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	> Protein (NX_P05787) Protein (NX_P05787) Protein Gene Symbol KRT8 to neXtProt (NX_P05787) Description Keratin, type II cytoskeletal 8 Chromosome 12 Location 12q13.13 (53290977 ~ 53343738) to Ensembl Sequene Features : Isoforms 2, Variants 59, PTMs 56 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .hepatocyte apoptotic process .extrinsic apoptotic signaling pathway .cell differentiation involved in embryonic placenta development   + 5 more... .scaffold protein binding .structural molecule activity .extracellular exosome .intermediate filament cytoskeleton .keratin filament   + 10 more... Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 2 59 56 2014-09-19 protein level 2 43 56 2014-05-27 protein level 2 43 63 2014-02-25 protein level 2 43 57 2013-12-09 protein level 2 38 57 2013-11-01 protein level 2 38 47 2013-09-12 protein level 2 38 47 2013-08-17 protein level 2 38 47 2013-07-15 protein level 2 29 47 2013-06-11 protein level 2 29 47 2013-02-12 protein level 1 19 48 2012-12-20 protein level 1 18 48 2012-10-30 protein level 1 18 48 2012-10-07 protein level 1 18 48 2012-08-24 protein level 1 15 48 2012-07-28 protein level 1 14 48 2012-06-08 protein level 1 32 48 2012-05-07 protein level 1 32 48 2012-04-10 protein level 1 32 48 2012-01-13 protein level 1 43 47 2011-12-20 protein level 1 43 47 2011-11-11 protein level 1 43 43 2011-08-23 protein level 1 45 41 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_P05787-1 0 22 4 53670.9787 NX_P05787-2 1 22 4 56573.2942 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-297852,EBI-1047263 KRT38     .N/A .structural molecule activity .extracellular exosome .intermediate filament 2 EBI-297852,EBI-297888 KRT18     .hepatocyte apoptotic process .extrinsic apoptotic signaling pathway .intermediate filament cytoskeleton organization   + 6 more... .scaffold protein binding .poly(A) RNA binding .structural molecule activity .cell periphery .extracellular exosome .perinuclear region of cytoplasm   + 6 more... 3 EBI-297852,EBI-349854 CFTR     .positive regulation of voltage-gated chloride channel activity .chloride transmembrane transport .cellular response to cAMP   + 20 more... .PDZ domain binding .enzyme binding .chloride channel inhibitor activity   + 6 more... .extracellular exosome .recycling endosome .protein complex   + 11 more... 4 EBI-297852,EBI-739566 KRT15     .activation of mitophagy in response to mitochondrial depolarization .epidermis development .scaffold protein binding .structural constituent of cytoskeleton .extracellular exosome .intermediate filament .nucleus 5 EBI-297852,EBI-401755 GRB2     .positive regulation of reactive oxygen species metabolic process .cellular response to ionizing radiation .branching involved in labyrinthine layer morphogenesis   + 25 more... .ephrin receptor binding .poly(A) RNA binding .insulin receptor substrate binding   + 6 more... .Grb2-EGFR complex .extracellular exosome .vesicle membrane   + 10 more... 6 EBI-297852,EBI-9087684 PKP1     .intermediate filament bundle assembly .single organismal cell-cell adhesion .programmed cell death   + 5 more... .structural constituent of epidermis .intermediate filament binding .lamin binding .signal transducer activity .extracellular exosome .intracellular membrane-bounded organelle .desmosome   + 4 more... 7 EBI-297852,EBI-948001 KRT31     .epidermis development .structural constituent of cytoskeleton .extracellular exosome .intermediate filament .extracellular space 8 EBI-297852,EBI-10171697 KRT40     .N/A .structural molecule activity .intermediate filament 9 EBI-297852,EBI-1105213 TFIP11     .biomineral tissue development .RNA processing .regulation of transcription, DNA-templated   + 2 more... .DNA binding .catalytic step 2 spliceosome .U2-type post-mRNA release spliceosomal complex .nuclear speck   + 3 more... 10 EBI-297852,EBI-81279 IKBKG     .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway .negative regulation of neuron death .nucleotide-binding oligomerization domain containing signaling pathway   + 35 more... .linear polyubiquitin binding .K63-linked polyubiquitin binding .protein heterodimerization activity   + 5 more... .mitotic spindle .IkappaB kinase complex .cytosol   + 5 more... EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* adipose tissue 77 ascites 979 bladder 33 bone 97 bone marrow 61 brain 1 cervix 123 connective tissue 13 embryonic tissue 122 esophagus 198 eye 9 heart 11 intestine 150 kidney 23 larynx 681 liver 48 lung 35 lymph 45 lymph node 11 mammary gland 66 mouth 75 muscle 18 ovary 39 pancreas 89 parathyroid 97 pharynx 49 pituitary gland 302 placenta 113 prostate 147 skin 4 stomach 83 testis 9 thyroid 64 uterus 12 vascular 19 Health State Tissues TPM* normal 17 bladder carcinoma 113 breast (mammary gland) tumor 107 cervical tumor 144 chondrosarcoma 72 colorectal tumor 239 esophageal tumor 231 gastrointestinal tumor 67 germ cell tumor 113 glioma 9 head and neck tumor 7 kidney tumor 72 leukemia 10 liver tumor 62 lung tumor 87 lymphoma 27 non-neoplasia 20 ovarian tumor 39 pancreatic tumor 161 primitive neuroectodermal tumor of the CNS 23 prostate cancer 250 retinoblastoma 21 uterine tumor 22 Developmental Stage Tissues TPM* adult 49 embryoid body 142 blastocyst 341 fetus 5 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 4.9 adrenal gland 8.5 appendix 84 cerebral cortex 1.2 colon 472 duodenum 513.4 esophagus 16.8 gallbladder 137.8 heart muscle 30.4 kidney 68 liver 159.1 lung 75.3 lymph node 9 ovary 6.3 pancreas 179.5 placenta 220.2 prostate 95.5 salivary gland 144 skin 1.1 small intestine 561.5 spleen 11.1 stomach 375.6 testis 5.4 thyroid gland 140 urinary bladder 78.9 Tissues Tissues Expression level appendix High breast Medium bronchus High cervix, uterine High colon Medium duodenum High endometrium 1 High endometrium 2 High epididymis High fallopian tube High gallbladder High kidney Medium liver High lung Medium nasopharynx High ovary Medium pancreas High parathyroid gland Medium placenta High prostate High rectum High salivary gland Medium seminal vesicle High small intestine High stomach 1 Medium stomach 2 High thyroid gland Medium urinary bladder High Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Expression level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected Disease No. Disease Description Ref. 1 (*148060, gene) Keratin 8; KRT8 OMIM 2 (#215600, phenotype) Cirrhosis, familial OMIM

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