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> Protein (NX_P07910)
Protein (NX_P07910)
Protein
Gene SymbolHNRNPC to neXtProt (NX_P07910)
DescriptionHeterogeneous nuclear ribonucleoproteins C1/C2
Chromosome14
Location14q11.2 (21677295 ~ 21737653) to Ensembl
Sequene Features : Isoforms 4, Variants 36, PTMs 19 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.3'-UTR-mediated mRNA stabilization
.ATP-dependent chromatin remodeling
.gene expression
  + 3 more...
.N6-methyladenosine-containing RNA binding
.poly(A) RNA binding
.identical protein binding
  + 7 more...
.catalytic step 2 spliceosome
.extracellular exosome
.protein complex
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 36 19
2014-09-19protein level
4 28 19
2014-05-27protein level
4 28 26
2014-02-25protein level
4 28 25
2013-12-09protein level
4 24 25
2013-11-01protein level
4 23 23
2013-09-12protein level
4 23 23
2013-08-17protein level
4 23 23
2013-07-15protein level
4 16 19
2013-06-11protein level
4 16 19
2013-02-12protein level
4 8 90
2012-12-20protein level
4 8 90
2012-10-30protein level
4 3 90
2012-10-07protein level
4 3 27
2012-08-24protein level
4 2 27
2012-07-28protein level
4 2 27
2012-06-08protein level
4 10 27
2012-05-07protein level
4 10 27
2012-04-10protein level
4 10 27
2012-01-13protein level
4 13 27
2011-12-20protein level
4 13 27
2011-11-11protein level
4 13 25
2011-08-23protein level
4 13 24
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P07910-1
1 7 8 33649.443
NX_P07910-2
0 8 8 32317.7746
NX_P07910-3
1 5 5 25215.0882
NX_P07910-4
0 8 7 27804.38
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-357966,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-357966,EBI-396343 KPNA4  
  .response to hydrogen peroxide
.cytokine-mediated signaling pathway
.NLS-bearing protein import into nucleus
.protein transporter activity .extracellular exosome
.cytosol
.nucleoplasm
3 EBI-357966,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
4 EBI-357966,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
5 EBI-357966,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
6 EBI-357966,EBI-593303 SRPK2  
  .regulation of mRNA splicing, via spliceosome
.positive regulation of cell cycle
.innate immune response
  + 12 more...
.14-3-3 protein binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
7 EBI-357966,EBI-375576 EPS8  
  .actin polymerization-dependent cell motility
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.Rac GTPase binding
.SH3/SH2 adaptor activity
.actin binding
.extracellular exosome
.ruffle membrane
.stereocilium
  + 6 more...
8 EBI-357966,EBI-741520 RALYL  
  .N/A .poly(A) RNA binding
.identical protein binding
.nucleotide binding
.N/A
9 EBI-357966,EBI-740773 RBM41  
  .N/A .RNA binding
.nucleotide binding
.N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites25
bladder133
blood57
bone13
bone marrow595
brain5
cervix82
connective tissue33
ear559
embryonic tissue42
esophagus645
eye19
heart55
intestine12
kidney322
larynx42
liver19
lung11
lymph1151
lymph node55
mammary gland6
mouth211
muscle9
nerve321
ovary443
pancreas18
parathyroid291
pharynx49
pituitary gland484
placenta14
prostate21
salivary gland789
skin9
spleen18
stomach512
testis9
thymus388
thyroid257
tonsil352
trachea96
umbilical cord72
uterus12
vascular19
Health State
TissuesTPM*
normal17
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor461
cervical tumor115
chondrosarcoma386
colorectal tumor17
esophageal tumor579
gastrointestinal tumor16
germ cell tumor18
glioma363
head and neck tumor7
kidney tumor464
leukemia52
liver tumor41
lung tumor19
lymphoma1454
non-neoplasia10
ovarian tumor406
pancreatic tumor9
primitive neuroectodermal tumor of the CNS1110
prostate cancer38
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult18
embryoid body14
blastocyst48
neonate418
fetus21
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue127
adrenal gland159.3
appendix194.1
bone marrow251.6
cerebral cortex120
colon153.6
duodenum112.3
esophagus132.3
gallbladder151.7
heart muscle103.8
kidney146.3
liver97.7
lung113.5
lymph node233.3
ovary232.7
pancreas59.4
placenta185.3
prostate145.6
salivary gland104.4
skin92.3
small intestine142.2
spleen164.6
stomach127.4
testis95.7
thyroid gland147.1
urinary bladder188.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164020, gene) Heterogeneous nuclear ribonucleoprotein c; HNRNPCOMIM


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