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> Protein (NX_P06400)
Protein (NX_P06400)
Protein
Gene SymbolRB1 to neXtProt (NX_P06400)
DescriptionRetinoblastoma-associated protein
Chromosome13
Location13q14.2 (48877887 ~ 49056122) to Ensembl
Sequene Features : Isoforms 1, Variants 225, PTMs 30 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of G1/S transition of mitotic cell cycle
.hepatocyte apoptotic process
.regulation of centromere complex assembly
  + 39 more...
.phosphoprotein binding
.androgen receptor binding
.identical protein binding
  + 7 more...
.Rb-E2F complex
.PML body
.SWI/SNF complex
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 225 30
2014-09-19protein level
1 201 30
2014-05-27protein level
1 201 30
2014-02-25protein level
1 203 30
2013-12-09protein level
1 193 30
2013-11-01protein level
1 193 30
2013-09-12protein level
1 193 30
2013-08-17protein level
1 193 30
2013-07-15protein level
1 104 24
2013-06-11protein level
1 104 24
2013-02-12protein level
1 78 22
2012-12-20protein level
1 78 21
2012-10-30protein level
1 81 21
2012-10-07protein level
1 81 21
2012-08-24protein level
1 79 21
2012-07-28protein level
1 79 21
2012-06-08protein level
1 48 21
2012-05-07protein level
1 48 21
2012-04-10protein level
1 48 21
2012-01-13protein level
1 42 21
2011-12-20protein level
1 42 21
2011-11-11protein level
1 42 26
2011-08-23protein level
1 42 23
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P06400-1
37 0 0 106091.405
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-491274,EBI-765551 E2F3  
  .negative regulation of fat cell proliferation
.positive regulation of transcription, DNA-templated
.positive regulation of cell proliferation
  + 3 more...
.sequence-specific DNA binding transcription factor activity
.core promoter binding
.intracellular membrane-bounded organelle
.Golgi apparatus
.cytoplasm
  + 3 more...
2 EBI-491274,EBI-974488 CHEK1  
  .regulation of histone H3-K9 acetylation
.negative regulation of DNA biosynthetic process
.replicative senescence
  + 17 more...
.histone kinase activity (H3-T11 specific)
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.intracellular membrane-bounded organelle
.cytosol
.centrosome
  + 6 more...
3 EBI-491274,EBI-398437 MDM4  
  .cellular response to hypoxia
.negative regulation of cell cycle arrest
.protein stabilization
  + 9 more...
.enzyme binding
.zinc ion binding
.nucleoplasm
.nucleus
4 EBI-491274,EBI-954175 HBP1  
  .positive regulation of potassium ion transport
.Wnt signaling pathway
.cell cycle arrest
  + 2 more...
.RNA binding
.DNA binding
.nucleoplasm
5 EBI-491274,EBI-744408 RNF40  
  .positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.histone H2B ubiquitination
  + 2 more...
.protein homodimerization activity
.ubiquitin protein ligase binding
.ligase activity
  + 3 more...
.neuron projection
.HULC complex
.membrane
  + 3 more...
6 EBI-491274,EBI-1180783 CHEK2  
  .replicative senescence
.mitotic spindle assembly
.signal transduction involved in intra-S DNA damage checkpoint
  + 18 more...
.metal ion binding
.protein homodimerization activity
.identical protein binding
  + 4 more...
.PML body
.Golgi apparatus
.nucleoplasm
7 EBI-491274,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
8 EBI-491274,EBI-1105035 NEFM  
  .activation of mitophagy in response to mitochondrial depolarization
.neurofilament bundle assembly
.regulation of axon diameter
  + 2 more...
.microtubule binding
.structural constituent of cytoskeleton
.neurofibrillary tangle
.neuromuscular junction
.axon
.neurofilament
9 EBI-491274,EBI-375096 CDK2  
  .cellular response to nitric oxide
.regulation of gene silencing
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 20 more...
.metal ion binding
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.Cajal body
.cytosol
.centrosome
  + 10 more...
10 EBI-491274,EBI-1383583 FRK  
  .innate immune response
.regulation of cell proliferation
.peptidyl-tyrosine autophosphorylation
  + 6 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
  + 2 more...
11 EBI-491274,EBI-78458 PRMT2  
  .negative regulation of G1/S transition of mitotic cell cycle
.regulation of androgen receptor signaling pathway
.developmental cell growth
  + 9 more...
.androgen receptor binding
.thyroid hormone receptor binding
.peroxisome proliferator activated receptor binding
  + 10 more...
.cytosol
.cytoplasm
.nucleolus
  + 2 more...
12 EBI-491274,EBI-357253 PPP1CA  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.cell division
.branching morphogenesis of an epithelial tube
  + 15 more...
.metal ion binding
.ribonucleoprotein complex binding
.phosphatase activity
.protein serine/threonine phosphatase activity
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 10 more...
13 EBI-491274,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
14 EBI-491274,EBI-1045860 PURA  
  .negative regulation of transcription, DNA-templated
.cell differentiation
.positive regulation of cell proliferation
  + 5 more...
.poly(A) RNA binding
.purine-rich negative regulatory element binding
.transcription factor binding
  + 4 more...
.neuronal cell body
.dendrite
.cytoplasm
  + 3 more...
15 EBI-491274,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
16 EBI-491274,EBI-448924 E2F1  
  .regulation of G1/S transition of mitotic cell cycle
.lens fiber cell apoptotic process
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.Rb-E2F complex
.cytoplasm
.nucleoplasm
.nucleus
17 EBI-491274,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
18 EBI-491274,EBI-715527 DGKZ  
  .lipid phosphorylation
.negative regulation of Ras protein signal transduction
.negative regulation of mitotic cell cycle
  + 7 more...
.metal ion binding
.protein C-terminus binding
.ATP binding
  + 4 more...
.lamellipodium
.plasma membrane
.cytoplasm
  + 2 more...
19 EBI-491274,EBI-1053596 DYRK1A  
  .positive regulation of protein deacetylation
.protein autophosphorylation
.negative regulation of DNA damage response, signal transduction by p53 class mediator
  + 8 more...
.tau protein binding
.protein self-association
.ATP binding
  + 5 more...
.ribonucleoprotein complex
.nuclear speck
.nucleoplasm
.nucleus
20 EBI-491274,EBI-718476 E2F2  
  .lens fiber cell apoptotic process
.intrinsic apoptotic signaling pathway by p53 class mediator
.regulation of cell cycle
  + 2 more...
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.core promoter binding
.transcription factor complex
.nucleoplasm
21 EBI-491274,EBI-2650369 IRF3  
  .programmed necrotic cell death
.macrophage apoptotic process
.cellular response to dsRNA
  + 28 more...
.transcription regulatory region DNA binding
.protein homodimerization activity
.identical protein binding
  + 3 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
22 EBI-491274,EBI-78670 NCOA6  
  .labyrinthine layer blood vessel development
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 14 more...
.thyroid hormone receptor binding
.retinoid X receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 4 more...
.intracellular membrane-bounded organelle
.histone methyltransferase complex
.transcription factor complex
  + 2 more...
23 EBI-491274,EBI-73946 MAPK14  
  .positive regulation of reactive oxygen species metabolic process
.positive regulation of myoblast fusion
.regulation of cytokine production involved in inflammatory response
  + 64 more...
.NFAT protein binding
.ATP binding
.MAP kinase kinase activity
  + 2 more...
.extracellular exosome
.cytosol
.mitochondrion
  + 4 more...
24 EBI-491274,EBI-1268586 SETD7  
  .heterochromatin organization
.peptidyl-lysine dimethylation
.peptidyl-lysine monomethylation
  + 5 more...
.histone-lysine N-methyltransferase activity
.protein-lysine N-methyltransferase activity
.p53 binding
.nucleolus
.chromosome
.nucleoplasm
25 EBI-491274,EBI-302474 USP7  
  .regulation of proteasomal protein catabolic process
.regulation of sequence-specific DNA binding transcription factor activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 7 more...
.ubiquitin protein ligase binding
.transcription factor binding
.protein C-terminus binding
  + 3 more...
.PML body
.nuclear body
.cytosol
.nucleus
26 EBI-491274,EBI-625304 UHRF2  
  .regulation of methylation-dependent chromatin silencing
.positive regulation of cell cycle arrest
.protein autoubiquitination
  + 7 more...
.ubiquitin protein ligase activity
.histone binding
.ligase activity
  + 3 more...
.nuclear heterochromatin
.nucleoplasm
.nucleus
27 EBI-491274,EBI-924893 PA2G4  
  .negative regulation of transcription, DNA-templated
.positive regulation of cell differentiation
.negative regulation of apoptotic process
  + 5 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.extracellular exosome
.ribonucleoprotein complex
.membrane
  + 4 more...
28 EBI-491274,EBI-634187 DYRK1B  
  .adipose tissue development
.positive regulation of transcription, DNA-templated
.myoblast fusion
.protein phosphorylation
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
  + 3 more...
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bladder100
blood57
bone27
bone marrow41
brain36
cervix20
connective tissue13
embryonic tissue42
eye38
intestine25
kidney42
larynx213
liver29
lung8
lymph22
lymph node211
mammary gland66
mouth75
muscle47
ovary29
pancreas46
pharynx24
placenta81
prostate31
salivary gland49
skin56
spleen18
stomach10
testis73
thymus87
thyroid107
trachea115
uterus73
Health State
TissuesTPM*
normal45
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma24
colorectal tumor26
germ cell tumor60
glioma74
head and neck tumor112
kidney tumor72
leukemia21
liver tumor31
lung tumor9
lymphoma41
non-neoplasia103
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer48
retinoblastoma21
skin tumor55
soft tissue/muscle tissue tumor15
uterine tumor77
Developmental Stage
TissuesTPM*
adult50
embryoid body28
blastocyst65
neonate96
fetus35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.9
adrenal gland25.9
appendix31.4
bone marrow10.3
cerebral cortex21.4
colon22.2
duodenum18.7
esophagus28.3
gallbladder30.7
heart muscle16.5
kidney18
liver10.1
lung20.1
lymph node37.6
ovary14.2
pancreas5.4
placenta28.3
prostate17.1
salivary gland14.7
skin9.8
small intestine21.8
spleen30.5
stomach19.2
testis17.1
thyroid gland27.8
urinary bladder35.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverHigh
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryLow
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenHigh
stomach 1Medium
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#109800, phenotype) Bladder cancerOMIM
2(#180200, phenotype) Retinoblastoma; RB1OMIM
3(#259500, phenotype) Osteogenic sarcomaOMIM
4(*614041, gene) Rb1 gene; RB1OMIM
5retinoblastoma;sarcoma;breast;small cell lung;Familial retinoblastomaCGP


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