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> Protein (NX_P05787)
Protein (NX_P05787)
Protein
Gene SymbolKRT8 to neXtProt (NX_P05787)
DescriptionKeratin, type II cytoskeletal 8
Chromosome12
Location12q13.13 (53290977 ~ 53343738) to Ensembl
Sequene Features : Isoforms 2, Variants 59, PTMs 56 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.cell differentiation involved in embryonic placenta development
  + 5 more...
.scaffold protein binding
.structural molecule activity
.extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 59 56
2014-09-19protein level
2 43 56
2014-05-27protein level
2 43 63
2014-02-25protein level
2 43 57
2013-12-09protein level
2 38 57
2013-11-01protein level
2 38 47
2013-09-12protein level
2 38 47
2013-08-17protein level
2 38 47
2013-07-15protein level
2 29 47
2013-06-11protein level
2 29 47
2013-02-12protein level
1 19 48
2012-12-20protein level
1 18 48
2012-10-30protein level
1 18 48
2012-10-07protein level
1 18 48
2012-08-24protein level
1 15 48
2012-07-28protein level
1 14 48
2012-06-08protein level
1 32 48
2012-05-07protein level
1 32 48
2012-04-10protein level
1 32 48
2012-01-13protein level
1 43 47
2011-12-20protein level
1 43 47
2011-11-11protein level
1 43 43
2011-08-23protein level
1 45 41
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P05787-1
0 22 4 53670.9787
NX_P05787-2
1 22 4 56573.2942
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-297852,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
2 EBI-297852,EBI-297888 KRT18  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.intermediate filament cytoskeleton organization
  + 6 more...
.scaffold protein binding
.poly(A) RNA binding
.structural molecule activity
.cell periphery
.extracellular exosome
.perinuclear region of cytoplasm
  + 6 more...
3 EBI-297852,EBI-349854 CFTR  
  .positive regulation of voltage-gated chloride channel activity
.chloride transmembrane transport
.cellular response to cAMP
  + 20 more...
.PDZ domain binding
.enzyme binding
.chloride channel inhibitor activity
  + 6 more...
.extracellular exosome
.recycling endosome
.protein complex
  + 11 more...
4 EBI-297852,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
5 EBI-297852,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
6 EBI-297852,EBI-9087684 PKP1  
  .intermediate filament bundle assembly
.single organismal cell-cell adhesion
.programmed cell death
  + 5 more...
.structural constituent of epidermis
.intermediate filament binding
.lamin binding
.signal transducer activity
.extracellular exosome
.intracellular membrane-bounded organelle
.desmosome
  + 4 more...
7 EBI-297852,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
8 EBI-297852,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
9 EBI-297852,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
10 EBI-297852,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites979
bladder33
bone97
bone marrow61
brain1
cervix123
connective tissue13
embryonic tissue122
esophagus198
eye9
heart11
intestine150
kidney23
larynx681
liver48
lung35
lymph45
lymph node11
mammary gland66
mouth75
muscle18
ovary39
pancreas89
parathyroid97
pharynx49
pituitary gland302
placenta113
prostate147
skin4
stomach83
testis9
thyroid64
uterus12
vascular19
Health State
TissuesTPM*
normal17
bladder carcinoma113
breast (mammary gland) tumor107
cervical tumor144
chondrosarcoma72
colorectal tumor239
esophageal tumor231
gastrointestinal tumor67
germ cell tumor113
glioma9
head and neck tumor7
kidney tumor72
leukemia10
liver tumor62
lung tumor87
lymphoma27
non-neoplasia20
ovarian tumor39
pancreatic tumor161
primitive neuroectodermal tumor of the CNS23
prostate cancer250
retinoblastoma21
uterine tumor22
Developmental Stage
TissuesTPM*
adult49
embryoid body142
blastocyst341
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.9
adrenal gland8.5
appendix84
cerebral cortex1.2
colon472
duodenum513.4
esophagus16.8
gallbladder137.8
heart muscle30.4
kidney68
liver159.1
lung75.3
lymph node9
ovary6.3
pancreas179.5
placenta220.2
prostate95.5
salivary gland144
skin1.1
small intestine561.5
spleen11.1
stomach375.6
testis5.4
thyroid gland140
urinary bladder78.9
Tissues
TissuesExpression level
appendixHigh
breastMedium
bronchusHigh
cervix, uterineHigh
colonMedium
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
fallopian tubeHigh
gallbladderHigh
kidneyMedium
liverHigh
lungMedium
nasopharynxHigh
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
small intestineHigh
stomach 1Medium
stomach 2High
thyroid glandMedium
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*148060, gene) Keratin 8; KRT8OMIM
2(#215600, phenotype) Cirrhosis, familialOMIM


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