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> Protein (NX_P09429)
Protein (NX_P09429)
Protein
Gene SymbolHMGB1 to neXtProt (NX_P09429)
DescriptionHigh mobility group protein B1
Chromosome13
Location13q12.3 (31032884 ~ 31191734) to Ensembl
Sequene Features : Isoforms 1, Variants 26, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of apoptotic cell clearance
.DNA ligation involved in DNA repair
.positive chemotaxis
  + 23 more...
.repressing transcription factor binding
.RAGE receptor binding
.poly(A) RNA binding
  + 9 more...
.cell surface
.nucleoplasm
.nucleus
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 26 10
2014-09-19protein level
1 21 10
2014-05-27protein level
1 21 15
2014-02-25protein level
1 20 12
2013-12-09protein level
1 18 12
2013-11-01protein level
1 17 9
2013-09-12protein level
1 17 9
2013-08-17protein level
1 17 9
2013-07-15protein level
1 12 5
2013-06-11protein level
1 12 5
2013-02-12protein level
1 8 6
2012-12-20protein level
1 7 6
2012-10-30protein level
1 10 6
2012-10-07protein level
1 10 6
2012-08-24protein level
1 8 6
2012-07-28protein level
1 8 6
2012-06-08protein level
1 10 6
2012-05-07protein level
1 10 6
2012-04-10protein level
1 10 6
2012-01-13protein level
1 13 6
2011-12-20protein level
1 13 6
2011-11-11protein level
1 13 6
2011-08-23protein level
1 13 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P09429-1
5 0 1 24878.0918
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-389432,EBI-949378 BECN1  
  .positive regulation of mitochondrion degradation
.positive regulation of attachment of mitotic spindle microtubules to kinetochore
.activation of mitophagy in response to mitochondrial depolarization
  + 28 more...
.phosphatidylinositol 3-kinase binding .phagocytic vesicle
.phosphatidylinositol 3-kinase complex, class III
.phosphatidylinositol 3-kinase complex, class III, type II
  + 12 more...
2 EBI-389432,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland607
ascites75
bladder66
blood24
bone83
bone marrow636
brain24
cervix41
connective tissue60
ear496
embryonic tissue89
esophagus248
eye28
heart11
intestine30
kidney4
larynx127
liver38
lung38
lymph22
lymph node11
mammary gland52
muscle37
nerve193
ovary9
pancreas46
parathyroid194
pharynx171
pituitary gland242
placenta45
prostate21
salivary gland98
skin28
spleen37
stomach125
testis13
thymus50
tonsil58
trachea19
umbilical cord145
uterus21
vascular19
Health State
TissuesTPM*
normal24
adrenal tumor474
bladder carcinoma170
breast (mammary gland) tumor75
cervical tumor57
chondrosarcoma108
colorectal tumor17
esophageal tumor115
gastrointestinal tumor67
germ cell tumor68
glioma9
head and neck tumor7
kidney tumor14
leukemia42
liver tumor62
lung tumor58
lymphoma41
non-neoplasia10
ovarian tumor13
pancreatic tumor104
primitive neuroectodermal tumor of the CNS110
prostate cancer77
retinoblastoma452
skin tumor287
soft tissue/muscle tissue tumor143
uterine tumor33
Developmental Stage
TissuesTPM*
adult31
embryoid body71
blastocyst65
neonate289
fetus23
infant595
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue113.6
adrenal gland104.2
appendix139.6
bone marrow248.4
cerebral cortex102.8
colon124.4
duodenum102.3
esophagus103.2
gallbladder99
heart muscle70.1
kidney90.8
liver78.3
lung112.2
lymph node220.4
ovary108.4
pancreas35
placenta84.4
prostate120.4
salivary gland68.5
skin92.5
small intestine115.8
spleen119.3
stomach97.4
testis65.8
thyroid gland109
urinary bladder112.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*163905, gene) High mobility group box 1; HMGB1OMIM


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