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> Protein (NX_P06239)
Protein (NX_P06239)
Protein
Gene SymbolLCK to neXtProt (NX_P06239)
DescriptionTyrosine-protein kinase Lck
Chromosome1
Location1p35.1 (32716840 ~ 32751766) to Ensembl
Sequene Features : Isoforms 3, Variants 78, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 78 22
2014-09-19protein level
3 57 22
2014-05-27protein level
3 57 22
2014-02-25protein level
3 56 22
2013-12-09protein level
3 48 22
2013-11-01protein level
3 42 22
2013-09-12protein level
3 42 22
2013-08-17protein level
3 42 22
2013-07-15protein level
3 32 12
2013-06-11protein level
3 32 12
2013-02-12protein level
3 15 42
2012-12-20protein level
3 8 42
2012-10-30protein level
3 9 42
2012-10-07protein level
3 9 15
2012-08-24protein level
3 16 15
2012-07-28protein level
3 16 15
2012-06-08protein level
3 29 15
2012-05-07protein level
3 21 15
2012-04-10protein level
3 21 15
2012-01-13protein level
3 25 15
2011-12-20protein level
3 25 15
2011-11-11protein level
3 25 17
2011-08-23protein level
3 25 16
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P06239-1
0 23 2 57963.6857
NX_P06239-2
2 15 0 40840.3145
NX_P06239-3
2 22 2 61151.3531
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1348,EBI-1222766 LAT  
  .regulation of T cell activation
.T cell receptor signaling pathway
.positive regulation of protein kinase activity
  + 15 more...
.protein kinase binding
.SH3/SH2 adaptor activity
.membrane raft
.mast cell granule
.integral component of membrane
  + 4 more...
2 EBI-1348,EBI-353826 CD4  
  .regulation of T cell activation
.T cell receptor signaling pathway
.positive regulation of calcium-mediated signaling
  + 20 more...
.protein homodimerization activity
.MHC class II protein binding
.protein kinase binding
  + 7 more...
.membrane raft
.T cell receptor complex
.integral component of membrane
  + 5 more...
3 EBI-1348,EBI-493507 NR3C1  
  .negative regulation of glucocorticoid mediated signaling pathway
.cellular response to steroid hormone stimulus
.mammary gland duct morphogenesis
  + 14 more...
.steroid hormone binding
.glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity
.zinc ion binding
  + 5 more...
.membrane
.cytosol
.mitochondrial matrix
  + 3 more...
4 EBI-1348,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
5 EBI-1348,EBI-1341 PTPRC  
  .positive regulation of stem cell proliferation
.positive regulation of hematopoietic stem cell migration
.regulation of cell cycle
  + 24 more...
.protein kinase binding
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.membrane raft
.membrane
  + 5 more...
6 EBI-1348,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
7 EBI-1348,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
8 EBI-1348,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
9 EBI-1348,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
10 EBI-1348,EBI-958997 BCL3  
  .maintenance of protein location in nucleus
.regulation of DNA binding
.spleen development
  + 29 more...
.protein binding, bridging
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.perinuclear region of cytoplasm
.intercellular bridge
.protein complex
  + 5 more...
11 EBI-1348,EBI-78260 PTPN6  
  .regulation of G1/S transition of mitotic cell cycle
.platelet aggregation
.regulation of ERK1 and ERK2 cascade
  + 33 more...
.protein kinase binding
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.alpha-beta T cell receptor complex
.membrane
  + 5 more...
12 EBI-1348,EBI-1211276 ZAP70  
  .T cell migration
.T cell aggregation
.T cell receptor signaling pathway
  + 19 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.T cell receptor complex
.extrinsic component of cytoplasmic side of plasma membrane
.cell-cell junction
  + 4 more...
13 EBI-1348,EBI-78302 SYK  
  .regulation of platelet aggregation
.regulation of arachidonic acid secretion
.cellular response to molecule of fungal origin
  + 49 more...
.ATP binding
.integrin binding
.receptor signaling protein tyrosine kinase activity
  + 4 more...
.protein complex
.T cell receptor complex
.early phagosome
  + 6 more...
14 EBI-1348,EBI-374762 PRKCQ  
  .positive regulation of T-helper 2 cell activation
.positive regulation of T-helper 17 type immune response
.regulation of platelet aggregation
  + 26 more...
.metal ion binding
.ATP binding
.ubiquitin-protein transferase activity
  + 2 more...
.plasma membrane
.cytosol
.immunological synapse
15 EBI-1348,EBI-1364 KHDRBS1  
  .positive regulation of RNA export from nucleus
.regulation of RNA export from nucleus
.positive regulation of translational initiation
  + 8 more...
.poly(A) RNA binding
.identical protein binding
.poly(U) RNA binding
  + 4 more...
.Grb2-Sos complex
.membrane
.cytoplasm
  + 2 more...
16 EBI-1348,EBI-77818 ADAM15  
  .negative regulation of receptor binding
.protein kinase C signaling
.cardiac epithelial to mesenchymal transition
  + 11 more...
.SH3 domain binding
.zinc ion binding
.metallopeptidase activity
  + 2 more...
.extracellular exosome
.cell projection
.integral component of membrane
  + 4 more...
17 EBI-1348,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
18 EBI-1348,EBI-10194801 CDKAL1  
  .maintenance of translational fidelity .4 iron, 4 sulfur cluster binding
.metal ion binding
.N6-threonylcarbomyladenosine methylthiotransferase activity
.integral component of membrane
.membrane
.rough endoplasmic reticulum
.endoplasmic reticulum membrane
19 EBI-1348,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
20 EBI-1348,EBI-514199 MED28  
  .negative regulation of smooth muscle cell differentiation
.stem cell maintenance
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cortical actin cytoskeleton
.mediator complex
.membrane
21 EBI-1348,EBI-490630 SH2D2A  
  .vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .cytosol
.cytoplasm
22 EBI-1348,EBI-1211241 PTPN22  
  .negative regulation of T cell activation
.negative regulation of T cell receptor signaling pathway
.regulation of B cell receptor signaling pathway
  + 7 more...
.kinase binding
.SH3 domain binding
.protein tyrosine phosphatase activity
.perinuclear region of cytoplasm
.cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood376
brain8
connective tissue53
embryonic tissue23
esophagus49
heart11
intestine17
larynx298
liver14
lung11
lymph225
lymph node122
mammary gland13
mouth45
ovary9
pancreas9
prostate10
spleen524
stomach31
testis11
thymus2785
tonsil705
uterus21
vascular19
Health State
TissuesTPM*
normal41
breast (mammary gland) tumor10
colorectal tumor8
esophageal tumor57
gastrointestinal tumor25
germ cell tumor11
glioma27
head and neck tumor29
leukemia222
liver tumor10
lymphoma180
non-neoplasia82
prostate cancer9
uterine tumor33
Developmental Stage
TissuesTPM*
adult34
blastocyst16
fetus12
juvenile197
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.4
adrenal gland2.9
appendix48.8
bone marrow11.4
colon5.5
duodenum7.9
esophagus4
gallbladder10.9
heart muscle1.4
kidney2.3
liver2.1
lung11.5
lymph node110.1
ovary1.8
placenta1.1
prostate3.2
salivary gland4.2
skin1.8
small intestine10.9
spleen43.6
stomach14.1
testis1.6
thyroid gland2
urinary bladder19.4
Tissues
TissuesExpression level
appendixMedium
bone marrowMedium
lymph nodeMedium
skin 1Medium
spleenMedium
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*153390, gene) Lymphocyte-specific protein-tyrosine kinase; LCKOMIM
2T-cell acute lymphoblastic leukemiaCGP


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