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> Protein (NX_P07355)
Protein (NX_P07355)
Protein
Gene SymbolANXA2 to neXtProt (NX_P07355)
DescriptionAnnexin A2
Chromosome15
Location15q22.2 (60639333 ~ 60695082) to Ensembl
Sequene Features : Isoforms 2, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of receptor activity
.negative regulation of receptor binding
.protein targeting to plasma membrane
  + 15 more...
.calcium-dependent protein binding
.poly(A) RNA binding
.S100 protein binding
  + 4 more...
.PCSK9-AnxA2 complex
.extracellular exosome
.perinuclear region of cytoplasm
  + 22 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 45 9
2014-09-19protein level
2 36 9
2014-05-27protein level
2 36 36
2014-02-25protein level
2 36 34
2013-12-09protein level
2 26 34
2013-11-01protein level
2 24 25
2013-09-12protein level
2 24 24
2013-08-17protein level
2 24 24
2013-07-15protein level
2 17 24
2013-06-11protein level
2 17 24
2013-02-12protein level
2 8 60
2012-12-20protein level
2 8 60
2012-10-30protein level
2 10 60
2012-10-07protein level
2 10 30
2012-08-24protein level
2 8 30
2012-07-28protein level
2 8 30
2012-06-08protein level
2 12 30
2012-05-07protein level
2 12 30
2012-04-10protein level
2 12 30
2012-01-13protein level
2 12 30
2011-12-20protein level
2 12 30
2011-11-11protein level
2 12 28
2011-08-23protein level
2 12 23
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P07355-1
0 18 0 38579.7043
NX_P07355-2
1 18 0 40385.6019
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-352622,EBI-744248 MLH1  
  .meiotic spindle midzone assembly
.oogenesis
.negative regulation of mitotic recombination
  + 12 more...
.guanine/thymine mispair binding
.ATPase activity
.ATP binding
.MutLalpha complex
.membrane
.chiasma
  + 4 more...
2 EBI-352622,EBI-7539251 PCSK9  
  .negative regulation of sodium ion transmembrane transporter activity
.negative regulation of receptor activity
.positive regulation of neuron apoptotic process
  + 22 more...
.very-low-density lipoprotein particle receptor binding
.low-density lipoprotein particle receptor binding
.poly(A) RNA binding
  + 8 more...
.PCSK9-AnxA2 complex
.PCSK9-LDLR complex
.perinuclear region of cytoplasm
  + 12 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue544
adrenal gland607
ascites753
bladder4320
blood196
bone2583
bone marrow1846
brain178
cervix453
connective tissue1207
ear683
embryonic tissue389
esophagus595
eye397
heart357
intestine732
kidney574
larynx724
liver896
lung818
lymph45
lymph node300
mammary gland958
mouth604
muscle197
nerve1223
ovary1546
pancreas1592
parathyroid1796
pharynx1104
pituitary gland423
placenta438
prostate849
salivary gland1480
skin1366
spleen37
stomach951
testis94
thymus37
thyroid686
tonsil117
trachea77
umbilical cord6684
uterus719
vascular871
Health State
TissuesTPM*
normal372
adrenal tumor1343
bladder carcinoma6483
breast (mammary gland) tumor934
cervical tumor579
chondrosarcoma2667
colorectal tumor1190
esophageal tumor637
gastrointestinal tumor843
germ cell tumor349
glioma774
head and neck tumor1001
kidney tumor1147
leukemia613
liver tumor1520
lung tumor1128
lymphoma124
non-neoplasia341
ovarian tumor1732
pancreatic tumor3037
primitive neuroectodermal tumor of the CNS173
prostate cancer1049
retinoblastoma21
skin tumor1084
soft tissue/muscle tissue tumor630
uterine tumor1198
Developmental Stage
TissuesTPM*
adult741
embryoid body600
blastocyst162
neonate4023
fetus231
infant170
juvenile323
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue163.4
adrenal gland49.3
appendix115.6
bone marrow31.1
cerebral cortex9.2
colon131.7
duodenum105.9
esophagus221.5
gallbladder100.2
heart muscle34.6
kidney35.6
liver37.8
lung179.8
lymph node40.1
ovary32.3
pancreas35.7
placenta132.8
prostate68.1
salivary gland48.7
skin186.9
small intestine109.3
spleen54.8
stomach98.2
testis33.9
thyroid gland36
urinary bladder85
Tissues
TissuesExpression level
appendixMedium
bone marrowLow
breastLow
bronchusHigh
cerebral cortexMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverHigh
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateHigh
rectumMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2High
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*151740, gene) Annexin a2; ANXA2OMIM


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