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> Protein (NX_P08069)
Protein (NX_P08069)
Protein
Gene SymbolIGF1R to neXtProt (NX_P08069)
DescriptionInsulin-like growth factor 1 receptor
Chromosome15
Location15q26.3 (99192200 ~ 99507759) to Ensembl
Sequene Features : Isoforms 1, Variants 186, PTMs 42 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of steroid hormone biosynthetic process
.prostate gland epithelium morphogenesis
.negative regulation of protein kinase B signaling
  + 30 more...
.insulin receptor substrate binding
.insulin binding
.phosphatidylinositol 3-kinase binding
  + 7 more...
.receptor complex
.intracellular membrane-bounded organelle
.neuron projection
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 186 42
2014-09-19protein level
1 138 42
2014-05-27protein level
1 138 42
2014-02-25protein level
1 133 42
2013-12-09protein level
1 118 40
2013-11-01protein level
1 113 39
2013-09-12protein level
1 113 39
2013-08-17protein level
1 113 39
2013-07-15protein level
1 81 40
2013-06-11protein level
1 81 40
2013-02-12protein level
1 53 40
2012-12-20protein level
1 42 40
2012-10-30protein level
1 46 40
2012-10-07protein level
1 46 38
2012-08-24protein level
1 45 38
2012-07-28protein level
1 45 38
2012-06-08protein level
1 52 38
2012-05-07protein level
1 38 38
2012-04-10protein level
1 38 38
2012-01-13protein level
1 38 38
2011-12-20protein level
1 38 32
2011-11-11protein level
1 38 32
2011-08-23protein level
1 38 32
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P08069-1
63 0 4 154692.747
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-475981,EBI-7902275 IGF1  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of myoblast proliferation
.positive regulation of trophectodermal cell proliferation
  + 81 more...
.hormone activity
.integrin binding
.insulin-like growth factor receptor binding
.insulin receptor binding
.platelet alpha granule lumen
.insulin-like growth factor binding protein complex
.plasma membrane
  + 2 more...
2 EBI-475981,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
3 EBI-475981,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
4 EBI-475981,EBI-1000553 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
5 EBI-475981,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
6 EBI-475981,EBI-1380630 CSK  
  .cellular response to peptide hormone stimulus
.negative regulation of ERK1 and ERK2 cascade
.regulation of Fc receptor mediated stimulatory signaling pathway
  + 26 more...
.identical protein binding
.protein C-terminus binding
.ATP binding
  + 3 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 4 more...
7 EBI-475981,EBI-6378485 CAMP  
  .phagosome maturation
.killing by host of symbiont cells
.interaction with host
  + 5 more...
.N/A .extracellular exosome
.cytosol
.cell wall
.extracellular space
8 EBI-475981,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
9 EBI-475981,EBI-1054248 TAGLN  
  .epithelial cell differentiation
.muscle organ development
.N/A .cytoplasm
10 EBI-475981,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
11 EBI-475981,EBI-821440 ARHGEF12  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.neurotrophin TRK receptor signaling pathway
  + 5 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.G-protein coupled receptor binding
.extracellular exosome
.membrane
.cytosol
.cytoplasm
12 EBI-475981,EBI-926131 LEF1  
  .apoptotic process involved in patterning of blood vessels
.negative regulation of canonical Wnt signaling pathway
.positive regulation of cell cycle process
  + 67 more...
.C2H2 zinc finger domain binding
.armadillo repeat domain binding
.gamma-catenin binding
  + 17 more...
.protein-DNA complex
.cytoplasm
.transcription factor complex
  + 2 more...
13 EBI-475981,EBI-751501 KCNIP3  
  .regulation of potassium ion transmembrane transport
.protein localization to plasma membrane
.behavioral response to pain
  + 8 more...
.sequence-specific DNA binding
.potassium channel regulator activity
.calcium ion binding
  + 4 more...
.axon terminus
.protein-DNA complex
.dendrite
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites25
bladder33
blood32
bone111
bone marrow41
brain36
cervix82
connective tissue13
ear186
embryonic tissue263
esophagus49
eye90
heart11
intestine60
kidney33
larynx213
liver63
lung77
lymph node11
mammary gland99
mouth30
muscle47
ovary108
pancreas168
pituitary gland302
placenta98
prostate94
skin80
stomach41
testis78
thymus50
thyroid107
trachea38
uterus38
vascular38
Health State
TissuesTPM*
normal80
adrenal tumor79
breast (mammary gland) tumor96
cervical tumor115
chondrosarcoma48
colorectal tumor79
esophageal tumor57
gastrointestinal tumor33
germ cell tumor56
glioma102
head and neck tumor67
kidney tumor29
leukemia21
liver tumor41
lung tumor29
lymphoma13
non-neoplasia72
ovarian tumor65
pancreatic tumor95
primitive neuroectodermal tumor of the CNS7
prostate cancer77
retinoblastoma43
skin tumor87
soft tissue/muscle tissue tumor31
uterine tumor88
Developmental Stage
TissuesTPM*
adult84
embryoid body400
blastocyst309
fetus86
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.4
adrenal gland8.3
appendix5.2
bone marrow8.8
cerebral cortex5.9
colon5.6
duodenum2.5
esophagus7.9
gallbladder6.9
heart muscle8.3
kidney13
liver1.5
lung7.3
lymph node3.7
ovary16.5
pancreas8
placenta15.1
prostate13.3
salivary gland6.6
skin8
small intestine3.3
spleen4.7
stomach5.3
testis14.6
thyroid gland14.9
urinary bladder8.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*147370, gene) Insulin-like growth factor i receptor; IGF1ROMIM
2(#270450, phenotype) Insulin-like growth factor i, resistance toOMIM


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