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> Protein (NX_P07237)
Protein (NX_P07237)
Protein
Gene SymbolP4HB to neXtProt (NX_P07237)
DescriptionProtein disulfide-isomerase
Chromosome17
Location17q25.3 (79801035 ~ 79818570) to Ensembl
Sequene Features : Isoforms 1, Variants 60, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.cellular response to hypoxia
.cell redox homeostasis
  + 8 more...
.poly(A) RNA binding
.procollagen-proline 4-dioxygenase activity
.endopeptidase activity
.protein disulfide isomerase activity
.extracellular exosome
.melanosome
.procollagen-proline 4-dioxygenase complex
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 60 15
2014-09-19protein level
1 44 15
2014-05-27protein level
1 44 15
2014-02-25protein level
1 44 12
2013-12-09protein level
1 30 12
2013-11-01protein level
1 28 6
2013-09-12protein level
1 28 6
2013-08-17protein level
1 28 6
2013-07-15protein level
1 24 4
2013-06-11protein level
1 24 4
2013-02-12protein level
1 9 2
2012-12-20protein level
1 9 2
2012-10-30protein level
1 9 2
2012-10-07protein level
1 9 2
2012-08-24protein level
1 8 2
2012-07-28protein level
1 8 2
2012-06-08protein level
1 20 2
2012-05-07protein level
1 20 2
2012-04-10protein level
1 20 2
2012-01-13protein level
1 15 2
2011-12-20protein level
1 15 2
2011-11-11protein level
1 15 2
2011-08-23protein level
1 15 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P07237-1
30 0 0 57080.5141
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-395883,EBI-747259 TAP1  
  .transmembrane transport
.cytosol to ER transport
.antigen processing and presentation of exogenous peptide antigen via MHC class I
  + 6 more...
.TAP2 binding
.TAP1 binding
.ADP binding
  + 7 more...
.TAP complex
.integral component of endoplasmic reticulum membrane
.integral component of membrane
  + 3 more...
2 EBI-395883,EBI-2211957 PRDX4  
  .negative regulation of male germ cell proliferation
.reactive oxygen species metabolic process
.cell redox homeostasis
  + 6 more...
.thioredoxin peroxidase activity .extracellular exosome
.cytosol
.smooth endoplasmic reticulum
  + 3 more...
3 EBI-395883,EBI-347472 HM13  
  .membrane protein proteolysis .protein homodimerization activity
.aspartic endopeptidase activity, intramembrane cleaving
.ubiquitin protein ligase binding
.peptidase activity
.integral component of lumenal side of endoplasmic reticulum membrane
.integral component of cytoplasmic side of endoplasmic reticulum membrane
.membrane
  + 4 more...
4 EBI-395883,EBI-2564539 ERO1L  
  .intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.release of sequestered calcium ion into cytosol
.chaperone mediated protein folding requiring cofactor
  + 12 more...
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.oxidoreductase activity
.protein disulfide oxidoreductase activity
.protein disulfide isomerase activity
.intracellular membrane-bounded organelle
.membrane
.endoplasmic reticulum membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue544
adrenal gland1973
ascites828
bladder1473
blood613
bone516
bone marrow820
brain746
cervix598
connective tissue1509
ear62
embryonic tissue479
esophagus1835
eye407
heart636
intestine978
kidney1575
larynx213
liver964
lung707
lymph564
lymph node111
mammary gland1262
mouth1965
muscle423
nerve708
ovary561
pancreas791
parathyroid48
pharynx220
pituitary gland302
placenta922
prostate1435
salivary gland1529
skin1788
spleen3239
stomach1546
testis415
thymus815
thyroid1588
tonsil411
trachea2665
umbilical cord1307
uterus771
vascular3949
Health State
TissuesTPM*
adrenal tumor1027
bladder carcinoma796
breast (mammary gland) tumor1697
cervical tumor666
chondrosarcoma603
colorectal tumor933
esophageal tumor2029
gastrointestinal tumor1400
germ cell tumor1143
glioma1763
head and neck tumor1337
kidney tumor1147
leukemia709
liver tumor1385
lung tumor1031
lymphoma512
non-neoplasia1200
ovarian tumor459
pancreatic tumor1257
primitive neuroectodermal tumor of the CNS1275
prostate cancer1290
retinoblastoma796
skin tumor973
soft tissue/muscle tissue tumor399
uterine tumor854
Developmental Stage
TissuesTPM*
adult724
embryoid body714
blastocyst309
neonate4538
fetus342
infant552
juvenile2393
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue223.3
adrenal gland238.8
appendix258.4
bone marrow561.8
cerebral cortex86.5
colon286
duodenum539.9
esophagus314.1
gallbladder252.6
heart muscle170.2
kidney159.1
liver644.4
lung214.2
lymph node132.5
ovary138.6
pancreas931.3
placenta396.6
prostate327.2
salivary gland674.8
skin244.4
small intestine492.5
spleen284.2
stomach384.1
testis76.8
thyroid gland290.8
urinary bladder229
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyHigh
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skin 1Medium
skin 2Medium
small intestineHigh
soft tissue 1Low
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176790, gene) Procollagen-proline, 2-oxoglutarate-4-dioxygenase, beta subunit; P4HBOMIM


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