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> Protein (NX_P06396)
Protein (NX_P06396)
Protein
Gene SymbolGSN to neXtProt (NX_P06396)
DescriptionGelsolin
Chromosome9
Location9q33.2 (123970072 ~ 124095121) to Ensembl
Sequene Features : Isoforms 4, Variants 96, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.amyloid fibril formation
.positive regulation of protein processing in phagocytic vesicle
  + 32 more...
.myosin II binding
.protein domain specific binding
.calcium ion binding
.actin binding
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 96 10
2014-09-19protein level
4 71 10
2014-05-27protein level
4 71 10
2014-02-25protein level
3 71 9
2013-12-09protein level
3 59 9
2013-11-01protein level
3 59 8
2013-09-12protein level
3 59 8
2013-08-17protein level
3 59 8
2013-07-15protein level
3 50 6
2013-06-11protein level
3 50 6
2013-02-12protein level
3 35 16
2012-12-20protein level
3 35 16
2012-10-30protein level
3 37 16
2012-10-07protein level
3 37 6
2012-08-24protein level
3 35 6
2012-07-28protein level
3 35 6
2012-06-08protein level
3 35 6
2012-05-07protein level
3 34 6
2012-04-10protein level
3 34 6
2012-01-13protein level
2 17 6
2011-12-20protein level
2 17 6
2011-11-11protein level
2 17 6
2011-08-23protein level
2 17 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P06396-1
3 27 0 85643.9459
NX_P06396-2
1 27 0 80590.2858
NX_P06396-3
1 27 0 81889.8276
NX_P06396-4
1 27 0 81433.6455
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-351506,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
2 EBI-351506,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue3653
adrenal gland151
ascites778
bladder66
blood327
bone209
bone marrow389
brain480
cervix123
connective tissue362
ear186
embryonic tissue70
esophagus446
eye440
heart703
intestine581
kidney488
larynx255
liver73
lung200
lymph node144
mammary gland330
mouth1209
muscle253
nerve643
ovary187
pancreas477
parathyroid485
pharynx220
pituitary gland242
placenta166
prostate269
salivary gland98
skin768
spleen655
stomach668
testis151
thymus188
thyroid558
tonsil58
trachea521
umbilical cord363
uterus435
vascular406
Health State
TissuesTPM*
normal387
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor311
cervical tumor28
chondrosarcoma181
colorectal tumor435
esophageal tumor463
gastrointestinal tumor531
germ cell tumor163
glioma279
head and neck tumor597
kidney tumor624
leukemia730
liver tumor72
lung tumor116
non-neoplasia517
ovarian tumor105
pancreatic tumor752
primitive neuroectodermal tumor of the CNS7
prostate cancer86
skin tumor949
soft tissue/muscle tissue tumor63
uterine tumor310
Developmental Stage
TissuesTPM*
adult318
embryoid body85
blastocyst65
neonate772
fetus184
infant42
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue776.7
adrenal gland165.3
appendix109.5
bone marrow108.5
cerebral cortex107.3
colon277.9
duodenum123.2
esophagus446.2
gallbladder256.3
heart muscle656
kidney88.3
liver49
lung208.2
lymph node90.7
ovary194.6
pancreas68.4
placenta95.8
prostate245
salivary gland208.9
skin234.8
small intestine161.4
spleen97.9
stomach229.5
testis103.3
thyroid gland197.6
urinary bladder283.7
Tissues
TissuesExpression level
adrenal glandLow
bone marrowMedium
breastLow
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumLow
endometrium 1High
endometrium 2Medium
fallopian tubeLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
ovaryLow
pancreasMedium
placentaLow
salivary glandMedium
skin 1Low
skin 2Medium
smooth muscleLow
soft tissue 1Low
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
tonsilLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#105120, phenotype) Amyloidosis, finnish typeOMIM
2(*137350, gene) Gelsolin; GSNOMIM


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