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> Protein (NX_P08727)
Protein (NX_P08727)
Protein
Gene SymbolKRT19 to neXtProt (NX_P08727)
DescriptionKeratin, type I cytoskeletal 19
Chromosome17
Location17q21.2 (39679869 ~ 39684560) to Ensembl
Sequene Features : Isoforms 1, Variants 53, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 53 12
2014-09-19protein level
1 43 12
2014-05-27protein level
1 43 13
2014-02-25protein level
1 43 7
2013-12-09protein level
1 35 7
2013-11-01protein level
1 34 7
2013-09-12protein level
1 34 7
2013-08-17protein level
1 34 7
2013-07-15protein level
1 20 11
2013-06-11protein level
1 20 11
2013-02-12protein level
1 12 10
2012-12-20protein level
1 12 10
2012-10-30protein level
1 12 10
2012-10-07protein level
1 12 10
2012-08-24protein level
1 11 10
2012-07-28protein level
1 11 10
2012-06-08protein level
1 14 10
2012-05-07protein level
1 14 10
2012-04-10protein level
1 14 10
2012-01-13protein level
1 11 10
2011-12-20protein level
1 11 9
2011-11-11protein level
1 11 9
2011-08-23protein level
1 11 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P08727-1
17 0 7 44078.9954
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742756,EBI-1055079 POLR1C  
  .negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
2 EBI-742756,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
3 EBI-742756,EBI-295827 DMD  
  .positive regulation of sodium ion transmembrane transporter activity
.negative regulation of peptidyl-cysteine S-nitrosylation
.regulation of voltage-gated calcium channel activity
  + 23 more...
.nitric-oxide synthase binding
.vinculin binding
.myosin binding
  + 5 more...
.postsynaptic membrane
.synapse
.membrane raft
  + 15 more...
4 EBI-742756,EBI-1247312 KRT2  
  .keratinocyte migration
.keratinocyte proliferation
.keratinocyte activation
  + 2 more...
.structural constituent of cytoskeleton .extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 6 more...
5 EBI-742756,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
6 EBI-742756,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
7 EBI-742756,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
8 EBI-742756,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
9 EBI-742756,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
10 EBI-742756,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
11 EBI-742756,EBI-741626 FAM124B  
  .N/A .N/A .N/A
12 EBI-742756,EBI-301024 EIF4ENIF1  
  .N/A .poly(A) RNA binding
.protein transporter activity
.intracellular membrane-bounded organelle
.nuclear speck
.PML body
  + 4 more...
13 EBI-742756,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
14 EBI-742756,EBI-3258000 TBC1D7  
  .negative regulation of cilium assembly
.activation of GTPase activity
.response to growth factor
  + 2 more...
.Rab GTPase binding
.GTPase activator activity
.ciliary basal body
.cytoplasmic vesicle
.cytoplasmic membrane-bounded vesicle
15 EBI-742756,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
16 EBI-742756,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland30
ascites652
bladder569
blood16
bone13
brain51
connective tissue60
embryonic tissue413
esophagus545
eye565
heart44
intestine797
kidney260
larynx340
liver433
lung537
lymph45
lymph node222
mammary gland1421
mouth211
muscle9
ovary709
pancreas1471
pharynx368
placenta745
prostate495
salivary gland49
skin9
stomach543
testis4
thymus75
thyroid300
uterus249
Health State
TissuesTPM*
normal143
bladder carcinoma625
breast (mammary gland) tumor1557
chondrosarcoma60
colorectal tumor1182
esophageal tumor637
gastrointestinal tumor708
germ cell tumor615
glioma438
head and neck tumor209
kidney tumor275
leukemia21
liver tumor833
lung tumor1381
lymphoma27
non-neoplasia341
ovarian tumor879
pancreatic tumor2923
primitive neuroectodermal tumor of the CNS23
prostate cancer597
retinoblastoma86
soft tissue/muscle tissue tumor71
uterine tumor577
Developmental Stage
TissuesTPM*
adult320
embryoid body914
blastocyst146
fetus26
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.7
adrenal gland19.9
appendix58
cerebral cortex1
colon393.8
duodenum263.6
esophagus264.5
gallbladder307.8
heart muscle2.1
kidney76.9
liver4.2
lung145.3
ovary50.2
pancreas18.4
placenta193.1
prostate74.2
salivary gland245.3
skin1.1
small intestine291.8
stomach479.9
testis4.6
thyroid gland7.6
urinary bladder474.7
Tissues
TissuesExpression level
appendixHigh
breastHigh
bronchusHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
kidneyHigh
liverHigh
lungHigh
nasopharynxHigh
oral mucosaLow
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skin 2Low
small intestineHigh
stomach 1High
stomach 2High
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*148020, gene) Keratin 19; KRT19OMIM


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