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> Protein (NX_P08047)
Protein (NX_P08047)
Protein
Gene SymbolSP1 to neXtProt (NX_P08047)
DescriptionTranscription factor Sp1
Chromosome12
Location12q13.13 (53773960 ~ 53810230) to Ensembl
Sequene Features : Isoforms 3, Variants 77, PTMs 24 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.definitive hemopoiesis
.embryonic process involved in female pregnancy
.embryonic skeletal system development
  + 19 more...
.HMG box domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 16 more...
.protein-DNA complex
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 77 24
2014-09-19protein level
3 52 24
2014-05-27protein level
3 52 24
2014-02-25protein level
1 52 24
2013-12-09protein level
1 42 24
2013-11-01protein level
1 40 24
2013-09-12protein level
1 40 24
2013-08-17protein level
1 40 24
2013-07-15protein level
1 21 24
2013-06-11protein level
1 21 24
2013-02-12protein level
1 10 23
2012-12-20protein level
1 9 23
2012-10-30protein level
1 14 23
2012-10-07protein level
1 14 23
2012-08-24protein level
1 13 23
2012-07-28protein level
1 13 23
2012-06-08protein level
1 58 23
2012-05-07protein level
1 58 23
2012-04-10protein level
1 58 23
2012-01-13protein level
1 52 23
2011-12-20protein level
1 52 23
2011-11-11protein level
1 52 23
2011-08-23protein level
1 52 23
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P08047-1
0 16 0 80643.372
NX_P08047-2
1 15 0 79843.0981
NX_P08047-3
1 14 0 75777.1007
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-298336,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
2 EBI-298336,EBI-78473 ESR1  
  .cellular response to estradiol stimulus
.epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
  + 33 more...
.ATPase binding
.identical protein binding
.estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 14 more...
.transcriptionally active chromatin
.integral component of membrane
.membrane
  + 5 more...
3 EBI-298336,EBI-624770 POU2F1  
  .lens induction in camera-type eye
.negative regulation of transcription, DNA-templated
.olfactory placode formation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.intracellular membrane-bounded organelle
.transcription factor complex
.nucleoplasm
.nucleus
4 EBI-298336,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
5 EBI-298336,EBI-765526 ELF1  
  .negative regulation of T cell receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleoplasm
.nucleus
6 EBI-298336,EBI-396176 HCFC1  
  .protein stabilization
.positive regulation of cell cycle
.histone H4-K16 acetylation
  + 12 more...
.identical protein binding
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.MLL1 complex
.MLL5-L complex
.Set1C/COMPASS complex
  + 7 more...
7 EBI-298336,EBI-448924 E2F1  
  .regulation of G1/S transition of mitotic cell cycle
.lens fiber cell apoptotic process
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.Rb-E2F complex
.cytoplasm
.nucleoplasm
.nucleus
8 EBI-298336,EBI-743342 RUNX1T1  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.generation of precursor metabolites and energy
.metal ion binding
.identical protein binding
.transcription corepressor activity
  + 2 more...
.nuclear matrix
.mitochondrion
.cytoplasm
.nucleoplasm
9 EBI-298336,EBI-465059 SREBF2  
  .regulation of cholesterol homeostasis
.negative regulation of cholesterol efflux
.regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
  + 9 more...
.E-box binding
.protein C-terminus binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.SREBP-SCAP-Insig complex
.ER to Golgi transport vesicle membrane
.cytosol
  + 7 more...
10 EBI-298336,EBI-1389509 KLF10  
  .cellular response to peptide
.negative regulation of transcription, DNA-templated
.positive regulation of osteoclast differentiation
  + 12 more...
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.core promoter sequence-specific DNA binding
.nucleus
11 EBI-298336,EBI-347263 SMAD4  
  .nephrogenic mesenchyme morphogenesis
.metanephric mesenchyme morphogenesis
.response to transforming growth factor beta
  + 49 more...
.R-SMAD binding
.I-SMAD binding
.metal ion binding
  + 9 more...
.SMAD protein complex
.activin responsive factor complex
.cytosol
  + 6 more...
12 EBI-298336,EBI-1054743 SF3A1  
  .gene expression
.RNA splicing
.mRNA processing
  + 3 more...
.poly(A) RNA binding
.RNA binding
.catalytic step 2 spliceosome
.U2-type prespliceosome
.U2 snRNP
  + 3 more...
13 EBI-298336,EBI-447269 HIF1A  
  .negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
14 EBI-298336,EBI-1389308 POGZ  
  .kinetochore assembly
.cell division
.mitotic sister chromatid cohesion
.metal ion binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
.nuclear chromatin
15 EBI-298336,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
16 EBI-298336,EBI-2515601 ZBTB2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
17 EBI-298336,EBI-1752755 DLX4  
  .multicellular organismal development
.regulation of transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
18 EBI-298336,EBI-447470 EPAS1  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.iron ion homeostasis
  + 18 more...
.protein heterodimerization activity
.histone acetyltransferase binding
.transcription factor binding
  + 4 more...
.nuclear speck
.cytosol
.transcription factor complex
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
blood57
bone41
brain32
cervix61
connective tissue60
embryonic tissue145
esophagus99
eye71
heart111
intestine107
kidney80
larynx42
liver34
lung68
lymph node200
mammary gland132
mouth75
muscle65
nerve64
ovary49
pancreas84
parathyroid145
pharynx24
placenta60
prostate63
skin71
spleen37
stomach52
testis68
thymus25
thyroid107
trachea19
uterus73
vascular38
Health State
TissuesTPM*
normal75
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma48
colorectal tumor159
esophageal tumor115
gastrointestinal tumor75
germ cell tumor68
glioma18
head and neck tumor59
kidney tumor43
leukemia63
liver tumor10
lung tumor58
lymphoma13
non-neoplasia20
ovarian tumor65
pancreatic tumor28
primitive neuroectodermal tumor of the CNS39
prostate cancer77
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor39
uterine tumor99
Developmental Stage
TissuesTPM*
adult75
embryoid body100
blastocyst179
fetus105
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.6
adrenal gland18.4
appendix24.9
bone marrow19.6
cerebral cortex9.5
colon25
duodenum28.4
esophagus30.1
gallbladder28.7
heart muscle11.4
kidney18.9
liver9.2
lung21.9
lymph node24.8
ovary32.3
pancreas9
placenta26.6
prostate18.5
salivary gland17.8
skin33.8
small intestine29.8
spleen27.4
stomach27.8
testis25.5
thyroid gland22.3
urinary bladder30.3
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*189906, gene) Transcription factor sp1; SP1OMIM


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