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> Protein (NX_P06213)
Protein (NX_P06213)
Protein
Gene SymbolINSR to neXtProt (NX_P06213)
DescriptionInsulin receptor
Chromosome19
Location19p13.2 (7112266 ~ 7294045) to Ensembl
Sequene Features : Isoforms 2, Variants 242, PTMs 49 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to growth factor stimulus
.positive regulation of respiratory burst
.positive regulation of protein kinase B signaling
  + 31 more...
.PTB domain binding
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.extracellular exosome
.receptor complex
.intracellular membrane-bounded organelle
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 242 49
2014-09-19protein level
2 198 49
2014-05-27protein level
2 198 49
2014-02-25protein level
2 198 49
2013-12-09protein level
2 179 49
2013-11-01protein level
2 173 49
2013-09-12protein level
2 173 49
2013-08-17protein level
2 173 49
2013-07-15protein level
2 135 48
2013-06-11protein level
2 135 48
2013-02-12protein level
2 106 104
2012-12-20protein level
2 104 92
2012-10-30protein level
2 108 92
2012-10-07protein level
2 108 46
2012-08-24protein level
2 87 46
2012-07-28protein level
2 87 46
2012-06-08protein level
2 104 46
2012-05-07protein level
2 104 46
2012-04-10protein level
2 104 46
2012-01-13protein level
2 95 46
2011-12-20protein level
2 95 46
2011-11-11protein level
2 95 46
2011-08-23protein level
2 93 46
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P06213-1
2 65 4 156231.9587
NX_P06213-2
1 65 4 155045.4043
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-475899,EBI-7902275 IGF1  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of myoblast proliferation
.positive regulation of trophectodermal cell proliferation
  + 81 more...
.hormone activity
.integrin binding
.insulin-like growth factor receptor binding
.insulin receptor binding
.platelet alpha granule lumen
.insulin-like growth factor binding protein complex
.plasma membrane
  + 2 more...
2 EBI-475899,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
3 EBI-475899,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
4 EBI-475899,EBI-3197846 ENPP1  
  .nucleic acid phosphodiester bond hydrolysis
.3'-phosphoadenosine 5'-phosphosulfate metabolic process
.bone remodeling
  + 21 more...
.3'-phosphoadenosine 5'-phosphosulfate binding
.nucleoside-triphosphate diphosphatase activity
.protein homodimerization activity
  + 10 more...
.basolateral plasma membrane
.integral component of membrane
.cell surface
  + 4 more...
5 EBI-475899,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
6 EBI-475899,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
7 EBI-475899,EBI-517592 IRS1  
  .positive regulation of glucose import in response to insulin stimulus
.JAK-STAT cascade involved in growth hormone signaling pathway
.phosphatidylinositol-mediated signaling
  + 29 more...
.phosphatidylinositol 3-kinase binding
.SH2 domain binding
.insulin-like growth factor receptor binding
  + 4 more...
.intracellular membrane-bounded organelle
.ciliary basal body
.caveola
  + 5 more...
8 EBI-475899,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
9 EBI-475899,EBI-80275 GRB10  
  .insulin-like growth factor receptor signaling pathway
.negative regulation of insulin receptor signaling pathway
.negative regulation of glucose import
  + 7 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.plasma membrane
.cytosol
.cytoplasm
10 EBI-475899,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
11 EBI-475899,EBI-2361824 AGAP2  
  .negative regulation of neuron apoptotic process
.negative regulation of protein catabolic process
.protein transport
  + 2 more...
.zinc ion binding
.GTP binding
.GTPase activator activity
.extracellular exosome
.membrane
.mitochondrion
  + 2 more...
12 EBI-475899,EBI-310491 SH2B1  
  .regulation of DNA biosynthetic process
.positive regulation of mitotic nuclear division
.intracellular signal transduction
  + 2 more...
.signaling adaptor activity
.signal transducer activity
.membrane
.cytosol
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland121
ascites25
bladder33
blood16
bone27
brain17
cervix41
connective tissue6
embryonic tissue4
eye76
heart33
intestine81
kidney52
liver43
lung83
lymph node55
mammary gland66
mouth15
muscle65
ovary98
pancreas51
parathyroid97
pharynx98
placenta137
prostate36
spleen18
stomach20
testis29
thymus12
thyroid128
trachea19
uterus17
vascular19
Health State
TissuesTPM*
normal50
adrenal tumor237
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma36
colorectal tumor106
gastrointestinal tumor25
germ cell tumor18
head and neck tumor52
kidney tumor14
leukemia52
lung tumor29
non-neoplasia20
ovarian tumor52
pancreatic tumor19
primitive neuroectodermal tumor of the CNS15
prostate cancer9
uterine tumor11
Developmental Stage
TissuesTPM*
adult73
blastocyst16
fetus55
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.4
adrenal gland17.5
appendix3.4
bone marrow4.2
cerebral cortex6.7
colon13.9
duodenum10.1
esophagus4.7
gallbladder10.3
heart muscle18
kidney23.9
liver16.1
lung7.7
lymph node2.5
ovary28
pancreas23.7
placenta13.3
prostate8.7
salivary gland10.9
skin6.4
small intestine10.1
spleen26.2
stomach10.5
testis5.2
thyroid gland14.7
urinary bladder10.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#125853, phenotype) Diabetes mellitus, noninsulin-dependent; NIDDMOMIM
2(*147670, gene) Insulin receptor; INSROMIM
3(#246200, phenotype) Donohue syndromeOMIM
4(#262190, phenotype) Pineal hyperplasia, insulin-resistant diabetes mellitus, and somaticOMIM
5(#609968, phenotype) Hyperinsulinemic hypoglycemia, familial, 5; HHF5OMIM
6(#610549, phenotype) Diabetes mellitus, insulin-resistant, with acanthosis nigricansOMIM


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2014-2019 (C) Yonsei Proteome Research Center