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> Protein (NX_P08631)
Protein (NX_P08631)
Protein
Gene SymbolHCK to neXtProt (NX_P08631)
DescriptionTyrosine-protein kinase HCK
Chromosome20
Location20q11.21 (30639991 ~ 30689659) to Ensembl
Sequene Features : Isoforms 4, Variants 108, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 108 10
2014-09-19protein level
4 81 10
2014-05-27protein level
4 81 11
2014-02-25protein level
4 80 11
2013-12-09protein level
4 70 11
2013-11-01protein level
4 64 9
2013-09-12protein level
4 64 9
2013-08-17protein level
4 64 9
2013-07-15protein level
4 46 9
2013-06-11protein level
4 46 9
2013-02-12protein level
4 28 51
2012-12-20protein level
4 28 51
2012-10-30protein level
4 31 51
2012-10-07protein level
4 31 14
2012-08-24protein level
4 25 14
2012-07-28protein level
4 25 14
2012-06-08protein level
4 19 14
2012-05-07protein level
4 19 14
2012-04-10protein level
4 19 14
2012-01-13protein level
4 19 15
2011-12-20protein level
4 20 15
2011-11-11protein level
4 14 16
2011-08-23protein level
2 12 16
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P08631-1
0 22 4 59561.5074
NX_P08631-2
0 21 4 57275.545
NX_P08631-3
0 21 4 57204.5081
NX_P08631-4
0 22 4 59490.4705
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-346340,EBI-346356 WIPF1  
  .response to other organism
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.profilin binding
.actin binding
.cytoplasmic membrane-bounded vesicle
.actin cytoskeleton
.actin filament
  + 2 more...
2 EBI-9834454,EBI-725515 FRS3  
  .fibroblast growth factor receptor signaling pathway
.signal transduction
.fibroblast growth factor receptor binding .plasma membrane
3 EBI-346340,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
4 EBI-346340,EBI-79934 ALOX5  
  .lipoxin metabolic process
.small molecule metabolic process
.lipoxygenase pathway
  + 4 more...
.iron ion binding
.arachidonate 5-lipoxygenase activity
.nuclear membrane
.nuclear matrix
.cytosol
  + 3 more...
5 EBI-346340,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
6 EBI-346340,EBI-1026718 FLT1  
  .embryonic morphogenesis
.blood vessel morphogenesis
.vascular endothelial growth factor receptor signaling pathway
  + 20 more...
.placental growth factor-activated receptor activity
.VEGF-B-activated receptor activity
.VEGF-A-activated receptor activity
  + 4 more...
.receptor complex
.focal adhesion
.integral component of plasma membrane
  + 3 more...
7 EBI-346340,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
8 EBI-346340,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
9 EBI-9834454,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
10 EBI-346340,EBI-2609540 PIK3CB  
  .regulation of clathrin-mediated endocytosis
.platelet aggregation
.cell chemotaxis
  + 34 more...
.phosphatidylinositol-4,5-bisphosphate 3-kinase activity
.1-phosphatidylinositol-4-phosphate 3-kinase activity
.phosphatidylinositol 3-kinase activity
  + 2 more...
.phosphatidylinositol 3-kinase complex
.plasma membrane
.cytosol
  + 2 more...
11 EBI-346340,EBI-346375 WAS  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of cell motility
.T cell receptor signaling pathway
  + 15 more...
.phospholipase binding
.identical protein binding
.GTPase regulator activity
  + 2 more...
.extracellular exosome
.actin cytoskeleton
.vesicle membrane
  + 2 more...
12 EBI-346340,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
13 EBI-9834454,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
14 EBI-346340,EBI-1364 KHDRBS1  
  .positive regulation of RNA export from nucleus
.regulation of RNA export from nucleus
.positive regulation of translational initiation
  + 8 more...
.poly(A) RNA binding
.identical protein binding
.poly(U) RNA binding
  + 4 more...
.Grb2-Sos complex
.membrane
.cytoplasm
  + 2 more...
15 EBI-346340,EBI-297487 SOS1  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 16 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.Ras guanyl-nucleotide exchange factor activity
.DNA binding
.neuronal cell body
.postsynaptic density
.plasma membrane
.cytosol
16 EBI-346340,EBI-1045887 PAK2  
  .negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of protein tyrosine kinase activity
  + 30 more...
.Rac GTPase binding
.identical protein binding
.protein tyrosine kinase activator activity
  + 4 more...
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 2 more...
17 EBI-346340,EBI-77818 ADAM15  
  .negative regulation of receptor binding
.protein kinase C signaling
.cardiac epithelial to mesenchymal transition
  + 11 more...
.SH3 domain binding
.zinc ion binding
.metallopeptidase activity
  + 2 more...
.extracellular exosome
.cell projection
.integral component of membrane
  + 4 more...
18 EBI-346340,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
19 EBI-346340,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
20 EBI-346340,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
21 EBI-9834454,EBI-3867416 OLIG1  
  .neuron fate commitment
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .nucleus
22 EBI-346340,EBI-310624 PDCD6IP  
  .positive regulation of extracellular exosome assembly
.regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
  + 9 more...
.calcium-dependent protein binding
.protein homodimerization activity
.proteinase activated receptor binding
.endoplasmic reticulum exit site
.extracellular exosome
.melanosome
  + 7 more...
23 EBI-346340,EBI-346417 ELMO1  
  .regulation of defense response to virus by virus
.vascular endothelial growth factor receptor signaling pathway
.innate immune response
  + 7 more...
.SH3 domain binding .membrane
.plasma membrane
.cytoskeleton
  + 2 more...
24 EBI-9834454,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
25 EBI-346340,EBI-349832 GOPC  
  .protein homooligomerization
.regulation of catalytic activity
.apical protein localization
  + 6 more...
.ion channel binding .postsynaptic membrane
.protein complex
.Golgi-associated vesicle membrane
  + 9 more...
26 EBI-346340,EBI-346622 ASAP1  
  .cilium morphogenesis
.organelle organization
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.GTPase activator activity
.membrane
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood286
brain5
cervix20
connective tissue13
esophagus49
eye19
intestine17
kidney18
lung59
lymph90
lymph node44
mammary gland6
ovary9
pancreas14
placenta28
prostate10
skin18
spleen168
stomach10
testis2
thymus50
tonsil58
umbilical cord72
uterus25
Health State
TissuesTPM*
normal33
bladder carcinoma113
cervical tumor28
esophageal tumor57
germ cell tumor15
leukemia95
lung tumor9
lymphoma83
non-neoplasia41
ovarian tumor13
pancreatic tumor19
skin tumor7
Developmental Stage
TissuesTPM*
adult22
neonate354
fetus12
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21
adrenal gland9.1
appendix87.3
bone marrow32.9
cerebral cortex5.8
colon12.8
duodenum13.1
esophagus6
gallbladder15.3
heart muscle3.4
kidney2.6
liver6.8
lung33.7
lymph node37
ovary2.3
pancreas1.9
placenta16.9
prostate2.4
salivary gland3.3
skin5.2
small intestine15.4
spleen69.4
stomach7.2
testis3.5
thyroid gland2.9
urinary bladder24.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*142370, gene) Hemopoietic cell kinase; HCKOMIM


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