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> Protein (NX_P08581)
Protein (NX_P08581)
Protein
Gene SymbolMET to neXtProt (NX_P08581)
DescriptionHepatocyte growth factor receptor
Chromosome7
Location7q31.2 (116312444 ~ 116438440) to Ensembl
Sequene Features : Isoforms 3, Variants 243, PTMs 35 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 243 35
2014-09-19protein level
3 195 35
2014-05-27protein level
3 195 35
2014-02-25protein level
3 190 35
2013-12-09protein level
3 165 35
2013-11-01protein level
3 164 34
2013-09-12protein level
3 164 34
2013-08-17protein level
3 164 34
2013-07-15protein level
3 98 34
2013-06-11protein level
3 98 34
2013-02-12protein level
3 55 88
2012-12-20protein level
3 53 88
2012-10-30protein level
3 59 88
2012-10-07protein level
3 59 35
2012-08-24protein level
3 56 35
2012-07-28protein level
3 56 35
2012-06-08protein level
3 63 35
2012-05-07protein level
3 44 35
2012-04-10protein level
3 44 35
2012-01-13protein level
2 72 25
2011-12-20protein level
2 72 25
2011-11-11protein level
2 72 25
2011-08-23protein level
2 72 25
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P08581-1
1 65 1 155441.0372
NX_P08581-2
2 65 1 157610.1073
NX_P08581-3
1 35 0 85689.6081
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1039152,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
2 EBI-1039152,EBI-3929549 SOCS6  
  .negative regulation of T cell activation
.negative regulation of JAK-STAT cascade
.regulation of growth
  + 6 more...
.protein kinase inhibitor activity .cytoplasm
.immunological synapse
3 EBI-1039152,EBI-3923013 SH2D1B  
  .positive regulation of innate immune response
.positive regulation of natural killer cell mediated immunity
.leukocyte activation involved in immune response
.protein binding, bridging .intracellular
4 EBI-1039152,EBI-722004 PLXNB2  
  .regulation of neuron migration
.semaphorin-plexin signaling pathway
.positive regulation of axonogenesis
  + 6 more...
.semaphorin receptor activity .extracellular exosome
.cell surface
.integral component of plasma membrane
.intracellular
5 EBI-1039152,EBI-1384248 INPPL1  
  .ruffle assembly
.phosphatidylinositol dephosphorylation
.small molecule metabolic process
  + 13 more...
.SH2 domain binding
.hydrolase activity
.filopodium
.lamellipodium
.plasma membrane
  + 4 more...
6 EBI-1039152,EBI-1111488 PLXNB1  
  .semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
.semaphorin-plexin signaling pathway
.regulation of cytoskeleton organization
  + 12 more...
.GTPase activating protein binding
.semaphorin receptor binding
.semaphorin receptor activity
  + 2 more...
.integral component of plasma membrane
.plasma membrane
.intracellular
  + 2 more...
7 EBI-1039152,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
8 EBI-1039152,EBI-6983382 SH2D1A  
  .positive regulation of natural killer cell mediated cytotoxicity
.positive regulation of signal transduction
.cell-cell signaling
  + 2 more...
.SH3/SH2 adaptor activity .cytoplasm
9 EBI-1039152,EBI-970130 SOCS5  
  .negative regulation of JAK-STAT cascade
.negative regulation of T-helper 2 cell differentiation
.positive regulation of T-helper 1 cell differentiation
  + 9 more...
.receptor tyrosine kinase binding
.protein kinase inhibitor activity
.cytoplasm
10 EBI-1039152,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
11 EBI-1039152,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
12 EBI-1039152,EBI-515331 YES1  
  .cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
13 EBI-1039152,EBI-79452 LYN  
  .positive regulation of dendritic cell apoptotic process
.negative regulation of intracellular signal transduction
.dendritic cell differentiation
  + 83 more...
.ion channel binding
.glycosphingolipid binding
.enzyme binding
  + 5 more...
.extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 11 more...
14 EBI-1039152,EBI-1383732 FGR  
  .cellular response to peptide hormone stimulus
.defense response to Gram-positive bacterium
.regulation of phagocytosis
  + 22 more...
.Fc-gamma receptor I complex binding
.immunoglobulin receptor binding
.protein kinase binding
  + 4 more...
.extracellular exosome
.ruffle membrane
.extrinsic component of cytoplasmic side of plasma membrane
  + 5 more...
15 EBI-1039152,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
16 EBI-1039152,EBI-1039104 HGF  
  .positive regulation of DNA biosynthetic process
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of hydrogen peroxide-mediated programmed cell death
  + 25 more...
.identical protein binding
.chemoattractant activity
.growth factor activity
.catalytic activity
.platelet alpha granule lumen
.membrane
.extracellular space
.extracellular region
17 EBI-1039152,EBI-2804728 MUC1  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.positive regulation of histone H4 acetylation
.cellular protein metabolic process
  + 9 more...
.transcription cofactor activity
.p53 binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.extracellular exosome
.vesicle
.apical plasma membrane
  + 4 more...
18 EBI-1039152,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
19 EBI-1039152,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
20 EBI-1039152,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
21 EBI-1039152,EBI-1026476 RASA1  
  .regulation of RNA metabolic process
.blood vessel morphogenesis
.ephrin receptor signaling pathway
  + 14 more...
.GTPase binding
.potassium channel inhibitor activity
.receptor binding
  + 2 more...
.intrinsic component of the cytoplasmic side of the plasma membrane
.cytosol
.cytoplasm
.ruffle
22 EBI-1039152,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
23 EBI-1039152,EBI-1265766 PTPRB  
  .peptidyl-tyrosine dephosphorylation
.dephosphorylation
.phosphate-containing compound metabolic process
  + 2 more...
.transmembrane receptor protein tyrosine phosphatase activity .receptor complex
.integral component of plasma membrane
24 EBI-1039152,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
25 EBI-1039152,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
26 EBI-1039152,EBI-1005487 KDR  
  .positive regulation of vasculogenesis
.negative regulation of endothelial cell apoptotic process
.positive regulation of ERK1 and ERK2 cascade
  + 39 more...
.Hsp90 protein binding
.vascular endothelial growth factor binding
.growth factor binding
  + 6 more...
.sorting endosome
.membrane raft
.cell junction
  + 10 more...
27 EBI-1039152,EBI-1383480 TEC  
  .B cell receptor signaling pathway
.T cell receptor signaling pathway
.positive regulation of peptidyl-tyrosine phosphorylation
  + 12 more...
.metal ion binding
.phospholipid binding
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cell-cell junction
.cytoskeleton
.cytosol
28 EBI-1039152,EBI-1211276 ZAP70  
  .T cell migration
.T cell aggregation
.T cell receptor signaling pathway
  + 19 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.T cell receptor complex
.extrinsic component of cytoplasmic side of plasma membrane
.cell-cell junction
  + 4 more...
29 EBI-1039152,EBI-78302 SYK  
  .regulation of platelet aggregation
.regulation of arachidonic acid secretion
.cellular response to molecule of fungal origin
  + 49 more...
.ATP binding
.integrin binding
.receptor signaling protein tyrosine kinase activity
  + 4 more...
.protein complex
.T cell receptor complex
.early phagosome
  + 6 more...
30 EBI-1039152,EBI-7256023 SHC2  
  .neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
.insulin receptor signaling pathway
  + 3 more...
.receptor tyrosine kinase binding
.protein kinase binding
.plasma membrane
.cytosol
31 EBI-1039152,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
32 EBI-1039152,EBI-2264500 PTPRJ  
  .negative regulation of receptor activity
.contact inhibition
.negative regulation of protein kinase B signaling
  + 21 more...
.delta-catenin binding
.mitogen-activated protein kinase binding
.gamma-catenin binding
  + 5 more...
.extracellular exosome
.ruffle membrane
.cell junction
  + 6 more...
33 EBI-1039152,EBI-4402156 SHB  
  .vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .plasma membrane
.cytosol
34 EBI-1039152,EBI-949753 TENC1  
  .multicellular organismal homeostasis
.intracellular signal transduction
.multicellular organism growth
  + 5 more...
.metal ion binding
.kinase binding
.phosphoprotein phosphatase activity
.focal adhesion
.plasma membrane
35 EBI-1039152,EBI-1220488 TNS3  
  .lung alveolus development
.cell migration
.positive regulation of cell proliferation
.N/A .focal adhesion
.cytoplasm
36 EBI-1039152,EBI-9453524 SHC4  
  .stem cell differentiation
.intracellular signal transduction
.regulation of gene expression
  + 3 more...
.receptor tyrosine kinase binding
.protein kinase binding
.postsynaptic membrane
.cell junction
.plasma membrane
37 EBI-1039152,EBI-745980 SH2D3C  
  .positive regulation of signal transduction
.small GTPase mediated signal transduction
.JNK cascade
.guanyl-nucleotide exchange factor activity
.SH3/SH2 adaptor activity
.membrane
.cytoplasm
38 EBI-1039152,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
39 EBI-1039152,EBI-3952284 DNAJA3  
  .skeletal muscle acetylcholine-gated channel clustering
.negative regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 23 more...
.chaperone binding
.unfolded protein binding
.NF-kappaB binding
  + 5 more...
.postsynaptic membrane
.intracellular membrane-bounded organelle
.mitochondrial nucleoid
  + 8 more...
40 EBI-1039152,EBI-4402781 SHD  
  .N/A .N/A .N/A
41 EBI-1039152,EBI-1222854 SLA2  
  .negative regulation of B cell activation
.antigen receptor-mediated signaling pathway
.negative regulation of calcium-mediated signaling
  + 6 more...
.protein N-terminus binding
.SH3/SH2 adaptor activity
.cytoplasmic membrane-bounded vesicle
.endosome membrane
.plasma membrane
  + 2 more...
42 EBI-1039152,EBI-3389814 TNS1  
  .fibroblast migration
.cell-substrate junction assembly
.poly(A) RNA binding .cell surface
.focal adhesion
.cytoskeleton
.cytoplasm
43 EBI-1039152,EBI-490630 SH2D2A  
  .vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .cytosol
.cytoplasm
44 EBI-1039152,EBI-297568 VAV3  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.B cell receptor signaling pathway
  + 22 more...
.metal ion binding
.Rac guanyl-nucleotide exchange factor activity
.GTPase activator activity
  + 2 more...
.extracellular exosome
.plasma membrane
.cytosol
45 EBI-1039152,EBI-311073 PLXNB3  
  .semaphorin-plexin signaling pathway
.cell chemotaxis
.positive chemotaxis
  + 6 more...
.protein domain specific binding
.semaphorin receptor activity
.integral component of membrane
.plasma membrane
.intracellular
46 EBI-1039152,EBI-6083058 STAP1  
  .positive regulation of actin cytoskeleton reorganization
.positive regulation of non-membrane spanning protein tyrosine kinase activity
.positive regulation of microglial cell activation
  + 10 more...
.protein kinase binding
.phospholipid binding
.SH3/SH2 adaptor activity
  + 2 more...
.protein complex
.mitochondrion
.cytoplasm
.nucleus
47 EBI-1039152,EBI-7879749 SH2B3  
  .intracellular signal transduction
.embryonic hemopoiesis
.cell differentiation
.blood coagulation
.phosphate ion binding
.signaling adaptor activity
.signal transducer activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites401
bladder33
bone83
bone marrow61
brain14
cervix41
connective tissue40
ear186
embryonic tissue4
esophagus248
eye43
heart11
intestine125
kidney109
liver68
lung86
lymph node55
mammary gland39
mouth90
muscle56
ovary29
placenta38
prostate15
salivary gland98
skin56
spleen37
stomach62
testis6
thymus37
thyroid128
trachea231
uterus60
vascular77
Health State
TissuesTPM*
normal48
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma108
colorectal tumor204
esophageal tumor289
gastrointestinal tumor185
germ cell tumor15
glioma18
head and neck tumor82
kidney tumor43
leukemia10
liver tumor124
lung tumor87
non-neoplasia20
ovarian tumor39
prostate cancer19
skin tumor39
soft tissue/muscle tissue tumor31
uterine tumor66
Developmental Stage
TissuesTPM*
adult56
embryoid body14
fetus100
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.9
appendix4.3
bone marrow3.7
cerebral cortex6.1
colon11.6
duodenum6.1
esophagus6.3
gallbladder14.9
heart muscle5.4
kidney18.6
liver26
lung20.8
lymph node2.7
pancreas2.9
placenta29.1
prostate5.5
salivary gland4.2
skin7.2
small intestine8.2
spleen6.4
stomach16.2
thyroid gland20.1
urinary bladder22.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#114550, phenotype) Hepatocellular carcinomaOMIM
2(*164860, gene) Met protooncogene; METOMIM
3(#605074, phenotype) Renal cell carcinoma, papillary, 1; RCCP1OMIM


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