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> Protein (NX_P07602)
Protein (NX_P07602)
Protein
Gene SymbolPSAP to neXtProt (NX_P07602)
DescriptionProsaposin
Chromosome10
Location10q22.1 (73576055 ~ 73611126) to Ensembl
Sequene Features : Isoforms 3, Variants 67, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to organic substance
.epithelial cell differentiation involved in prostate gland development
.prostate gland growth
  + 10 more...
.lipid binding
.enzyme activator activity
.extracellular exosome
.intracellular membrane-bounded organelle
.lysosomal lumen
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 67 20
2014-09-19protein level
3 59 20
2014-05-27protein level
3 59 20
2014-02-25protein level
3 59 20
2013-12-09protein level
3 42 20
2013-11-01protein level
3 42 20
2013-09-12protein level
3 42 20
2013-08-17protein level
3 42 20
2013-07-15protein level
3 29 18
2013-06-11protein level
3 29 18
2013-02-12protein level
3 21 50
2012-12-20protein level
3 22 50
2012-10-30protein level
3 25 50
2012-10-07protein level
3 25 18
2012-08-24protein level
3 20 18
2012-07-28protein level
3 20 18
2012-06-08protein level
3 9 18
2012-05-07protein level
3 9 18
2012-04-10protein level
3 9 18
2012-01-13protein level
3 9 18
2011-12-20protein level
3 11 18
2011-11-11protein level
3 11 17
2011-08-23protein level
3 11 17
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P07602-1
1 28 0 58073.6878
NX_P07602-2
1 28 0 58316.7727
NX_P07602-3
1 28 0 58444.8309
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-716699,EBI-2510738 CASP14  
  .extrinsic apoptotic signaling pathway in absence of ligand
.cornification
.keratinization
  + 3 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.cysteine-type endopeptidase activity
.extracellular exosome
.keratin filament
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue1165
adrenal gland910
ascites451
blood670
bone809
bone marrow1579
brain812
cervix433
connective tissue610
ear186
embryonic tissue751
esophagus2877
eye885
heart413
intestine711
kidney683
larynx724
liver263
lung955
lymph428
lymph node178
mammary gland846
mouth302
muscle441
nerve1931
ovary827
pancreas1532
parathyroid1165
pharynx417
pituitary gland1391
placenta1377
prostate1060
salivary gland98
skin1271
spleen786
stomach992
testis422
thymus414
thyroid2618
tonsil235
trachea57
umbilical cord290
uterus801
vascular968
Health State
TissuesTPM*
normal571
adrenal tumor1896
bladder carcinoma454
breast (mammary gland) tumor934
cervical tumor579
chondrosarcoma1569
colorectal tumor817
esophageal tumor3363
gastrointestinal tumor886
germ cell tumor338
glioma1987
head and neck tumor1188
kidney tumor1335
leukemia1375
liver tumor354
lung tumor856
lymphoma401
non-neoplasia755
ovarian tumor800
pancreatic tumor2561
primitive neuroectodermal tumor of the CNS606
prostate cancer1627
retinoblastoma323
skin tumor1627
soft tissue/muscle tissue tumor199
uterine tumor1531
Developmental Stage
TissuesTPM*
adult883
embryoid body943
blastocyst846
neonate675
fetus491
infant425
juvenile683
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue460.5
adrenal gland573
appendix583.2
bone marrow401
cerebral cortex475.5
colon366.9
duodenum301.9
esophagus295.2
gallbladder644.2
heart muscle538.5
kidney468.5
liver340
lung594
lymph node648.9
ovary480.9
pancreas194.5
placenta580.1
prostate364.6
salivary gland304
skin232.6
small intestine296.4
spleen684.7
stomach397.1
testis351.2
thyroid gland477.7
urinary bladder545.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176801, gene) Prosaposin; PSAPOMIM
2(#249900, phenotype) Metachromatic leukodystrophy due to saposin b deficiencyOMIM
3(#610539, phenotype) Gaucher disease, atypical, due to saposin c deficiencyOMIM
4(#611721, phenotype) Combined saposin deficiencyOMIM
5(#611722, phenotype) Krabbe disease, atypical, due to saposin a deficiencyOMIM


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