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> Protein (NX_P08151)
Protein (NX_P08151)
Protein
Gene SymbolGLI1 to neXtProt (NX_P08151)
DescriptionZinc finger protein GLI1
Chromosome12
Location12q13.3 (57853918 ~ 57866045) to Ensembl
Sequene Features : Isoforms 3, Variants 193, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of canonical Wnt signaling pathway
.notochord regression
.digestive tract morphogenesis
  + 17 more...
.metal ion binding
.transcription regulatory region DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  + 2 more...
.ciliary base
.ciliary tip
.primary cilium
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 193 1
2014-09-19protein level
3 139 1
2014-05-27protein level
3 139 1
2014-02-25protein level
2 138 1
2013-12-09protein level
2 102 1
2013-11-01protein level
2 96 1
2013-09-12protein level
2 96 1
2013-08-17protein level
2 96 1
2013-07-15protein level
2 71 1
2013-06-11protein level
2 71 1
2013-02-12protein level
2 43 2
2012-12-20protein level
2 43 2
2012-10-30protein level
2 44 2
2012-10-07protein level
2 44 1
2012-08-24protein level
2 43 1
2012-07-28protein level
2 43 0
2012-06-08protein level
2 44 0
2012-05-07protein level
2 28 0
2012-04-10protein level
2 28 0
2012-01-13protein level
2 20 0
2011-12-20protein level
1 19 0
2011-11-11protein level
1 19 0
2011-08-23protein level
1 19 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P08151-1
2 38 6 117829.7882
NX_P08151-2
1 38 6 113603.8841
NX_P08151-3
1 35 6 104561.3244
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-308084,EBI-1775921 RPS6KB1  
  .negative regulation of extrinsic apoptotic signaling pathway
.cellular response to growth factor stimulus
.response to glucocorticoid
  + 37 more...
.peptide binding
.ATP binding
.protein serine/threonine/tyrosine kinase activity
  + 2 more...
.perinuclear region of cytoplasm
.synapse
.neuron projection
  + 8 more...
2 EBI-308084,EBI-3504450 VHL  
  .cellular response to hypoxia
.negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 10 more...
.ubiquitin protein ligase activity
.enzyme binding
.transcription factor binding
.ubiquitin-protein transferase activity
.intermediate filament cytoskeleton
.VCB complex
.membrane
  + 5 more...
3 EBI-308084,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
4 EBI-308084,EBI-746252 GCC1  
  .protein targeting to Golgi .N/A .plasma membrane
.Golgi apparatus
.cytoplasm
.Golgi membrane
5 EBI-308084,EBI-1564678 ITCH  
  .regulation of protein deubiquitination
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
  + 21 more...
.ubiquitin protein ligase activity
.CXCR chemokine receptor binding
.ribonucleoprotein complex binding
  + 2 more...
.extracellular exosome
.cytoplasmic vesicle
.membrane
  + 5 more...
6 EBI-308084,EBI-863797 STK36  
  .regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of smoothened signaling pathway
.cilium assembly
  + 5 more...
.transcription factor binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
.nucleus
7 EBI-308084,EBI-740595 SUFU  
  .negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.negative regulation of smoothened signaling pathway
  + 15 more...
.protein kinase binding
.transcription factor binding
.signal transducer activity
.transcription corepressor activity
.ciliary base
.ciliary tip
.primary cilium
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain4
connective tissue6
embryonic tissue37
eye9
kidney14
lymph67
mouth15
muscle253
ovary9
skin4
testis9
uterus12
Health State
TissuesTPM*
normal6
chondrosarcoma12
germ cell tumor18
head and neck tumor7
lymphoma41
skin tumor7
soft tissue/muscle tissue tumor231
Developmental Stage
TissuesTPM*
adult3
embryoid body28
blastocyst32
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.2
adrenal gland2.1
appendix2.2
colon3.6
duodenum3.1
gallbladder4.6
heart muscle1.5
kidney1.6
lung1.6
prostate4.3
salivary gland1.3
small intestine3.7
spleen1.1
stomach2.7
testis7.2
urinary bladder3.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*165220, gene) Glioma-associated oncogene homolog; GLIOMIM


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