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> Protein (NX_P06493)
Protein (NX_P06493)
Protein
Gene SymbolCDK1 to neXtProt (NX_P06493)
DescriptionCyclin-dependent kinase 1
Chromosome10
Location10q21.2 (62538089 ~ 62554610) to Ensembl
Sequene Features : Isoforms 2, Variants 27, PTMs 32 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to hydrogen peroxide
.positive regulation of cardiac muscle cell proliferation
.ventricular cardiac muscle cell development
  + 69 more...
.histone kinase activity
.RNA polymerase II carboxy-terminal domain kinase activity
.ATP binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.midbody
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 27 32
2014-09-19protein level
2 21 32
2014-05-27protein level
2 21 32
2014-02-25protein level
2 21 30
2013-12-09protein level
2 20 30
2013-11-01protein level
2 19 28
2013-09-12protein level
2 19 28
2013-08-17protein level
2 19 28
2013-07-15protein level
2 11 14
2013-06-11protein level
2 11 14
2013-02-12protein level
2 5 36
2012-12-20protein level
2 5 36
2012-10-30protein level
2 4 36
2012-10-07protein level
2 4 20
2012-08-24protein level
2 4 20
2012-07-28protein level
2 4 20
2012-06-08protein level
2 6 20
2012-05-07protein level
2 5 20
2012-04-10protein level
2 5 20
2012-01-13protein level
2 9 20
2011-12-20protein level
2 9 20
2011-11-11protein level
2 9 21
2011-08-23protein level
2 7 18
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P06493-1
3 13 2 34073.7861
NX_P06493-2
0 13 1 27485.2206
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-444308,EBI-444209 LATS1  
  .negative regulation of canonical Wnt signaling pathway
.cell division
.cytoplasmic sequestering of protein
  + 11 more...
.protein kinase binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytosol
.microtubule organizing center
.spindle pole
2 EBI-444308,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
3 EBI-444308,EBI-495332 CCNB1  
  .histone H3-S10 phosphorylation involved in chromosome condensation
.regulation of mitotic cell cycle spindle assembly checkpoint
.cellular response to hypoxia
  + 33 more...
.histone kinase activity
.protein kinase binding
.patched binding
.membrane
.cytosol
.centrosome
  + 5 more...
4 EBI-444308,EBI-640775 EIF2AK2  
  .regulation of hematopoietic stem cell differentiation
.regulation of hematopoietic stem cell proliferation
.regulation of hematopoietic progenitor cell differentiation
  + 27 more...
.poly(A) RNA binding
.protein phosphatase type 2A regulator activity
.ATP binding
  + 5 more...
.perinuclear region of cytoplasm
.membrane
.ribosome
  + 3 more...
5 EBI-444308,EBI-974439 CDC25C  
  .regulation of cell cycle
.cell division
.peptidyl-tyrosine dephosphorylation
  + 10 more...
.WW domain binding
.protein kinase binding
.protein tyrosine phosphatase activity
.perinuclear region of cytoplasm
.cytosol
.nucleoplasm
.nucleus
6 EBI-444308,EBI-456371 CKS1B  
  .cell division
.cell proliferation
.mitotic cell cycle
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .nucleoplasm
7 EBI-444308,EBI-1108782 FOXO1  
  .regulation of energy homeostasis
.regulation of reactive oxygen species metabolic process
.regulation of neural precursor cell proliferation
  + 38 more...
.protein phosphatase 2A binding
.sequence-specific DNA binding
.ubiquitin protein ligase binding
  + 4 more...
.cytosol
.mitochondrion
.cytoplasm
  + 2 more...
8 EBI-444308,EBI-495308 PKMYT1  
  .regulation of cell cycle
.negative regulation of phosphatase activity
.regulation of mitotic nuclear division
  + 5 more...
.metal ion binding
.kinase activity
.ATP binding
  + 2 more...
.membrane
.cytosol
.Golgi apparatus
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
bladder100
blood40
bone41
bone marrow61
brain8
cervix20
connective tissue40
embryonic tissue93
esophagus148
eye19
heart33
intestine43
kidney33
liver48
lung32
lymph22
lymph node367
mammary gland145
mouth30
muscle47
ovary29
pancreas9
pharynx24
pituitary gland60
placenta14
prostate10
salivary gland98
skin28
stomach20
testis59
thymus75
tonsil58
umbilical cord72
uterus60
vascular38
Health State
TissuesTPM*
normal37
adrenal tumor158
breast (mammary gland) tumor214
chondrosarcoma60
colorectal tumor53
esophageal tumor115
gastrointestinal tumor50
germ cell tumor75
glioma18
head and neck tumor7
kidney tumor58
leukemia74
liver tumor52
lung tumor58
lymphoma13
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS78
prostate cancer19
retinoblastoma64
skin tumor31
soft tissue/muscle tissue tumor199
uterine tumor22
Developmental Stage
TissuesTPM*
adult37
embryoid body128
blastocyst81
neonate96
fetus37
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.8
adrenal gland2.1
appendix22.5
bone marrow46.2
cerebral cortex2.5
colon19.5
duodenum18.1
esophagus15.2
gallbladder5.3
heart muscle1.1
kidney2.9
liver2.1
lung4.9
lymph node44.9
ovary2.8
placenta21.4
prostate1.7
salivary gland1.5
skin15.1
small intestine17.2
spleen8.9
stomach11.5
testis23.8
thyroid gland3.3
urinary bladder12
Tissues
TissuesExpression level
appendixMedium
bone marrowMedium
breastMedium
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
kidneyMedium
lungLow
lymph nodeHigh
oral mucosaMedium
ovaryLow
pancreasLow
parathyroid glandLow
placentaMedium
prostateMedium
rectumMedium
skin 1Low
skin 2Medium
small intestineMedium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*116940, gene) Cyclin-dependent kinase 1; CDK1OMIM


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