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> Protein (NX_P09619)
Protein (NX_P09619)
Protein
Gene SymbolPDGFRB to neXtProt (NX_P09619)
DescriptionPlatelet-derived growth factor receptor beta
Chromosome5
Location5q32 (149493400 ~ 149535435) to Ensembl
Sequene Features : Isoforms 2, Variants 186, PTMs 34 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
.positive regulation of calcium ion import
  + 60 more...
.platelet-derived growth factor binding
.vascular endothelial growth factor binding
.protein kinase binding
  + 7 more...
.extracellular exosome
.lysosomal lumen
.intrinsic component of plasma membrane
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 186 34
2014-09-19protein level
1 139 34
2014-05-27protein level
1 139 34
2014-02-25protein level
1 139 34
2013-12-09protein level
1 116 34
2013-11-01protein level
1 110 34
2013-09-12protein level
1 108 34
2013-08-17protein level
1 108 34
2013-07-15protein level
1 75 34
2013-06-11protein level
1 75 34
2013-02-12protein level
1 47 33
2012-12-20protein level
1 46 33
2012-10-30protein level
1 50 33
2012-10-07protein level
1 50 33
2012-08-24protein level
1 36 33
2012-07-28protein level
1 36 33
2012-06-08protein level
1 50 33
2012-05-07protein level
1 47 33
2012-04-10protein level
1 47 33
2012-01-13protein level
1 36 33
2011-12-20protein level
1 36 33
2011-11-11protein level
1 36 33
2011-08-23protein level
1 33 28
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P09619-1
33 13 2 123889.0997
NX_P09619-2
2 13 0 37387.6945
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-641237,EBI-349787 SLC9A3R1  
  .positive regulation of intrinsic apoptotic signaling pathway
.renal phosphate ion absorption
.negative regulation of ERK1 and ERK2 cascade
  + 21 more...
.growth factor receptor binding
.protein self-association
.beta-2 adrenergic receptor binding
  + 5 more...
.sperm midpiece
.cell periphery
.extracellular exosome
  + 15 more...
2 EBI-641237,EBI-1554925 PDGFB  
  .positive regulation of metanephric mesenchymal cell migration
.positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
  + 74 more...
.platelet-derived growth factor binding
.protein heterodimerization activity
.protein homodimerization activity
  + 6 more...
.platelet alpha granule lumen
.basolateral plasma membrane
.cell surface
  + 5 more...
3 EBI-641237,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
4 EBI-641237,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
5 EBI-641237,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
6 EBI-641237,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
7 EBI-641237,EBI-1026476 RASA1  
  .regulation of RNA metabolic process
.blood vessel morphogenesis
.ephrin receptor signaling pathway
  + 14 more...
.GTPase binding
.potassium channel inhibitor activity
.receptor binding
  + 2 more...
.intrinsic component of the cytoplasmic side of the plasma membrane
.cytosol
.cytoplasm
.ruffle
8 EBI-641237,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
9 EBI-641237,EBI-696162 PTEN  
  .positive regulation of apoptotic signaling pathway
.negative regulation of synaptic vesicle clustering
.positive regulation of excitatory postsynaptic membrane potential
  + 91 more...
.phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
.inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
.PDZ domain binding
  + 10 more...
.postsynaptic membrane
.Schmidt-Lanterman incisure
.dendritic spine
  + 12 more...
10 EBI-641237,EBI-2266035 PTPN12  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.SH3 domain binding
.non-membrane spanning protein tyrosine phosphatase activity
.cell projection
.cell junction
.plasma membrane
  + 3 more...
11 EBI-641237,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
12 EBI-641237,EBI-2264500 PTPRJ  
  .negative regulation of receptor activity
.contact inhibition
.negative regulation of protein kinase B signaling
  + 21 more...
.delta-catenin binding
.mitogen-activated protein kinase binding
.gamma-catenin binding
  + 5 more...
.extracellular exosome
.ruffle membrane
.cell junction
  + 6 more...
13 EBI-641237,EBI-726214 SLA  
  .positive regulation of signal transduction .SH3/SH2 adaptor activity .endosome
14 EBI-641237,EBI-970191 GRB7  
  .leukocyte migration
.stress granule assembly
.positive regulation of cell migration
  + 4 more...
.identical protein binding
.phosphatidylinositol binding
.protein kinase binding
  + 2 more...
.cell projection
.cytoplasmic stress granule
.focal adhesion
  + 2 more...
15 EBI-641237,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
16 EBI-641237,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
blood16
bone167
bone marrow20
brain40
connective tissue53
ear62
embryonic tissue56
esophagus49
eye90
heart67
intestine81
kidney66
larynx127
liver4
lung65
lymph node11
mammary gland52
mouth15
muscle28
nerve321
ovary118
pancreas74
placenta42
prostate42
salivary gland49
skin80
spleen93
stomach62
testis45
thyroid107
umbilical cord72
uterus112
vascular19
Health State
TissuesTPM*
normal61
bladder carcinoma284
breast (mammary gland) tumor10
chondrosarcoma132
colorectal tumor35
esophageal tumor57
gastrointestinal tumor50
germ cell tumor64
glioma18
head and neck tumor74
kidney tumor116
liver tumor10
lung tumor19
non-neoplasia51
ovarian tumor65
pancreatic tumor85
primitive neuroectodermal tumor of the CNS94
prostate cancer9
skin tumor15
uterine tumor122
Developmental Stage
TissuesTPM*
adult74
embryoid body157
blastocyst16
neonate32
fetus50
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue83.4
adrenal gland24.4
appendix27.9
cerebral cortex11.6
colon18.3
duodenum10.4
esophagus22.6
gallbladder146.3
heart muscle32.2
kidney29.2
liver8
lung51.1
lymph node27.4
ovary83.6
pancreas9.4
placenta94.9
prostate27.4
salivary gland10
skin23
small intestine12
spleen32.4
stomach11.1
testis23.5
thyroid gland28.7
urinary bladder65.6
Tissues
TissuesExpression level
breastMedium
cerebral cortexMedium
endometrium 1Medium
epididymisLow
kidneyMedium
oral mucosaLow
ovaryMedium
parathyroid glandLow
placentaMedium
prostateLow
skin 1High
soft tissue 1Low
soft tissue 2Low
stomach 1Medium
stomach 2Medium
testisMedium
tonsilLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#131440, phenotype) Myeloproliferative disorder, chronic, with eosinophiliaOMIM
2(*173410, gene) Platelet-derived growth factor receptor, beta; PDGFRBOMIM
3(%228550, phenotype) Fibromatosis, congenital generalized; CGFOMIM
4(#601626, phenotype) Leukemia, acute myeloid; AMLOMIM
5(#607785, phenotype) Juvenile myelomonocytic leukemia; JMMLOMIM
6Myeloproliferative disorder;acute myelogenous leukemia;chronic myelomonocytic leukemia;chronic myeloid leukemiaCGP


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