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> Protein (NX_P07332)
Protein (NX_P07332)
Protein
Gene SymbolFES to neXtProt (NX_P07332)
DescriptionTyrosine-protein kinase Fes/Fps
Chromosome15
Location15q26.1 (91426925 ~ 91439006) to Ensembl
Sequene Features : Isoforms 4, Variants 98, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of actin cytoskeleton reorganization
.regulation of cell motility
.regulation of vesicle-mediated transport
  + 19 more...
.phosphatidylinositol binding
.immunoglobulin receptor binding
.ATP binding
  + 2 more...
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic membrane-bounded vesicle
.microtubule cytoskeleton
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 98 7
2014-09-19protein level
4 71 7
2014-05-27protein level
4 71 7
2014-02-25protein level
4 71 7
2013-12-09protein level
4 54 7
2013-11-01protein level
4 51 6
2013-09-12protein level
4 51 6
2013-08-17protein level
4 51 6
2013-07-15protein level
4 33 6
2013-06-11protein level
4 33 6
2013-02-12protein level
4 18 52
2012-12-20protein level
4 20 52
2012-10-30protein level
4 24 52
2012-10-07protein level
4 24 13
2012-08-24protein level
4 23 13
2012-07-28protein level
4 23 13
2012-06-08protein level
4 36 13
2012-05-07protein level
4 33 13
2012-04-10protein level
4 33 13
2012-01-13protein level
4 24 13
2011-12-20protein level
4 24 13
2011-11-11protein level
4 24 13
2011-08-23protein level
1 12 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P07332-1
0 37 2 93437.9412
NX_P07332-2
0 30 2 78583.0938
NX_P07332-3
0 34 2 86608.3598
NX_P07332-4
0 33 2 85412.6752
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1055635,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
2 EBI-1055635,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
3 EBI-1055635,EBI-1056902 EZR  
  .establishment of endothelial barrier
.actin filament bundle assembly
.positive regulation of protein secretion
  + 13 more...
.actin filament binding
.cell adhesion molecule binding
.poly(A) RNA binding
.cytoplasmic side of apical plasma membrane
.Schwann cell microvillus
.astrocyte projection
  + 30 more...
4 EBI-1055635,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
bladder66
blood73
bone13
bone marrow20
brain10
cervix20
connective tissue67
embryonic tissue14
esophagus49
eye28
intestine17
kidney23
liver9
lung20
lymph node66
mammary gland13
mouth60
muscle28
nerve64
ovary19
pancreas4
placenta77
prostate21
salivary gland49
skin42
spleen543
stomach31
testis6
thymus125
thyroid64
trachea193
umbilical cord145
uterus21
vascular154
Health State
TissuesTPM*
normal36
cervical tumor28
chondrosarcoma60
colorectal tumor17
esophageal tumor57
gastrointestinal tumor8
germ cell tumor3
glioma18
head and neck tumor14
kidney tumor14
leukemia148
liver tumor10
lung tumor9
non-neoplasia62
ovarian tumor13
pancreatic tumor9
skin tumor63
uterine tumor11
Developmental Stage
TissuesTPM*
adult29
embryoid body14
neonate64
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.9
adrenal gland7.8
appendix28.5
bone marrow53.4
cerebral cortex3
colon6.7
duodenum6
esophagus5.7
gallbladder15.8
heart muscle7.5
kidney5.6
liver9.9
lung16.4
lymph node14.6
ovary10.9
pancreas5.8
placenta13.9
prostate9.6
salivary gland48.6
skin5.8
small intestine8.6
spleen84.6
stomach6.6
testis5.5
thyroid gland9
urinary bladder15.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*190030, gene) V-fes feline sarcoma viral/v-fps fujinami avian sarcoma viral oncogeneOMIM


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