Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P09874)
Protein (NX_P09874)
Protein
Gene SymbolPARP1 to neXtProt (NX_P09874)
DescriptionPoly [ADP-ribose] polymerase 1
Chromosome1
Location1q42.12 (226548392 ~ 226595780) to Ensembl
Sequene Features : Isoforms 1, Variants 145, PTMs 49 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription regulatory region DNA binding
.cellular response to superoxide
.protein poly-ADP-ribosylation
  + 22 more...
.NAD binding
.protein N-terminus binding
.poly(A) RNA binding
  + 7 more...
.membrane
.nucleolus
.transcription factor complex
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 145 49
2014-09-19protein level
1 106 49
2014-05-27protein level
1 106 49
2014-02-25protein level
1 105 49
2013-12-09protein level
1 77 49
2013-11-01protein level
1 74 33
2013-09-12protein level
1 74 33
2013-08-17protein level
1 74 33
2013-07-15protein level
1 55 30
2013-06-11protein level
1 55 30
2013-02-12protein level
1 34 29
2012-12-20protein level
1 34 29
2012-10-30protein level
1 37 29
2012-10-07protein level
1 37 29
2012-08-24protein level
1 28 29
2012-07-28protein level
1 28 29
2012-06-08protein level
1 46 29
2012-05-07protein level
1 46 29
2012-04-10protein level
1 46 29
2012-01-13protein level
1 37 29
2011-12-20protein level
1 37 29
2011-11-11protein level
1 37 26
2011-08-23protein level
1 37 25
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P09874-1
45 0 0 113012.0713
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-355676,EBI-1045459 SNAI1  
  .regulation of tight junction assembly
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.Notch signaling involved in heart development
  + 16 more...
.metal ion binding
.kinase binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleus
2 EBI-355676,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-355676,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
4 EBI-355676,EBI-79704 ERG  
  .cell differentiation
.cell proliferation
.multicellular organismal development
  + 4 more...
.sequence-specific DNA binding
.signal transducer activity
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.ribonucleoprotein complex
.cytoplasm
.nucleus
5 EBI-355676,EBI-947466 XRCC1  
  .response to drug
.hippocampus development
.response to organic substance
  + 4 more...
.enzyme binding
.damaged DNA binding
.nucleoplasm
.nucleus
6 EBI-355676,EBI-1172054 CEBPA  
  .cellular response to organic cyclic compound
.cellular response to lithium ion
.lipid homeostasis
  + 34 more...
.transcription regulatory region DNA binding
.protein homodimerization activity
.kinase binding
  + 8 more...
.Rb-E2F complex
.nuclear matrix
.nucleolus
.nucleus
7 EBI-355676,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
8 EBI-355676,EBI-448924 E2F1  
  .regulation of G1/S transition of mitotic cell cycle
.lens fiber cell apoptotic process
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.Rb-E2F complex
.cytoplasm
.nucleoplasm
.nucleus
9 EBI-355676,EBI-3915542 IL24  
  .cellular response to interleukin-4
.cellular response to lipopolysaccharide
.positive regulation of JAK-STAT cascade
  + 11 more...
.cytokine activity .endoplasmic reticulum
.extracellular space
10 EBI-355676,EBI-368417 WRN  
  .nucleic acid phosphodiester bond hydrolysis
.cellular response to gamma radiation
.positive regulation of hydrolase activity
  + 23 more...
.G-quadruplex DNA binding
.ATP-dependent 3'-5' DNA helicase activity
.3'-5' DNA helicase activity
  + 15 more...
.centrosome
.nucleolus
.nucleoplasm
11 EBI-355676,EBI-950016 ZNF423  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.positive regulation of BMP signaling pathway
  + 4 more...
.metal ion binding
.DNA binding
.nucleus
12 EBI-355676,EBI-847814 APTX  
  .polynucleotide 3' dephosphorylation
.nucleic acid phosphodiester bond hydrolysis
.response to hydrogen peroxide
  + 6 more...
.phosphoprotein binding
.protein N-terminus binding
.metal ion binding
  + 7 more...
.cytoplasm
.nucleolus
.nucleoplasm
  + 2 more...
13 EBI-355676,EBI-1256044 APLF  
  .nucleic acid phosphodiester bond hydrolysis
.positive regulation of DNA ligation
.regulation of isotype switching
  + 3 more...
.metal ion binding
.3'-5' exonuclease activity
.endodeoxyribonuclease activity
  + 2 more...
.site of double-strand break
.cytosol
.nucleoplasm
.nucleus
14 EBI-355676,EBI-473160 PIAS4  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.positive regulation of keratinocyte apoptotic process
.negative regulation of transcription, DNA-templated
  + 8 more...
.SUMO ligase activity
.ubiquitin protein ligase binding
.SUMO transferase activity
  + 3 more...
.PML body
.nuclear matrix
.cytoplasm
  + 2 more...
15 EBI-355676,EBI-8502288 OARD1  
  .purine nucleoside metabolic process .deacetylase activity
.purine nucleoside binding
.N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland151
ascites75
bladder200
blood106
bone83
bone marrow41
brain197
cervix164
connective tissue80
ear62
embryonic tissue375
esophagus148
eye205
heart100
intestine211
kidney118
larynx170
liver136
lung143
lymph857
lymph node467
mammary gland132
mouth181
muscle169
nerve193
ovary157
pancreas196
parathyroid291
pharynx98
pituitary gland181
placenta141
prostate189
skin223
spleen74
stomach20
testis271
thymus112
thyroid42
tonsil352
trachea366
uterus155
vascular96
Health State
TissuesTPM*
normal180
adrenal tumor237
bladder carcinoma113
breast (mammary gland) tumor204
cervical tumor231
chondrosarcoma120
colorectal tumor311
esophageal tumor173
gastrointestinal tumor101
germ cell tumor357
glioma37
head and neck tumor134
kidney tumor159
leukemia127
liver tumor104
lung tumor145
lymphoma720
non-neoplasia165
ovarian tumor144
pancreatic tumor85
primitive neuroectodermal tumor of the CNS204
prostate cancer279
retinoblastoma409
skin tumor335
soft tissue/muscle tissue tumor215
uterine tumor88
Developmental Stage
TissuesTPM*
adult140
embryoid body314
blastocyst602
neonate64
fetus150
infant212
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.8
adrenal gland23.4
appendix58.2
bone marrow21.2
cerebral cortex46.8
colon31
duodenum24.9
esophagus27.8
gallbladder22.2
heart muscle37.1
kidney22.9
liver20.8
lung24.5
lymph node115.3
ovary25.6
pancreas18.6
placenta50.2
prostate35.7
salivary gland19.6
skin19.7
small intestine26.4
spleen55.3
stomach27.5
testis47
thyroid gland28.9
urinary bladder42.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverLow
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1High
soft tissue 2Low
spleenHigh
stomach 1Medium
stomach 2Low
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*173870, gene) Poly(adp-ribose) polymerase 1; PARP1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center