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> Protein (NX_P08621)
Protein (NX_P08621)
Protein
Gene SymbolSNRNP70 to neXtProt (NX_P08621)
DescriptionU1 small nuclear ribonucleoprotein 70 kDa
Chromosome19
Location19q13.33 (49588676 ~ 49611862) to Ensembl
Sequene Features : Isoforms 4, Variants 36, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of mRNA splicing, via spliceosome
.regulation of RNA splicing
.gene expression
  + 3 more...
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.nuclear speck
.U1 snRNP
.spliceosomal complex
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 36 14
2014-09-19protein level
4 27 14
2014-05-27protein level
4 27 14
2014-02-25protein level
4 26 13
2013-12-09protein level
4 22 14
2013-11-01protein level
4 22 10
2013-09-12protein level
4 22 10
2013-08-17protein level
4 22 10
2013-07-15protein level
4 13 7
2013-06-11protein level
4 13 7
2013-02-12protein level
4 3 37
2012-12-20protein level
4 4 23
2012-10-30protein level
4 4 23
2012-10-07protein level
4 4 8
2012-08-24protein level
4 4 8
2012-07-28protein level
4 4 8
2012-06-08protein level
4 4 8
2012-05-07protein level
4 2 8
2012-04-10protein level
4 2 8
2012-01-13protein level
4 1 8
2011-12-20protein level
4 1 8
2011-11-11protein level
4 1 8
2011-08-23protein level
4 1 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P08621-1
0 14 0 51525.6791
NX_P08621-2
0 13 0 50587.1733
NX_P08621-3
1 8 0 19777.8853
NX_P08621-4
2 6 0 39167.5765
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1049228,EBI-750020 CLK2  
  .protein autophosphorylation
.negative regulation of gluconeogenesis
.regulation of RNA splicing
  + 3 more...
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
.protein serine/threonine kinase activity
.nuclear speck
.nucleoplasm
.nucleus
2 EBI-1049228,EBI-593303 SRPK2  
  .regulation of mRNA splicing, via spliceosome
.positive regulation of cell cycle
.innate immune response
  + 12 more...
.14-3-3 protein binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland91
ascites803
bladder234
blood122
bone139
bone marrow20
brain462
cervix288
connective tissue107
embryonic tissue333
esophagus248
eye148
heart178
intestine189
kidney194
larynx42
liver116
lung146
lymph180
lymph node111
mammary gland264
mouth211
muscle47
nerve386
ovary305
pancreas93
parathyroid97
pharynx49
pituitary gland60
placenta236
prostate131
salivary gland98
skin218
spleen468
stomach209
testis112
thymus501
thyroid322
tonsil235
trachea328
umbilical cord145
uterus581
vascular58
Health State
TissuesTPM*
normal256
adrenal tumor79
bladder carcinoma341
breast (mammary gland) tumor354
cervical tumor231
chondrosarcoma120
colorectal tumor168
esophageal tumor289
gastrointestinal tumor464
germ cell tumor182
glioma167
head and neck tumor209
kidney tumor232
leukemia190
liver tumor104
lung tumor282
lymphoma277
non-neoplasia258
ovarian tumor236
pancreatic tumor104
primitive neuroectodermal tumor of the CNS275
prostate cancer57
retinoblastoma301
skin tumor295
soft tissue/muscle tissue tumor103
uterine tumor288
Developmental Stage
TissuesTPM*
adult189
embryoid body300
blastocyst341
neonate128
fetus186
infant170
juvenile377
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue105.3
adrenal gland121.4
appendix120.9
bone marrow87.4
cerebral cortex80.9
colon70.4
duodenum115.1
esophagus49.9
gallbladder73.5
heart muscle56.9
kidney85.3
liver52.7
lung99.3
lymph node138.4
ovary130.9
pancreas76.9
placenta90.3
prostate171.5
salivary gland146.6
skin142.5
small intestine128.5
spleen183.4
stomach117.8
testis99
thyroid gland69.1
urinary bladder67.4
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*180740, gene) Small nuclear ribonucleoprotein, 70-kd; SNRP70OMIM


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