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> Protein (NX_P07947)
Protein (NX_P07947)
Protein
Gene SymbolYES1 to neXtProt (NX_P07947)
DescriptionTyrosine-protein kinase Yes
Chromosome18
Location18p11.32 (721588 ~ 812547) to Ensembl
Sequene Features : Isoforms 1, Variants 60, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 60 18
2014-09-19protein level
1 48 18
2014-05-27protein level
1 48 20
2014-02-25protein level
1 46 20
2013-12-09protein level
1 32 20
2013-11-01protein level
1 31 17
2013-09-12protein level
1 31 17
2013-08-17protein level
1 31 17
2013-07-15protein level
1 17 17
2013-06-11protein level
1 17 17
2013-02-12protein level
1 7 17
2012-12-20protein level
1 7 17
2012-10-30protein level
1 9 17
2012-10-07protein level
1 9 17
2012-08-24protein level
1 7 17
2012-07-28protein level
1 7 17
2012-06-08protein level
1 8 17
2012-05-07protein level
1 8 17
2012-04-10protein level
1 8 17
2012-01-13protein level
1 7 17
2011-12-20protein level
1 7 17
2011-11-11protein level
1 7 18
2011-08-23protein level
1 6 17
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P07947-1
16 0 9 60762.3354
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-515331,EBI-714146 SOCS3  
  .spongiotrophoblast differentiation
.trophoblast giant cell differentiation
.placenta blood vessel development
  + 16 more...
.protein kinase inhibitor activity .cytosol
.cytoplasm
2 EBI-515331,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-515331,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
4 EBI-515331,EBI-79934 ALOX5  
  .lipoxin metabolic process
.small molecule metabolic process
.lipoxygenase pathway
  + 4 more...
.iron ion binding
.arachidonate 5-lipoxygenase activity
.nuclear membrane
.nuclear matrix
.cytosol
  + 3 more...
5 EBI-515331,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
6 EBI-515331,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
7 EBI-515331,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
8 EBI-515331,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
9 EBI-515331,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
10 EBI-515331,EBI-946029 C1orf94  
  .N/A .N/A .N/A
11 EBI-515331,EBI-3059266 FUNDC1  
  .response to hypoxia
.mitochondrion degradation
.N/A .integral component of mitochondrial outer membrane
.mitochondrial outer membrane
12 EBI-515331,EBI-3867416 OLIG1  
  .neuron fate commitment
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .nucleus
13 EBI-515331,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
14 EBI-515331,EBI-2902395 SSBP3  
  .positive regulation of anterior head development
.head morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
  + 6 more...
.single-stranded DNA binding .protein complex
.nucleus
15 EBI-515331,EBI-740897 NIF3L1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of transcription, DNA-templated
.neuron differentiation
.identical protein binding
.transcription factor binding
.mitochondrion
.cytoplasm
.nucleus
16 EBI-515331,EBI-514199 MED28  
  .negative regulation of smooth muscle cell differentiation
.stem cell maintenance
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cortical actin cytoskeleton
.mediator complex
.membrane
17 EBI-515331,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
18 EBI-515331,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland151
ascites25
bladder33
bone55
bone marrow123
brain21
ear248
embryonic tissue65
esophagus198
eye14
heart22
intestine34
kidney66
liver73
lung53
mammary gland46
mouth136
muscle37
ovary29
pancreas32
parathyroid48
pituitary gland121
placenta88
prostate15
salivary gland49
skin33
stomach62
testis66
thymus75
thyroid85
trachea154
uterus81
vascular116
Health State
TissuesTPM*
normal40
adrenal tumor395
breast (mammary gland) tumor32
chondrosarcoma24
colorectal tumor26
esophageal tumor231
gastrointestinal tumor50
germ cell tumor30
glioma9
head and neck tumor74
kidney tumor72
leukemia63
liver tumor83
lung tumor48
non-neoplasia31
ovarian tumor39
primitive neuroectodermal tumor of the CNS7
prostate cancer19
skin tumor31
soft tissue/muscle tissue tumor23
uterine tumor55
Developmental Stage
TissuesTPM*
adult48
embryoid body42
blastocyst65
fetus30
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.7
adrenal gland15.1
appendix12.3
bone marrow2.8
cerebral cortex14.1
colon27.3
duodenum25.5
esophagus26.4
gallbladder23.9
heart muscle11.4
kidney28.5
liver31.5
lung20.2
lymph node6.9
ovary13
pancreas13.6
placenta38.9
prostate17.1
salivary gland17.3
skin16.3
small intestine24.5
spleen23.3
stomach23.3
testis23
thyroid gland24.9
urinary bladder20.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164880, gene) V-yes-1 yamaguchi sarcoma viral oncogene; YES1OMIM


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