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> Protein (NX_P08670)
Protein (NX_P08670)
Protein
Gene SymbolVIM to neXtProt (NX_P08670)
DescriptionVimentin
Chromosome10
Location10p13 (17270258 ~ 17279592) to Ensembl
Sequene Features : Isoforms 1, Variants 88, PTMs 83 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.lens fiber cell development
.SMAD protein signal transduction
.Bergmann glial cell differentiation
  + 10 more...
.keratin filament binding
.scaffold protein binding
.identical protein binding
  + 5 more...
.extracellular exosome
.intermediate filament cytoskeleton
.neuron projection
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 88 83
2014-09-19protein level
1 68 83
2014-05-27protein level
1 68 86
2014-02-25protein level
1 67 78
2013-12-09protein level
1 59 79
2013-11-01protein level
1 58 79
2013-09-12protein level
1 57 76
2013-08-17protein level
1 57 75
2013-07-15protein level
1 43 58
2013-06-11protein level
1 43 58
2013-02-12protein level
1 23 58
2012-12-20protein level
1 23 58
2012-10-30protein level
1 26 58
2012-10-07protein level
1 26 58
2012-08-24protein level
1 24 58
2012-07-28protein level
1 24 58
2012-06-08protein level
1 37 58
2012-05-07protein level
1 27 58
2012-04-10protein level
1 27 58
2012-01-13protein level
1 25 58
2011-12-20protein level
1 25 58
2011-11-11protein level
1 25 54
2011-08-23protein level
1 25 52
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P08670-1
23 0 6 53618.9235
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-353844,EBI-368321 PPL  
  .keratinization .structural constituent of cytoskeleton .extracellular exosome
.desmosome
.plasma membrane
  + 3 more...
2 EBI-353844,EBI-473199 KAT7  
  .histone H4-K12 acetylation
.histone H4-K8 acetylation
.histone H4-K5 acetylation
  + 5 more...
.zinc ion binding
.histone acetyltransferase activity
.sequence-specific DNA binding transcription factor activity
.cytoplasm
.nucleoplasm
.histone acetyltransferase complex
3 EBI-353844,EBI-727384 TRIM16  
  .response to growth hormone
.positive regulation of interleukin-1 beta secretion
.positive regulation of retinoic acid receptor signaling pathway
  + 6 more...
.NACHT domain binding
.interleukin-1 binding
.zinc ion binding
.DNA binding
.PML body
.cytoplasm
4 EBI-353844,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
5 EBI-353844,EBI-296058 AKT2  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of cell motility
.positive regulation of protein targeting to membrane
  + 24 more...
.kinase activity
.ATP binding
.protein serine/threonine kinase activity
.ruffle membrane
.cell cortex
.plasma membrane
  + 3 more...
6 EBI-353844,EBI-742094 KRT20  
  .regulation of protein secretion
.intermediate filament organization
.cellular response to stress
.apoptotic process
.structural constituent of cytoskeleton .intermediate filament
.cytoplasm
7 EBI-353844,EBI-954531 RAD23B  
  .proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
.spermatogenesis
  + 4 more...
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.XPC complex
.cytoplasm
.nucleoplasm
  + 2 more...
8 EBI-353844,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
9 EBI-353844,EBI-9087684 PKP1  
  .intermediate filament bundle assembly
.single organismal cell-cell adhesion
.programmed cell death
  + 5 more...
.structural constituent of epidermis
.intermediate filament binding
.lamin binding
.signal transducer activity
.extracellular exosome
.intracellular membrane-bounded organelle
.desmosome
  + 4 more...
10 EBI-353844,EBI-473101 CRMP1  
  .axon guidance
.nervous system development
.nucleobase-containing compound metabolic process
.microtubule cytoskeleton organization
.hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds .neuronal cell body
.dendrite
.cytosol
  + 3 more...
11 EBI-353844,EBI-602382 PKN1  
  .regulation of cell motility
.histone H3-T11 phosphorylation
.epithelial cell migration
  + 7 more...
.androgen receptor binding
.Rac GTPase binding
.histone deacetylase binding
  + 10 more...
.cleavage furrow
.midbody
.cytoplasmic membrane-bounded vesicle
  + 6 more...
12 EBI-353844,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
13 EBI-353844,EBI-6083685 BCAS3  
  .positive regulation of actin cytoskeleton reorganization
.regulation of establishment of cell polarity
.activation of GTPase activity
  + 16 more...
.beta-tubulin binding
.histone binding
.nuclear hormone receptor binding
  + 4 more...
.cell periphery
.intermediate filament cytoskeleton
.transcriptionally active chromatin
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue1165
adrenal gland850
ascites25
bladder133
blood899
bone3141
bone marrow779
brain600
cervix1031
connective tissue2126
ear4347
embryonic tissue2207
esophagus496
eye1173
heart915
intestine400
kidney607
larynx127
liver1013
lung806
lymph67
lymph node245
mammary gland1302
mouth90
muscle300
nerve2381
ovary591
pancreas688
parathyroid48
pharynx171
pituitary gland665
placenta710
prostate195
salivary gland394
skin1546
spleen599
stomach762
testis346
thymus401
thyroid2103
tonsil58
trachea135
umbilical cord3632
uterus1645
vascular1742
Health State
TissuesTPM*
adrenal tumor1185
bladder carcinoma227
breast (mammary gland) tumor1256
cervical tumor1159
chondrosarcoma3066
colorectal tumor195
esophageal tumor521
gastrointestinal tumor497
germ cell tumor402
glioma932
head and neck tumor478
kidney tumor711
leukemia740
liver tumor1770
lung tumor1041
lymphoma263
non-neoplasia1283
ovarian tumor406
pancreatic tumor1219
primitive neuroectodermal tumor of the CNS637
prostate cancer96
retinoblastoma236
skin tumor1770
soft tissue/muscle tissue tumor1540
uterine tumor1997
Developmental Stage
TissuesTPM*
adult860
embryoid body1200
blastocyst699
neonate2510
fetus1001
infant425
juvenile1079
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1287.5
adrenal gland326.3
appendix560.3
bone marrow817.7
cerebral cortex206.2
colon316.7
duodenum182.3
esophagus395.4
gallbladder848.6
heart muscle395.6
kidney165.1
liver105.4
lung793
lymph node671.5
ovary1928.9
pancreas166.4
placenta671.8
prostate266.1
salivary gland198.4
skin445.2
small intestine229.6
spleen641.3
stomach246.6
testis276.4
thyroid gland824
urinary bladder622.4
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
bone marrowHigh
breastHigh
bronchusLow
cerebral cortexHigh
cervix, uterineMedium
colonHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
fallopian tubeHigh
hippocampusLow
kidneyHigh
lateral ventricleMedium
liverLow
lungHigh
lymph nodeHigh
nasopharynxLow
ovaryHigh
pancreasMedium
seminal vesicleHigh
skin 1High
soft tissue 1High
soft tissue 2High
spleenHigh
testisHigh
thyroid glandHigh
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(%116300, phenotype) Cataract, nuclear diffuse nonprogressiveOMIM
2(+193060, gene/phenotype) Vimentin; VIMOMIM


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