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> Protein (NX_P07948)
Protein (NX_P07948)
Protein
Gene SymbolLYN to neXtProt (NX_P07948)
DescriptionTyrosine-protein kinase Lyn
Chromosome8
Location8q12.1 (56792372 ~ 56923940) to Ensembl
Sequene Features : Isoforms 2, Variants 64, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of dendritic cell apoptotic process
.negative regulation of intracellular signal transduction
.dendritic cell differentiation
  + 83 more...
.ion channel binding
.glycosphingolipid binding
.enzyme binding
  + 5 more...
.extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 64 20
2014-09-19protein level
2 45 20
2014-05-27protein level
2 45 21
2014-02-25protein level
2 5 21
2013-12-09protein level
2 1 21
2013-11-01protein level
2 1 21
2013-09-12protein level
2 1 21
2013-08-17protein level
2 1 21
2013-07-15protein level
2 1 21
2013-06-11protein level
2 1 21
2013-02-12protein level
2 1 39
2012-12-20protein level
2 1 39
2012-10-30protein level
2 4 39
2012-10-07protein level
2 4 21
2012-08-24protein level
2 4 20
2012-07-28protein level
2 4 20
2012-06-08protein level
2 14 20
2012-05-07protein level
2 14 20
2012-04-10protein level
2 14 20
2012-01-13protein level
2 14 20
2011-12-20protein level
2 14 20
2011-11-11protein level
2 11 20
2011-08-23protein level
2 11 20
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P07948-1
1 21 3 58536.6331
NX_P07948-2
1 21 3 55997.3041
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-79452,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-79452,EBI-703066 ITGB1  
  .negative regulation of anoikis
.positive regulation of establishment of protein localization to plasma membrane
.response to transforming growth factor beta
  + 57 more...
.collagen binding involved in cell-matrix adhesion
.cell adhesion molecule binding
.protein heterodimerization activity
  + 5 more...
.synaptic membrane
.invadopodium membrane
.extracellular exosome
  + 32 more...
3 EBI-79452,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
4 EBI-79452,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
5 EBI-79452,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
6 EBI-79452,EBI-6139068 CD37  
  .regulation of defense response to virus
.defense response to protozoan
.negative regulation of myeloid dendritic cell activation
  + 3 more...
.N/A .extracellular exosome
.integral component of membrane
.membrane
.immunological synapse
7 EBI-79452,EBI-78277 CD22  
  .cell adhesion .carbohydrate binding .extracellular exosome
.external side of plasma membrane
.integral component of plasma membrane
8 EBI-79452,EBI-6267018 CD24  
  .positive regulation of nephron tubule epithelial cell differentiation
.intrinsic apoptotic signaling pathway
.glomerular parietal epithelial cell differentiation
  + 24 more...
.protein tyrosine kinase activator activity
.protein kinase binding
.signal transducer activity
.membrane raft
.anchored component of membrane
.membrane
  + 2 more...
9 EBI-6895930,EBI-355924 MCM7  
  .cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
10 EBI-79452,EBI-519280 CDKN1B  
  .mitotic cell cycle arrest
.cellular response to organic cyclic compound
.cellular response to lithium ion
  + 39 more...
.protein phosphatase binding
.transforming growth factor beta receptor, cytoplasmic mediator activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.Cul4A-RING E3 ubiquitin ligase complex
.cytosol
.endosome
  + 3 more...
11 EBI-79452,EBI-296739 GNB2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of gastrulation
.regulation of establishment of cell polarity
  + 30 more...
.poly(A) RNA binding
.protein homodimerization activity
.SH2 domain binding
  + 10 more...
.IRE1-RACK1-PP2A complex
.extracellular exosome
.perinuclear region of cytoplasm
  + 11 more...
12 EBI-79452,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
13 EBI-79452,EBI-515278 GP6  
  .leukocyte migration
.platelet activation
.blood coagulation
.enzyme linked receptor protein signaling pathway
.collagen binding
.transmembrane signaling receptor activity
.receptor activity
.tetraspanin-enriched microdomain
.extracellular exosome
.cell surface
  + 2 more...
14 EBI-79452,EBI-2828115 PAG1  
  .negative regulation of T cell activation
.regulation of T cell activation
.T cell receptor signaling pathway
  + 4 more...
.SH2 domain binding
.SH3/SH2 adaptor activity
.membrane raft
.integral component of membrane
.plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
bladder33
blood49
bone13
bone marrow20
brain2
cervix20
connective tissue6
eye14
intestine8
kidney18
larynx42
liver4
lung23
lymph node66
mammary gland6
nerve64
pancreas28
placenta45
prostate5
skin9
spleen37
stomach10
testis2
uterus21
vascular58
Health State
TissuesTPM*
normal17
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma12
colorectal tumor17
gastrointestinal tumor16
germ cell tumor11
glioma27
head and neck tumor7
leukemia42
liver tumor10
lung tumor9
lymphoma41
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
uterine tumor44
Developmental Stage
TissuesTPM*
adult28
embryoid body28
neonate32
fetus25
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue27
adrenal gland15.5
appendix119.8
bone marrow71.1
cerebral cortex10.5
colon23.2
duodenum57.5
esophagus15.4
gallbladder54.8
heart muscle8.8
kidney9.8
liver15.1
lung39.4
lymph node97.9
ovary6.1
pancreas7
placenta46
prostate9.2
salivary gland10.9
skin5.8
small intestine45.8
spleen139
stomach23.1
testis7.5
thyroid gland22.5
urinary bladder52.5
Tissues
TissuesExpression level
appendixMedium
bone marrowMedium
bronchusLow
cerebellumLow
cerebral cortexLow
cervix, uterineLow
colonLow
duodenumMedium
fallopian tubeLow
gallbladderMedium
hippocampusLow
lateral ventricleLow
lungLow
lymph nodeHigh
nasopharynxLow
pancreasLow
placentaMedium
prostateLow
rectumLow
salivary glandLow
seminal vesicleLow
small intestineLow
spleenHigh
stomach 1Low
stomach 2Low
thyroid glandLow
tonsilHigh
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*165120, gene) V-yes-1 yamaguchi sarcoma viral related oncogene homolog; LYNOMIM


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