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> Protein (NX_P05783)
Protein (NX_P05783)
Protein
Gene SymbolKRT18 to neXtProt (NX_P05783)
DescriptionKeratin, type I cytoskeletal 18
Chromosome12
Location12q13.13 (53342655 ~ 53346685) to Ensembl
Sequene Features : Isoforms 1, Variants 55, PTMs 38 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.intermediate filament cytoskeleton organization
  + 6 more...
.scaffold protein binding
.poly(A) RNA binding
.structural molecule activity
.cell periphery
.extracellular exosome
.perinuclear region of cytoplasm
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 55 38
2014-09-19protein level
1 41 38
2014-05-27protein level
1 41 38
2014-02-25protein level
1 40 37
2013-12-09protein level
1 30 37
2013-11-01protein level
1 29 33
2013-09-12protein level
1 29 34
2013-08-17protein level
1 29 34
2013-07-15protein level
1 24 35
2013-06-11protein level
1 24 35
2013-02-12protein level
1 17 37
2012-12-20protein level
1 17 37
2012-10-30protein level
1 14 37
2012-10-07protein level
1 14 37
2012-08-24protein level
1 14 37
2012-07-28protein level
1 14 37
2012-06-08protein level
1 38 37
2012-05-07protein level
1 38 37
2012-04-10protein level
1 38 37
2012-01-13protein level
1 65 37
2011-12-20protein level
1 65 37
2011-11-11protein level
1 65 32
2011-08-23protein level
1 65 32
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P05783-1
18 0 2 48028.3963
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-297888,EBI-1053164 DNAJB6  
  .regulation of cellular response to heat
.negative regulation of inclusion body assembly
.chorion development
  + 11 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
  + 2 more...
.perinuclear region of cytoplasm
.Z disc
.membrane
  + 4 more...
2 EBI-297888,EBI-297852 KRT8  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.cell differentiation involved in embryonic placenta development
  + 5 more...
.scaffold protein binding
.structural molecule activity
.extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 10 more...
3 EBI-297888,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
4 EBI-297888,EBI-9087684 PKP1  
  .intermediate filament bundle assembly
.single organismal cell-cell adhesion
.programmed cell death
  + 5 more...
.structural constituent of epidermis
.intermediate filament binding
.lamin binding
.signal transducer activity
.extracellular exosome
.intracellular membrane-bounded organelle
.desmosome
  + 4 more...
5 EBI-297888,EBI-359215 TRADD  
  .regulation of extrinsic apoptotic signaling pathway via death domain receptors
.programmed necrotic cell death
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
  + 17 more...
.death domain binding
.binding, bridging
.identical protein binding
  + 2 more...
.membrane raft
.receptor complex
.death-inducing signaling complex
  + 4 more...
6 EBI-297888,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
7 EBI-297888,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
8 EBI-297888,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
ascites1456
bladder368
blood49
bone181
bone marrow430
brain19
cervix886
connective tissue26
embryonic tissue1357
esophagus3671
eye464
heart100
intestine2534
kidney322
larynx383
liver1222
lung627
lymph67
lymph node100
mammary gland1990
mouth75
muscle9
ovary1192
pancreas2408
parathyroid48
pharynx24
pituitary gland484
placenta1540
prostate907
salivary gland49
skin336
spleen56
stomach804
testis36
thyroid644
tonsil58
umbilical cord290
uterus788
vascular38
Health State
TissuesTPM*
normal265
bladder carcinoma227
breast (mammary gland) tumor3126
cervical tumor1043
chondrosarcoma60
colorectal tumor4817
esophageal tumor4291
gastrointestinal tumor1004
germ cell tumor1018
glioma93
head and neck tumor216
kidney tumor580
leukemia232
liver tumor2186
lung tumor1634
lymphoma41
non-neoplasia175
ovarian tumor1430
pancreatic tumor4723
primitive neuroectodermal tumor of the CNS47
prostate cancer1377
retinoblastoma86
skin tumor518
soft tissue/muscle tissue tumor23
uterine tumor1942
Developmental Stage
TissuesTPM*
adult642
embryoid body2372
blastocyst911
neonate128
fetus77
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.2
adrenal gland4.6
appendix33.3
colon126.9
duodenum100.3
esophagus18.7
gallbladder76.6
heart muscle6.2
kidney38
liver120.8
lung63.2
lymph node5.5
ovary6.1
pancreas60.1
placenta150.4
prostate68.1
salivary gland84.4
skin2.4
small intestine115.8
spleen9.1
stomach94.7
testis5.4
thyroid gland86.4
urinary bladder41.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
breastHigh
bronchusHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
fallopian tubeHigh
gallbladderHigh
kidneyHigh
liverHigh
lungHigh
nasopharynxHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
small intestineHigh
stomach 1High
stomach 2High
thyroid glandHigh
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*148070, gene) Keratin 18; KRT18OMIM
2(#215600, phenotype) Cirrhosis, familialOMIM


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