.axon terminus
  + 8 more...
5 EBI-703066,EBI-2834630 ENG  
  .response to transforming growth factor beta
.cellular response to mechanical stimulus
.detection of hypoxia
  + 42 more...
.transforming growth factor beta binding
.activin binding
.protein homodimerization activity
  + 7 more...
.endothelial microparticle
.transforming growth factor beta receptor homodimeric complex
.receptor complex
  + 6 more...
6 EBI-703066,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
7 EBI-703066,EBI-350432 FLNA  
  .positive regulation of integrin-mediated signaling pathway
.positive regulation of substrate adhesion-dependent cell spreading
.mitotic spindle assembly
  + 24 more...
.actin filament binding
.Rac GTPase binding
.poly(A) RNA binding
  + 8 more...
.apical dendrite
.extracellular exosome
.perinuclear region of cytoplasm
  + 15 more...
8 EBI-703066,EBI-1809771 CSF2RB  
  .interleukin-3-mediated signaling pathway
.interleukin-5-mediated signaling pathway
.cellular response to interleukin-3
  + 3 more...
.cytokine receptor activity
.receptor activity
.granulocyte macrophage colony-stimulating factor receptor complex
.integral component of plasma membrane
.plasma membrane
9 EBI-6082935,EBI-702209 PXN  
  .growth hormone receptor signaling pathway
.branching morphogenesis of an epithelial tube
.focal adhesion assembly
  + 16 more...
.vinculin binding
.zinc ion binding
.beta-catenin binding
.lamellipodium
.cell cortex
.focal adhesion
  + 6 more...
10 EBI-703066,EBI-2968146 ANGPTL4  
  .negative regulation of endothelial cell apoptotic process
.triglyceride homeostasis
.protein homooligomerization
  + 8 more...
.enzyme inhibitor activity .blood microparticle
.extracellular space
.proteinaceous extracellular matrix
.extracellular region
11 EBI-703066,EBI-2462036 TLN1  
  .platelet aggregation
.cellular protein metabolic process
.IRE1-mediated unfolded protein response
  + 12 more...
.LIM domain binding
.vinculin binding
.structural constituent of cytoskeleton
.integrin binding
.extracellular exosome
.ruffle membrane
.cell surface
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland182
ascites627
bladder234
blood81
bone446
bone marrow225
brain155
cervix82
connective tissue778
ear559
embryonic tissue723
esophagus49
eye119
heart290
intestine288
kidney251
larynx213
liver253
lung259
lymph67
lymph node100
mammary gland284
mouth453
muscle808
nerve321
ovary157
pancreas295
parathyroid388
pharynx270
placenta279
prostate242
salivary gland197
skin336
spleen131
stomach188
testis183
thymus112
thyroid236
trachea753
umbilical cord1017
uterus379
vascular1200
Health State
TissuesTPM*
normal285
adrenal tumor316
bladder carcinoma284
breast (mammary gland) tumor300
cervical tumor115
chondrosarcoma120
colorectal tumor373
esophageal tumor57
gastrointestinal tumor396
germ cell tumor208
glioma121
head and neck tumor358
kidney tumor188
leukemia84
liver tumor260
lung tumor214
lymphoma83
non-neoplasia486
ovarian tumor183
pancreatic tumor285
primitive neuroectodermal tumor of the CNS31
prostate cancer337
retinoblastoma43
skin tumor143
soft tissue/muscle tissue tumor606
uterine tumor199
Developmental Stage
TissuesTPM*
adult334
embryoid body1500
blastocyst423
neonate997
fetus138
infant42
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue306.8
adrenal gland136.1
appendix184.7
bone marrow34.2
cerebral cortex34.4
colon175.3
duodenum100.4
esophagus126.6
gallbladder267.7
heart muscle231.7
kidney112.7
liver109.2
lung173.2
lymph node87.5
ovary109
pancreas50.6
placenta256.6
prostate163.4
salivary gland73.7
skin55.3
small intestine105.6
spleen124.6
stomach90.4
testis80
thyroid gland121.5
urinary bladder255.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumLow
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverHigh
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2Medium
testisHigh
thyroid glandLow
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*135630, gene) Integrin, beta-1; ITGB1OMIM


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