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> Protein (NX_P08238)
Protein (NX_P08238)
Protein
Gene SymbolHSP90AB1 to neXtProt (NX_P08238)
DescriptionHeat shock protein HSP 90-beta
Chromosome6
Location6p21.1 (44214824 ~ 44221620) to Ensembl
Sequene Features : Isoforms 1, Variants 91, PTMs 34 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 91 34
2014-09-19protein level
1 72 34
2014-05-27protein level
1 72 69
2014-02-25protein level
1 72 69
2013-12-09protein level
1 61 70
2013-11-01protein level
1 57 54
2013-09-12protein level
1 57 54
2013-08-17protein level
1 57 54
2013-07-15protein level
1 28 33
2013-06-11protein level
1 28 33
2013-02-12protein level
1 12 31
2012-12-20protein level
1 13 31
2012-10-30protein level
1 13 31
2012-10-07protein level
1 13 29
2012-08-24protein level
1 10 29
2012-07-28protein level
1 10 29
2012-06-08protein level
1 15 29
2012-05-07protein level
1 10 29
2012-04-10protein level
1 10 29
2012-01-13protein level
1 25 28
2011-12-20protein level
1 25 28
2011-11-11protein level
1 25 22
2011-08-23protein level
1 25 20
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P08238-1
19 0 13 83211.8671
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-352572,EBI-704197 AIP  
  .regulation of nucleic acid-templated transcription
.negative regulation of cyclic-nucleotide phosphodiesterase activity
.protein maturation by protein folding
  + 4 more...
.unfolded protein binding
.GAF domain binding
.transcription factor binding
  + 2 more...
.membrane
.cytosol
.cytoplasm
.nucleoplasm
2 EBI-352572,EBI-974488 CHEK1  
  .regulation of histone H3-K9 acetylation
.negative regulation of DNA biosynthetic process
.replicative senescence
  + 17 more...
.histone kinase activity (H3-T11 specific)
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.intracellular membrane-bounded organelle
.cytosol
.centrosome
  + 6 more...
3 EBI-352572,EBI-81266 IKBKB  
  .positive regulation of cation channel activity
.cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
  + 32 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
4 EBI-352572,EBI-6423196 MUSK  
  .positive regulation of protein geranylgeranylation
.skeletal muscle acetylcholine-gated channel clustering
.protein autophosphorylation
  + 12 more...
.ATP binding
.transmembrane receptor protein tyrosine kinase activity
.protein tyrosine kinase activity
.postsynaptic membrane
.receptor complex
.neuromuscular junction
  + 2 more...
5 EBI-352572,EBI-6425658 FBXO24  
  .protein ubiquitination .ubiquitin-protein transferase activity .ubiquitin ligase complex
6 EBI-352572,EBI-3905991 NR1I2  
  .drug export
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 9 more...
.zinc ion binding
.drug binding
.ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 4 more...
.nucleoplasm
7 EBI-352572,EBI-1043945 CDK14  
  .regulation of canonical Wnt signaling pathway
.regulation of cell cycle
.cell division
  + 2 more...
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.plasma membrane
.cytosol
.cytoplasm
  + 2 more...
8 EBI-352572,EBI-448610 AHSA1  
  .positive regulation of ATPase activity
.response to stress
.chaperone binding
.ATPase activator activity
.extracellular exosome
.cytosol
.endoplasmic reticulum
.cytoplasm
9 EBI-352572,EBI-2557598 ECD  
  .regulation of G1/S transition of mitotic cell cycle
.cell proliferation
.transcription from RNA polymerase II promoter
  + 2 more...
.transcription coactivator activity .cytoplasm
.nucleoplasm
10 EBI-352572,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
11 EBI-352572,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
12 EBI-352572,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
13 EBI-352572,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
14 EBI-352572,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
15 EBI-352572,EBI-1383732 FGR  
  .cellular response to peptide hormone stimulus
.defense response to Gram-positive bacterium
.regulation of phagocytosis
  + 22 more...
.Fc-gamma receptor I complex binding
.immunoglobulin receptor binding
.protein kinase binding
  + 4 more...
.extracellular exosome
.ruffle membrane
.extrinsic component of cytoplasmic side of plasma membrane
  + 5 more...
16 EBI-352572,EBI-365961 ARAF  
  .negative regulation of apoptotic process
.positive regulation of peptidyl-serine phosphorylation
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.metal ion binding
.ATP binding
.receptor signaling protein activity
  + 2 more...
.N/A
17 EBI-352572,EBI-366233 MAPT  
  .regulation of microtubule-based movement
.generation of neurons
.axon extension
  + 13 more...
.lipoprotein particle binding
.apolipoprotein binding
.enzyme binding
  + 3 more...
.tubulin complex
.cytoplasmic ribonucleoprotein granule
.nuclear periphery
  + 7 more...
18 EBI-352572,EBI-3922781 PSKH1  
  .N/A .ATP binding
.protein serine/threonine kinase activity
.nuclear speck
.plasma membrane
.microtubule organizing center
  + 2 more...
19 EBI-352572,EBI-295644 CDK4  
  .negative regulation of cell cycle arrest
.response to hyperoxia
.cell division
  + 20 more...
.cyclin binding
.cyclin-dependent protein serine/threonine kinase regulator activity
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.perinuclear region of cytoplasm
.nuclear membrane
.tight junction
  + 7 more...
20 EBI-352572,EBI-365980 BRAF  
  .negative regulation of endothelial cell apoptotic process
.negative regulation of synaptic vesicle exocytosis
.positive regulation of substrate adhesion-dependent cell spreading
  + 28 more...
.identical protein binding
.ATP binding
.calcium ion binding
  + 3 more...
.cell body
.neuron projection
.plasma membrane
  + 3 more...
21 EBI-352572,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
22 EBI-352572,EBI-348399 FGFR3  
  .fibroblast growth factor receptor apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.cochlea development
  + 51 more...
.fibroblast growth factor binding
.ATP binding
.fibroblast growth factor-activated receptor activity
.protein tyrosine kinase activity
.perinuclear region of cytoplasm
.transport vesicle
.cell surface
  + 8 more...
23 EBI-352572,EBI-2679622 PRKACB  
  .negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.response to clozapine
.cellular response to glucagon stimulus
  + 26 more...
.ubiquitin protein ligase binding
.ATP binding
.cAMP-dependent protein kinase activity
.magnesium ion binding
.ciliary base
.extracellular exosome
.perinuclear region of cytoplasm
  + 5 more...
24 EBI-352572,EBI-702104 EPHA2  
  .activation of GTPase activity
.positive regulation of establishment of protein localization to plasma membrane
.response to growth factor
  + 31 more...
.ATP binding
.ephrin receptor activity
.transmembrane receptor protein tyrosine kinase activity
.ruffle membrane
.lamellipodium membrane
.leading edge membrane
  + 4 more...
25 EBI-352572,EBI-1383454 TYK2  
  .regulation of type I interferon-mediated signaling pathway
.type I interferon signaling pathway
.innate immune response
  + 8 more...
.ATP binding
.growth hormone receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoskeleton
  + 3 more...
26 EBI-352572,EBI-3906061 MAPK4  
  .cell cycle
.protein phosphorylation
.MAPK cascade
.protein homodimerization activity
.protein kinase binding
.ATP binding
.MAP kinase activity
.cytoplasm
.nucleus
27 EBI-352572,EBI-296058 AKT2  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of cell motility
.positive regulation of protein targeting to membrane
  + 24 more...
.kinase activity
.ATP binding
.protein serine/threonine kinase activity
.ruffle membrane
.cell cortex
.plasma membrane
  + 3 more...
28 EBI-352572,EBI-1005467 FLT4  
  .positive regulation of protein kinase C signaling
.positive regulation of ERK1 and ERK2 cascade
.regulation of blood vessel remodeling
  + 19 more...
.protein phosphatase binding
.growth factor binding
.ATP binding
  + 2 more...
.receptor complex
.integral component of plasma membrane
.plasma membrane
  + 3 more...
29 EBI-352572,EBI-1384128 ACVR1B  
  .positive regulation of trophoblast cell migration
.extrinsic apoptotic signaling pathway
.protein autophosphorylation
  + 18 more...
.metal ion binding
.SMAD binding
.inhibin binding
  + 6 more...
.extracellular exosome
.activin receptor complex
.receptor complex
  + 3 more...
30 EBI-352572,EBI-354900 MAP3K8  
  .regulation of apoptotic process
.activation of protein kinase activity
.T cell costimulation
  + 5 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.magnesium ion binding
.cytosol
.cytoplasm
31 EBI-352572,EBI-751664 MATK  
  .innate immune response
.regulation of cell proliferation
.peptidyl-tyrosine autophosphorylation
  + 8 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytosol
32 EBI-352572,EBI-749343 CSNK1E  
  .positive regulation of canonical Wnt signaling pathway
.regulation of circadian rhythm
.cellular protein localization
  + 14 more...
.poly(A) RNA binding
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.ribonucleoprotein complex
.cytosol
.cytoplasm
.nucleus
33 EBI-352572,EBI-6426927 RGS6  
  .positive regulation of neuron differentiation
.positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
  + 3 more...
.GTPase activator activity
.signal transducer activity
.plasma membrane
.heterotrimeric G-protein complex
.Golgi apparatus
.cytoplasm
34 EBI-352572,EBI-1044067 GSK3A  
  .positive regulation of glycogen (starch) synthase activity
.negative regulation of glycogen (starch) synthase activity
.negative regulation of type B pancreatic cell development
  + 33 more...
.tau-protein kinase activity
.protein kinase A catalytic subunit binding
.ATP binding
.protein serine/threonine kinase activity
.beta-catenin destruction complex
.cytosol
35 EBI-352572,EBI-1383449 CDK9  
  .positive regulation of histone H2B ubiquitination
.positive regulation of mRNA 3'-UTR binding
.negative regulation of mRNA polyadenylation
  + 18 more...
.transcription regulatory region DNA binding
.snRNA binding
.RNA polymerase II carboxy-terminal domain kinase activity
  + 5 more...
.intracellular membrane-bounded organelle
.PML body
.membrane
  + 4 more...
36 EBI-352572,EBI-4302903 PRKX  
  .regulation of epithelial cell differentiation involved in kidney development
.kidney morphogenesis
.epithelial tube morphogenesis
  + 10 more...
.ATP binding
.cAMP-dependent protein kinase activity
.cytoplasm
.nucleus
37 EBI-352572,EBI-1384350 LIMK2  
  .phosphorylation
.spermatogenesis
.zinc ion binding
.ATP binding
.protein serine/threonine kinase activity
.cis-Golgi network
.cytoplasm
.nucleus
38 EBI-352572,EBI-3951604 MAP3K9  
  .protein autophosphorylation
.positive regulation of apoptotic process
.activation of JUN kinase activity
  + 5 more...
.protein homodimerization activity
.ATP binding
.protein tyrosine kinase activity
  + 3 more...
.N/A
39 EBI-352572,EBI-295663 CDK6  
  .negative regulation of cellular senescence
.regulation of cell motility
.hematopoietic stem cell differentiation
  + 26 more...
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.cytosol
.centrosome
.cytoplasm
  + 4 more...
40 EBI-352572,EBI-6422642 ROR2  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.Wnt signaling pathway, planar cell polarity pathway
  + 14 more...
.Wnt-protein binding
.ATP binding
.transmembrane receptor protein tyrosine kinase activity
.clathrin-coated endocytic vesicle membrane
.integral component of plasma membrane
.plasma membrane
41 EBI-352572,EBI-706254 PRKCE  
  .positive regulation of cellular glucuronidation
.negative regulation of sodium ion transmembrane transporter activity
.positive regulation of wound healing
  + 37 more...
.metal ion binding
.ethanol binding
.receptor activator activity
  + 8 more...
.cell periphery
.perinuclear region of cytoplasm
.plasma membrane
  + 7 more...
42 EBI-352572,EBI-295351 PRKCZ  
  .positive regulation of interleukin-10 secretion
.positive regulation of interleukin-13 secretion
.positive regulation of interleukin-5 secretion
  + 38 more...
.metal ion binding
.insulin receptor substrate binding
.potassium channel regulator activity
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical cortex
  + 17 more...
43 EBI-352572,EBI-624835 BTK  
  .apoptotic signaling pathway
.cellular response to molecule of fungal origin
.positive regulation of NF-kappaB transcription factor activity
  + 28 more...
.metal ion binding
.identical protein binding
.phosphatidylinositol-3,4,5-trisphosphate binding
  + 3 more...
.perinuclear region of cytoplasm
.membrane raft
.intracellular membrane-bounded organelle
  + 7 more...
44 EBI-352572,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
45 EBI-352572,EBI-1383465 CAMK2G  
  .regulation of relaxation of cardiac muscle
.regulation of cellular response to heat
.interferon-gamma-mediated signaling pathway
  + 13 more...
.protein homodimerization activity
.ATP binding
.calmodulin binding
  + 2 more...
.sarcoplasmic reticulum membrane
.endocytic vesicle membrane
.membrane
  + 3 more...
46 EBI-352572,EBI-456129 CUL3  
  .intrinsic apoptotic signaling pathway
.negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
  + 22 more...
.POZ domain binding .extracellular exosome
.Cul3-RING ubiquitin ligase complex
.membrane
  + 4 more...
47 EBI-352572,EBI-307369 IKBKE  
  .innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.NIK/NF-kappaB signaling
  + 9 more...
.IkappaB kinase activity
.ATP binding
.NF-kappaB-inducing kinase activity
.mitochondrial membrane
.PML body
.endosome membrane
  + 4 more...
48 EBI-352572,EBI-1646959 CDK10  
  .positive regulation of MAPK cascade
.negative regulation of cell proliferation
.traversing start control point of mitotic cell cycle
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
49 EBI-352572,EBI-1181072 PRKD1  
  .regulation of integrin-mediated signaling pathway
.positive regulation of endothelial cell chemotaxis
.positive regulation of histone deacetylase activity
  + 34 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 2 more...
.cell cortex
.cell-cell junction
.integral component of plasma membrane
  + 6 more...
50 EBI-352572,EBI-458376 STK38  
  .negative regulation of MAP kinase activity
.intracellular signal transduction
.protein phosphorylation
.cellular protein modification process
.mitogen-activated protein kinase kinase kinase binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.MLL5-L complex
.cytoplasm
.nucleus
51 EBI-352572,EBI-80371 ERBB4  
  .positive regulation of STAT protein import into nucleus
.positive regulation of ERK1 and ERK2 cascade
.cardiac muscle tissue regeneration
  + 33 more...
.transcription regulatory region DNA binding
.protein homodimerization activity
.ATP binding
  + 4 more...
.receptor complex
.basolateral plasma membrane
.integral component of membrane
  + 7 more...
52 EBI-352572,EBI-963034 RPS6KA1  
  .positive regulation of hepatic stellate cell activation
.hepatocyte proliferation
.stress-activated MAPK cascade
  + 27 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ATP binding
.protein serine/threonine/tyrosine kinase activity
  + 3 more...
.cytosol
.spindle
.cytoplasm
  + 2 more...
53 EBI-352572,EBI-306838 STK11  
  .intrinsic apoptotic signaling pathway by p53 class mediator
.cellular response to UV-B
.negative regulation of epithelial cell proliferation involved in prostate gland development
  + 35 more...
.protein kinase activator activity
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.extracellular exosome
.TCR signalosome
.membrane
  + 4 more...
54 EBI-352572,EBI-295634 CDC37  
  .regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
55 EBI-352572,EBI-6423788 AMHR2  
  .negative regulation of anti-Mullerian hormone signaling pathway
.sex differentiation
.transforming growth factor beta receptor signaling pathway
  + 2 more...
.anti-Mullerian hormone receptor activity
.metal ion binding
.hormone binding
  + 4 more...
.integral component of plasma membrane
56 EBI-352572,EBI-1381484 DDR2  
  .positive regulation of extracellular matrix disassembly
.positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of fibroblast proliferation
  + 16 more...
.protein tyrosine kinase collagen receptor activity
.ATP binding
.collagen binding
.transmembrane receptor protein tyrosine kinase activity
.extracellular exosome
.apical plasma membrane
.focal adhesion
  + 2 more...
57 EBI-352572,EBI-6426443 KLHL38  
  .N/A .N/A .N/A
58 EBI-352572,EBI-2841876 CDC37L1  
  .protein stabilization
.protein folding
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.cytoplasm
59 EBI-352572,EBI-9363363 UNC45B  
  .chaperone-mediated protein folding
.cell differentiation
.muscle organ development
.N/A .cytosol
.cytoplasm
60 EBI-352572,EBI-1044009 NEK9  
  .cell division
.mitotic nuclear envelope disassembly
.mitotic nuclear division
  + 2 more...
.metal ion binding
.protein kinase binding
.ATP binding
.protein serine/threonine kinase activity
.cytosol
.nucleus
61 EBI-352572,EBI-1237328 GSG2  
  .histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore
.negative regulation of G1/S transition of mitotic cell cycle
.regulation of spindle checkpoint
  + 4 more...
.histone kinase activity (H3-T3 specific)
.ATP binding
.protein kinase activity
.DNA binding
.spindle
.centrosome
.cytoplasm
  + 2 more...
62 EBI-352572,EBI-6123466 FAM162A  
  .positive regulation of release of cytochrome c from mitochondria
.cellular response to hypoxia
.neuron apoptotic process
  + 3 more...
.N/A .extracellular exosome
.integral component of membrane
.mitochondrion
  + 2 more...
63 EBI-352572,EBI-624291 AURKB  
  .regulation of chromosome segregation
.mitotic spindle midzone assembly
.protein autophosphorylation
  + 20 more...
.metal ion binding
.histone serine kinase activity
.ATP binding
  + 2 more...
.spindle midzone
.chromosome passenger complex
.spindle pole centrosome
  + 8 more...
64 EBI-352572,EBI-1051975 CDK15  
  .N/A .metal ion binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein serine/threonine kinase activity
.N/A
65 EBI-352572,EBI-1384110 TESK2  
  .focal adhesion assembly
.actin cytoskeleton organization
.spermatogenesis
.protein phosphorylation
.metal ion binding
.ATP binding
.protein tyrosine kinase activity
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
66 EBI-352572,EBI-358011 MAP3K14  
  .cellular response to mechanical stimulus
.innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 9 more...
.ATP binding
.MAP kinase kinase kinase activity
.MAP kinase kinase activity
  + 3 more...
.cytosol
.cytoplasm
67 EBI-352572,EBI-851883 TSSK6  
  .intracellular signal transduction
.sperm chromatin condensation
.regulation of signal transduction
  + 2 more...
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
.nucleus
68 EBI-352572,EBI-2555775 POGK  
  .multicellular organismal development
.regulation of transcription, DNA-templated
.DNA binding .nucleus
69 EBI-352572,EBI-356402 TBK1  
  .defense response to virus
.defense response to Gram-positive bacterium
.positive regulation of transcription from RNA polymerase II promoter
  + 20 more...
.phosphoprotein binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.endosome membrane
.cytosol
.cytoplasm
70 EBI-352572,EBI-724253 FBXL2  
  .SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
.protein ubiquitination
.viral process
  + 5 more...
.phosphatidylinositol 3-kinase regulatory subunit binding
.protein phosphatase binding
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.membrane
.cytoplasm
71 EBI-352572,EBI-914727 FBXW2  
  .protein ubiquitination
.proteolysis
.cellular protein modification process
.ubiquitin-protein transferase activity .cytoplasm
72 EBI-352572,EBI-527363 AGO1  
  .phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 15 more...
.pre-miRNA binding
.poly(A) RNA binding
.miRNA binding
  + 6 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.ribonucleoprotein complex
  + 7 more...
73 EBI-352572,EBI-357361 ALK  
  .positive regulation of NF-kappaB transcription factor activity
.neuron development
.protein autophosphorylation
  + 8 more...
.identical protein binding
.ATP binding
.transmembrane receptor protein tyrosine kinase activity
  + 2 more...
.extracellular exosome
.protein complex
.integral component of plasma membrane
74 EBI-352572,EBI-357085 STUB1  
  .positive regulation of chaperone-mediated protein complex assembly
.cellular response to misfolded protein
.protein K63-linked ubiquitination
  + 16 more...
.ubiquitin protein ligase activity
.Hsp90 protein binding
.misfolded protein binding
  + 12 more...
.extracellular exosome
.intermediate filament cytoskeleton
.nuclear inclusion body
  + 7 more...
75 EBI-352572,EBI-6381479 ICK  
  .cilium assembly
.intraciliary transport
.intracellular signal transduction
  + 3 more...
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein serine/threonine kinase activity
.magnesium ion binding
.ciliary tip
.ciliary basal body
.cytosol
.nucleus
76 EBI-352572,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue1010
adrenal gland1335
ascites2133
bladder1707
blood1161
bone251
bone marrow2995
brain1823
cervix1319
connective tissue597
ear434
embryonic tissue1869
esophagus1637
eye1613
heart960
intestine1275
kidney1352
larynx1022
liver1753
lung1099
lymph2911
lymph node590
mammary gland1897
mouth1511
muscle1692
nerve1673
ovary1950
pancreas852
parathyroid145
pharynx883
pituitary gland726
placenta703
prostate1361
salivary gland1431
skin2761
spleen1704
stomach700
testis1498
thymus953
thyroid1567
tonsil1821
trachea1081
umbilical cord1162
uterus1594
vascular1994
Health State
TissuesTPM*
adrenal tumor790
bladder carcinoma1251
breast (mammary gland) tumor2277
cervical tumor1652
chondrosarcoma519
colorectal tumor1697
esophageal tumor1681
gastrointestinal tumor1400
germ cell tumor3194
glioma1194
head and neck tumor1337
kidney tumor1974
leukemia1481
liver tumor2613
lung tumor2082
lymphoma2423
non-neoplasia496
ovarian tumor1522
pancreatic tumor1590
primitive neuroectodermal tumor of the CNS3204
prostate cancer1540
retinoblastoma4349
skin tumor4059
soft tissue/muscle tissue tumor1684
uterine tumor1709
Developmental Stage
TissuesTPM*
adult1026
embryoid body1586
blastocyst2668
neonate1448
fetus1350
infant2722
juvenile3005
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue229.2
adrenal gland332.5
appendix233.9
bone marrow181
cerebral cortex311.4
colon197.6
duodenum128.3
esophagus196.6
gallbladder224.7
heart muscle302.6
kidney188.4
liver137.4
lung189.9
lymph node253
ovary643.3
pancreas145.4
placenta254.9
prostate253.8
salivary gland169.1
skin192.6
small intestine135
spleen167
stomach187.3
testis176.9
thyroid gland283.9
urinary bladder237
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateHigh
rectumMedium
salivary glandLow
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1High
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*140572, gene) Heat-shock protein, 90-kd, alpha, class b, member 1; HSP90AB1OMIM


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