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> Protein (NX_P06730)
Protein (NX_P06730)
Protein
Gene SymbolEIF4E to neXtProt (NX_P06730)
DescriptionEukaryotic translation initiation factor 4E
Chromosome4
Location4q23 (99792835 ~ 99851788) to Ensembl
Sequene Features : Isoforms 3, Variants 14, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of mitotic cell cycle
.cellular protein metabolic process
.lung development
  + 11 more...
.poly(A) RNA binding
.translation initiation factor activity
.RNA cap binding
.extracellular exosome
.chromatoid body
.RISC complex
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 14 5
2014-09-19protein level
3 10 5
2014-05-27protein level
3 10 5
2014-02-25protein level
3 9 5
2013-12-09protein level
3 9 5
2013-11-01protein level
3 9 3
2013-09-12protein level
3 9 3
2013-08-17protein level
3 9 3
2013-07-15protein level
3 9 1
2013-06-11protein level
3 9 1
2013-02-12protein level
3 3 5
2012-12-20protein level
3 3 5
2012-10-30protein level
3 3 5
2012-10-07protein level
3 3 2
2012-08-24protein level
3 1 2
2012-07-28protein level
3 1 2
2012-06-08protein level
3 8 2
2012-05-07protein level
3 8 2
2012-04-10protein level
2 8 2
2012-01-13protein level
2 9 2
2011-12-20protein level
2 9 2
2011-11-11protein level
2 9 2
2011-08-23protein level
1 9 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P06730-1
0 8 0 25081.4413
NX_P06730-2
3 7 0 28759.4942
NX_P06730-3
1 7 0 27242.4982
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-73440,EBI-746950 EIF4EBP3  
  .negative regulation of translational initiation .translation repressor activity
.eukaryotic initiation factor 4E binding
.eukaryotic translation initiation factor 4F complex
.membrane
.cytoplasm
2 EBI-73440,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-73440,EBI-1050853 LRPPRC  
  .regulation of mitochondrial translation
.mRNA transport
.mitochondrion transport along microtubule
  + 3 more...
.beta-tubulin binding
.poly(A) RNA binding
.ubiquitin protein ligase binding
  + 3 more...
.perinuclear region of cytoplasm
.mitochondrial nucleoid
.ribonucleoprotein complex
  + 9 more...
4 EBI-73440,EBI-743494 TDO2  
  .small molecule metabolic process
.cellular nitrogen compound metabolic process
.tryptophan catabolic process to acetyl-CoA
  + 2 more...
.metal ion binding
.heme binding
.oxygen binding
  + 2 more...
.cytosol
5 EBI-73440,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
6 EBI-73440,EBI-73711 EIF4G1  
  .cellular protein metabolic process
.cytokine-mediated signaling pathway
.viral process
  + 8 more...
.poly(A) RNA binding
.translation factor activity, RNA binding
.translation initiation factor activity
.eukaryotic translation initiation factor 4F complex
.membrane
.cytosol
7 EBI-73440,EBI-399831 EMX2  
  .renal system development
.response to drug
.neuron differentiation
  + 6 more...
.sequence-specific DNA binding .nucleus
8 EBI-73440,EBI-74090 EIF4EBP1  
  .negative regulation of translational initiation
.positive regulation of mitotic cell cycle
.response to ethanol
  + 11 more...
.translation repressor activity
.eukaryotic initiation factor 4E binding
.protein complex
.cytosol
.cytoplasm
.nucleoplasm
9 EBI-73440,EBI-935137 EIF4EBP2  
  .regulation of synaptic transmission
.regulation of synaptic plasticity
.negative regulation of translational initiation
  + 6 more...
.translation repressor activity
.eukaryotic initiation factor 4E binding
.cytoplasm
10 EBI-73440,EBI-746004 UBXN11  
  .proteasome-mediated ubiquitin-dependent protein catabolic process .ubiquitin binding .cytoskeleton
.cytoplasm
11 EBI-73440,EBI-2556193 KANK2  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of vitamin D receptor signaling pathway
.negative regulation of programmed cell death
  + 5 more...
.N/A .mitochondrion
.cytoplasm
12 EBI-73440,EBI-443630 GEMIN5  
  .ncRNA metabolic process
.gene expression
.protein complex assembly
  + 2 more...
.poly(A) RNA binding
.snRNA binding
.Gemini of coiled bodies
.SMN-Sm protein complex
.SMN complex
  + 6 more...
13 EBI-73440,EBI-301024 EIF4ENIF1  
  .N/A .poly(A) RNA binding
.protein transporter activity
.intracellular membrane-bounded organelle
.nuclear speck
.PML body
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites476
bladder502
blood114
bone83
bone marrow820
brain172
cervix206
connective tissue87
ear124
embryonic tissue112
esophagus198
eye71
heart89
intestine99
kidney151
liver97
lung95
lymph22
lymph node122
mammary gland85
mouth90
muscle94
nerve64
ovary59
pancreas46
parathyroid48
pharynx245
pituitary gland121
placenta45
prostate116
salivary gland246
skin33
spleen93
stomach94
testis218
thymus12
thyroid42
trachea96
umbilical cord145
uterus133
vascular271
Health State
TissuesTPM*
normal117
adrenal tumor79
bladder carcinoma739
breast (mammary gland) tumor32
cervical tumor115
chondrosarcoma96
colorectal tumor88
esophageal tumor173
gastrointestinal tumor227
germ cell tumor174
glioma83
head and neck tumor37
kidney tumor130
leukemia455
liver tumor93
lung tumor38
lymphoma124
non-neoplasia144
ovarian tumor52
pancreatic tumor57
primitive neuroectodermal tumor of the CNS173
prostate cancer125
retinoblastoma129
skin tumor15
soft tissue/muscle tissue tumor151
uterine tumor110
Developmental Stage
TissuesTPM*
adult99
embryoid body100
blastocyst32
neonate193
fetus116
infant467
juvenile287
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.6
adrenal gland9.6
appendix9.3
bone marrow12.1
cerebral cortex7.9
colon10.1
duodenum7.5
esophagus7.3
gallbladder5.5
heart muscle5
kidney9.2
liver6.1
lung7.1
lymph node8.8
ovary4.9
pancreas2.3
placenta6.9
prostate7.1
salivary gland4.9
skin5
small intestine8.5
spleen7.3
stomach8.7
testis9.8
thyroid gland8
urinary bladder6.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleLow
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*133440, gene) Eukaryotic translation initiation factor 4e; EIF4EOMIM


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