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> Protein (NX_P09769)
Protein (NX_P09769)
Protein
Gene SymbolFGR to neXtProt (NX_P09769)
DescriptionTyrosine-protein kinase Fgr
Chromosome1
Location1p36.11 (27938575 ~ 27961788) to Ensembl
Sequene Features : Isoforms 1, Variants 59, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to peptide hormone stimulus
.defense response to Gram-positive bacterium
.regulation of phagocytosis
  + 22 more...
.Fc-gamma receptor I complex binding
.immunoglobulin receptor binding
.protein kinase binding
  + 4 more...
.extracellular exosome
.ruffle membrane
.extrinsic component of cytoplasmic side of plasma membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 59 6
2014-09-19protein level
1 38 6
2014-05-27protein level
1 38 8
2014-02-25protein level
1 37 8
2013-12-09protein level
1 35 8
2013-11-01protein level
1 30 7
2013-09-12protein level
1 30 7
2013-08-17protein level
1 30 7
2013-07-15protein level
1 19 7
2013-06-11protein level
1 19 7
2013-02-12protein level
1 11 11
2012-12-20protein level
1 11 11
2012-10-30protein level
1 13 11
2012-10-07protein level
1 13 11
2012-08-24protein level
1 8 11
2012-07-28protein level
1 8 11
2012-06-08protein level
1 9 11
2012-05-07protein level
1 9 11
2012-04-10protein level
1 9 11
2012-01-13protein level
1 7 11
2011-12-20protein level
1 7 11
2011-11-11protein level
1 7 10
2011-08-23protein level
1 6 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P09769-1
24 0 2 59440.3772
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1383732,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-1383732,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-1383732,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
4 EBI-1383732,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
5 EBI-1383732,EBI-79934 ALOX5  
  .lipoxin metabolic process
.small molecule metabolic process
.lipoxygenase pathway
  + 4 more...
.iron ion binding
.arachidonate 5-lipoxygenase activity
.nuclear membrane
.nuclear matrix
.cytosol
  + 3 more...
6 EBI-1383732,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
7 EBI-1383732,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
blood458
bone13
bone marrow20
brain15
connective tissue46
esophagus49
heart44
intestine8
kidney18
liver14
lung71
lymph203
lymph node33
mammary gland6
mouth30
muscle18
ovary9
pharynx24
placenta42
spleen655
stomach10
thymus50
trachea19
uterus12
vascular19
Health State
TissuesTPM*
normal44
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor8
esophageal tumor57
glioma27
head and neck tumor14
kidney tumor43
leukemia328
liver tumor10
lymphoma124
non-neoplasia62
Developmental Stage
TissuesTPM*
adult35
neonate96
fetus17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.1
adrenal gland4
appendix68.1
bone marrow128
cerebral cortex2.4
colon5.1
duodenum3.5
esophagus6.1
gallbladder16.8
heart muscle2.7
kidney2.4
liver4.7
lung34.6
lymph node30.4
ovary1.6
pancreas2.7
placenta8
prostate3.1
salivary gland2.8
skin3.7
small intestine6
spleen79.3
stomach5.1
testis2.5
thyroid gland2.9
urinary bladder16.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164940, gene) Gardner-rasheed feline sarcoma viral oncogene homolog; FGROMIM


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