Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P06241)
Protein (NX_P06241)
Protein
Gene SymbolFYN to neXtProt (NX_P06241)
DescriptionTyrosine-protein kinase Fyn
Chromosome6
Location6q21 (111981535 ~ 112194655) to Ensembl
Sequene Features : Isoforms 3, Variants 66, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 66 16
2014-09-19protein level
3 51 16
2014-05-27protein level
3 51 18
2014-02-25protein level
3 51 18
2013-12-09protein level
3 44 18
2013-11-01protein level
3 38 16
2013-09-12protein level
3 38 17
2013-08-17protein level
3 38 17
2013-07-15protein level
3 25 16
2013-06-11protein level
3 25 16
2013-02-12protein level
3 10 44
2012-12-20protein level
3 10 44
2012-10-30protein level
3 10 44
2012-10-07protein level
3 10 16
2012-08-24protein level
3 7 16
2012-07-28protein level
3 7 16
2012-06-08protein level
3 9 16
2012-05-07protein level
3 9 16
2012-04-10protein level
3 9 16
2012-01-13protein level
3 12 16
2011-12-20protein level
3 12 16
2011-11-11protein level
3 12 17
2011-08-23protein level
3 13 17
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P06241-1
2 15 7 60723.1923
NX_P06241-2
3 15 7 60102.7414
NX_P06241-3
1 15 7 54478.9484
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-515315,EBI-308663 ARHGAP32  
  .regulation of small GTPase mediated signal transduction
.small GTPase mediated signal transduction
.phosphatidylinositol binding
.GTPase activator activity
.postsynaptic membrane
.dendritic spine
.cell junction
  + 7 more...
2 EBI-515315,EBI-1210010 ARHGAP33  
  .regulation of small GTPase mediated signal transduction
.protein transport
.small GTPase mediated signal transduction
.phosphatidylinositol binding
.GTPase activator activity
.plasma membrane
.cytosol
3 EBI-515315,EBI-1753267 FYB  
  .T cell receptor signaling pathway
.intracellular signal transduction
.signal transduction
  + 3 more...
.receptor binding .actin cytoskeleton
.cytosol
.nucleus
4 EBI-515315,EBI-718488 EFS  
  .intracellular signal transduction
.cell adhesion
.protein domain specific binding .cytoplasm
5 EBI-515315,EBI-1751761 PRICKLE3  
  .N/A .zinc ion binding .N/A
6 EBI-515315,EBI-6983382 SH2D1A  
  .positive regulation of natural killer cell mediated cytotoxicity
.positive regulation of signal transduction
.cell-cell signaling
  + 2 more...
.SH3/SH2 adaptor activity .cytoplasm
7 EBI-515315,EBI-7133890 FN1  
  .leukocyte migration
.positive regulation of axon extension
.endodermal cell differentiation
  + 15 more...
.peptidase activator activity
.heparin binding
.collagen binding
  + 2 more...
.blood microparticle
.extracellular exosome
.platelet alpha granule lumen
  + 7 more...
8 EBI-515315,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
9 EBI-515315,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
10 EBI-515315,EBI-641237 PDGFRB  
  .positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
.positive regulation of calcium ion import
  + 60 more...
.platelet-derived growth factor binding
.vascular endothelial growth factor binding
.protein kinase binding
  + 7 more...
.extracellular exosome
.lysosomal lumen
.intrinsic component of plasma membrane
  + 9 more...
11 EBI-515315,EBI-1102694 ABL2  
  .negative regulation of endothelial cell apoptotic process
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 41 more...
.actin filament binding
.manganese ion binding
.ATP binding
  + 6 more...
.dendritic spine
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
  + 3 more...
12 EBI-515315,EBI-495538 FASLG  
  .positive regulation of endothelial cell apoptotic process
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 30 more...
.receptor binding .extracellular exosome
.cytoplasmic membrane-bounded vesicle lumen
.perinuclear region of cytoplasm
  + 8 more...
13 EBI-515315,EBI-1182222 HTR6  
  .long-term synaptic potentiation
.response to drug
.positive regulation of dopamine secretion
  + 10 more...
.serotonin receptor activity
.histamine receptor activity
.dendrite
.cilium
.integral component of plasma membrane
.plasma membrane
14 EBI-515315,EBI-702093 BCAR1  
  .cell chemotaxis
.cell division
.B cell receptor signaling pathway
  + 21 more...
.protein kinase binding
.signal transducer activity
.lamellipodium
.actin cytoskeleton
.focal adhesion
  + 5 more...
15 EBI-515315,EBI-374762 PRKCQ  
  .positive regulation of T-helper 2 cell activation
.positive regulation of T-helper 17 type immune response
.regulation of platelet aggregation
  + 26 more...
.metal ion binding
.ATP binding
.ubiquitin-protein transferase activity
  + 2 more...
.plasma membrane
.cytosol
.immunological synapse
16 EBI-515315,EBI-704279 PRKCD  
  .positive regulation of apoptotic signaling pathway
.positive regulation of response to DNA damage stimulus
.positive regulation of sphingomyelin catabolic process
  + 46 more...
.metal ion binding
.insulin receptor substrate binding
.enzyme binding
  + 6 more...
.extracellular exosome
.perinuclear region of cytoplasm
.nuclear matrix
  + 8 more...
17 EBI-515315,EBI-1364 KHDRBS1  
  .positive regulation of RNA export from nucleus
.regulation of RNA export from nucleus
.positive regulation of translational initiation
  + 8 more...
.poly(A) RNA binding
.identical protein binding
.poly(U) RNA binding
  + 4 more...
.Grb2-Sos complex
.membrane
.cytoplasm
  + 2 more...
18 EBI-515315,EBI-77818 ADAM15  
  .negative regulation of receptor binding
.protein kinase C signaling
.cardiac epithelial to mesenchymal transition
  + 11 more...
.SH3 domain binding
.zinc ion binding
.metallopeptidase activity
  + 2 more...
.extracellular exosome
.cell projection
.integral component of membrane
  + 4 more...
19 EBI-515315,EBI-976876 RAPGEF1  
  .negative regulation of neural precursor cell proliferation
.cellular response to nerve growth factor stimulus
.regulation of cell junction assembly
  + 17 more...
.Rap guanyl-nucleotide exchange factor activity .cytosol
.early endosome
.endosome
20 EBI-515315,EBI-310624 PDCD6IP  
  .positive regulation of extracellular exosome assembly
.regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
  + 9 more...
.calcium-dependent protein binding
.protein homodimerization activity
.proteinase activated receptor binding
.endoplasmic reticulum exit site
.extracellular exosome
.melanosome
  + 7 more...
21 EBI-515315,EBI-347721 NELFB  
  .positive regulation of viral transcription
.negative regulation of transcription, DNA-templated
.viral process
  + 3 more...
.N/A .NELF complex
.cytoplasm
.nucleoplasm
22 EBI-515315,EBI-881 MAP4K1  
  .protein autophosphorylation
.regulation of apoptotic process
.intracellular signal transduction
  + 7 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.membrane
.cytoplasm
23 EBI-515315,EBI-514199 MED28  
  .negative regulation of smooth muscle cell differentiation
.stem cell maintenance
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cortical actin cytoskeleton
.mediator complex
.membrane
24 EBI-515315,EBI-2828115 PAG1  
  .negative regulation of T cell activation
.regulation of T cell activation
.T cell receptor signaling pathway
  + 4 more...
.SH2 domain binding
.SH3/SH2 adaptor activity
.membrane raft
.integral component of membrane
.plasma membrane
25 EBI-515315,EBI-745080 NCKIPSD  
  .innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
.small GTPase mediated signal transduction
  + 3 more...
.cytoskeletal protein binding .intermediate filament
.cytosol
.nucleus
26 EBI-515315,EBI-346622 ASAP1  
  .cilium morphogenesis
.organelle organization
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.GTPase activator activity
.membrane
.cytosol
27 EBI-515315,EBI-714455 WBP11  
  .RNA splicing
.mRNA processing
.rRNA processing
.WW domain binding
.poly(A) RNA binding
.protein phosphatase type 1 regulator activity
.single-stranded DNA binding
.nuclear speck
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
blood24
bone83
brain27
cervix41
connective tissue6
ear124
embryonic tissue14
eye19
heart67
intestine17
kidney9
larynx42
liver4
lung14
lymph22
lymph node22
mammary gland33
mouth15
muscle28
nerve64
ovary39
pancreas9
pharynx122
pituitary gland60
placenta10
skin94
spleen56
stomach73
testis11
thymus37
thyroid322
uterus43
vascular38
Health State
TissuesTPM*
normal54
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma48
colorectal tumor17
gastrointestinal tumor8
germ cell tumor15
glioma111
head and neck tumor112
kidney tumor43
leukemia31
liver tumor31
lung tumor9
lymphoma27
non-neoplasia62
pancreatic tumor38
primitive neuroectodermal tumor of the CNS47
skin tumor47
soft tissue/muscle tissue tumor23
uterine tumor66
Developmental Stage
TissuesTPM*
adult8
embryoid body14
blastocyst16
fetus39
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue72
adrenal gland17.1
appendix82.8
bone marrow28.5
cerebral cortex132.6
colon27.9
duodenum28.3
esophagus21.9
gallbladder58.3
heart muscle40.4
kidney35.5
liver38.1
lung54.6
lymph node169.9
ovary40.2
pancreas7.1
placenta37.4
prostate15.5
salivary gland12.1
skin25.1
small intestine37
spleen93.5
stomach41.2
testis30.7
thyroid gland77.7
urinary bladder54.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
cerebral cortexMedium
colonLow
epididymisLow
fallopian tubeMedium
gallbladderLow
kidneyLow
liverMedium
lymph nodeHigh
seminal vesicleLow
skin 1Low
soft tissue 1Low
soft tissue 2Low
spleenLow
thyroid glandMedium
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*137025, gene) Fyn oncogene related to src, fgr, yes; FYNOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center