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> Protein (NX_P07992)
Protein (NX_P07992)
Protein
Gene SymbolERCC1 to neXtProt (NX_P07992)
DescriptionDNA excision repair protein ERCC-1
Chromosome19
Location19q13.32 (45910591 ~ 45982086) to Ensembl
Sequene Features : Isoforms 4, Variants 42, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.chromosome organization
.embryonic organ development
.oogenesis
  + 26 more...
.protein domain specific binding
.protein C-terminus binding
.endonuclease activity
  + 2 more...
.cytoplasm
.transcription factor TFIID complex
.nucleoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 42 3
2014-09-19protein level
4 32 3
2014-05-27protein level
4 32 3
2014-02-25protein level
4 32 3
2013-12-09protein level
4 26 3
2013-11-01protein level
3 26 2
2013-09-12protein level
3 26 1
2013-08-17protein level
3 26 1
2013-07-15protein level
3 17 1
2013-06-11protein level
3 17 1
2013-02-12protein level
3 12 0
2012-12-20protein level
3 12 0
2012-10-30protein level
3 12 0
2012-10-07protein level
3 12 0
2012-08-24protein level
3 9 0
2012-07-28protein level
3 9 0
2012-06-08protein level
3 9 0
2012-05-07protein level
3 9 0
2012-04-10protein level
2 7 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P07992-1
0 14 0 32541.8168
NX_P07992-2
1 12 0 29974.5088
NX_P07992-3
1 13 0 35540.4734
NX_P07992-4
1 11 0 25195.122
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-750962,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-750962,EBI-295222 XPA  
  .multicellular organism growth
.nucleotide-excision repair, DNA incision
.response to toxic substance
  + 6 more...
.metal ion binding
.protein homodimerization activity
.protein domain specific binding
.damaged DNA binding
.intercellular bridge
.Golgi apparatus
.cytoplasm
  + 2 more...
3 EBI-750962,EBI-2340269 MKRN3  
  .protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
4 EBI-750962,EBI-2370740 SLX4  
  .response to intra-S DNA damage checkpoint signaling
.positive regulation of catalytic activity
.DNA double-strand break processing involved in repair via single-strand annealing
  + 4 more...
.5'-flap endonuclease activity
.enzyme activator activity
.Slx1-Slx4 complex
.cell junction
.cytoplasm
.nucleoplasm
5 EBI-750962,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
6 EBI-750962,EBI-2370770 ERCC4  
  .nucleotide-excision repair involved in interstrand cross-link repair
.nucleotide-excision repair, DNA incision
.negative regulation of telomere maintenance
  + 11 more...
.protein N-terminus binding
.protein C-terminus binding
.endodeoxyribonuclease activity
  + 3 more...
.transcription factor TFIID complex
.nucleoplasm
.nucleus
  + 4 more...
7 EBI-750962,EBI-10195625 TRMT2B  
  .RNA processing .S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity .mitochondrion
8 EBI-750962,EBI-348604 UBL7  
  .N/A .N/A .N/A
9 EBI-750962,EBI-4400866 VPS37B  
  .positive regulation of viral budding via host ESCRT complex
.positive regulation of viral release from host cell
.intracellular transport of virus
  + 7 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.midbody
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
blood204
bone139
bone marrow20
brain40
cervix61
connective tissue60
ear62
embryonic tissue61
eye52
heart44
intestine30
kidney37
liver29
lung62
lymph node22
mammary gland138
mouth15
muscle18
nerve128
ovary39
pancreas37
parathyroid48
placenta21
prostate147
salivary gland98
skin71
stomach62
testis18
thyroid85
tonsil58
uterus77
vascular19
Health State
TissuesTPM*
normal37
adrenal tumor158
breast (mammary gland) tumor118
cervical tumor86
chondrosarcoma181
colorectal tumor44
gastrointestinal tumor33
germ cell tumor3
glioma65
head and neck tumor14
kidney tumor43
leukemia264
liver tumor41
lung tumor58
non-neoplasia20
ovarian tumor39
pancreatic tumor76
primitive neuroectodermal tumor of the CNS55
prostate cancer269
retinoblastoma21
skin tumor79
soft tissue/muscle tissue tumor71
uterine tumor44
Developmental Stage
TissuesTPM*
adult74
embryoid body100
blastocyst65
fetus59
infant85
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28.5
adrenal gland37.4
appendix32
bone marrow20.8
cerebral cortex27.5
colon24.1
duodenum29.3
esophagus36.5
gallbladder37
heart muscle71.6
kidney26.5
liver15.9
lung36.2
lymph node34.4
ovary52.5
pancreas28.7
placenta25.6
prostate40.2
salivary gland61.2
skin53.5
small intestine24
spleen33.1
stomach26.5
testis25.2
thyroid gland36.5
urinary bladder33.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*126380, gene) Excision-repair, complementing defective, in chinese hamster, 1; ERCC1OMIM
2(#610758, phenotype) Cerebrooculofacioskeletal syndrome 4; COFS4OMIM


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