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> Protein (NX_P0CG48)
Protein (NX_P0CG48)
Protein
Gene SymbolUBC to neXtProt (NX_P0CG48)
DescriptionPolyubiquitin-C
Chromosome12
Location12q24.31 (125396150 ~ 125401914) to Ensembl
Sequene Features : Isoforms 1, Variants 58, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 58 9
2014-09-19protein level
1 35 9
2014-05-27protein level
1 35 8
2014-02-25protein level
1 35 8
2013-12-09protein level
1 33 8
2013-11-01protein level
1 32 8
2013-09-12protein level
1 32 8
2013-08-17protein level
1 32 8
2013-07-15protein level
1 19 8
2013-06-11protein level
1 19 8
2013-02-12protein level
1 3 12
2012-12-20protein level
1 4 12
2012-10-30protein level
1 5 12
2012-10-07protein level
1 5 19
2012-08-24protein level
1 2 19
2012-07-28protein level
1 2 19
2012-06-08protein level
1 6 19
2012-05-07protein level
1 6 19
2012-04-10protein level
1 6 19
2012-01-13protein level
1 7 19
2011-12-20protein level
1 7 19
2011-11-11protein level
1 7 19
2011-08-23protein level
1 7 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P0CG48-1
0 0 44 76991.3076
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3390054,EBI-310968 ASAP2  
  .positive regulation of catalytic activity .zinc ion binding
.enzyme activator activity
.GTPase activator activity
.Golgi cisterna membrane
.plasma membrane
2 EBI-3390054,EBI-358684 MAP3K7  
  .negative regulation of apoptotic signaling pathway
.regulation of reactive oxygen species metabolic process
.negative regulation of ripoptosome assembly involved in necroptotic process
  + 37 more...
.scaffold protein binding
.ATP binding
.MAP kinase kinase kinase activity
  + 4 more...
.endosome membrane
.plasma membrane
.cytosol
  + 4 more...
3 EBI-3390054,EBI-716083 DENR  
  .ribosome disassembly
.IRES-dependent translational initiation
.formation of translation preinitiation complex
.translation initiation factor activity .N/A
4 EBI-3390054,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
5 EBI-3390054,EBI-1001438 BUB1B  
  .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.cell division
  + 10 more...
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.spindle midzone
.perinuclear region of cytoplasm
.cytosol
  + 7 more...
6 EBI-3390054,EBI-8028844 ZFAND5  
  .face development
.smooth muscle tissue development
.skeletal system morphogenesis
  + 5 more...
.zinc ion binding
.DNA binding
.cytoplasm
7 EBI-3390054,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
8 EBI-3390054,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
9 EBI-3390054,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
10 EBI-3390054,EBI-444308 CDK1  
  .cellular response to hydrogen peroxide
.positive regulation of cardiac muscle cell proliferation
.ventricular cardiac muscle cell development
  + 69 more...
.histone kinase activity
.RNA polymerase II carboxy-terminal domain kinase activity
.ATP binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.midbody
  + 8 more...
11 EBI-3390054,EBI-355676 PARP1  
  .positive regulation of transcription regulatory region DNA binding
.cellular response to superoxide
.protein poly-ADP-ribosylation
  + 22 more...
.NAD binding
.protein N-terminus binding
.poly(A) RNA binding
  + 7 more...
.membrane
.nucleolus
.transcription factor complex
  + 3 more...
12 EBI-3390054,EBI-1383528 PRKCA  
  .positive regulation of dense core granule biogenesis
.intrinsic apoptotic signaling pathway
.apoptotic signaling pathway
  + 56 more...
.histone kinase activity (H3-T6 specific)
.enzyme binding
.zinc ion binding
  + 5 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical part of cell
  + 10 more...
13 EBI-3390054,EBI-3904795 ADRBK1  
  .cardiac muscle contraction
.neurotrophin TRK receptor signaling pathway
.viral entry into host cell
  + 17 more...
.beta-adrenergic receptor kinase activity
.Edg-2 lysophosphatidic acid receptor binding
.alpha-2A adrenergic receptor binding
  + 3 more...
.primary cilium
.membrane
.plasma membrane
  + 2 more...
14 EBI-3390054,EBI-307386 NFKBIA  
  .nucleotide-binding oligomerization domain containing 2 signaling pathway
.nucleotide-binding oligomerization domain containing 1 signaling pathway
.cellular response to cold
  + 39 more...
.NF-kappaB binding
.identical protein binding
.ubiquitin protein ligase binding
  + 3 more...
.I-kappaB/NF-kappaB complex
.plasma membrane
.cytosol
  + 2 more...
15 EBI-3390054,EBI-2341576 BMI1  
  .positive regulation of ubiquitin-protein transferase activity
.positive regulation of fibroblast proliferation
.cellular protein metabolic process
  + 8 more...
.RING-like zinc finger domain binding
.zinc ion binding
.PRC1 complex
.PcG protein complex
.cytoplasm
  + 3 more...
16 EBI-3390054,EBI-2129767 PCGF2  
  .negative regulation of apoptotic signaling pathway
.cellular response to hydrogen peroxide
.embryonic skeletal system morphogenesis
  + 8 more...
.zinc ion binding
.ubiquitin-protein transferase activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.PRC1 complex
.PcG protein complex
.nuclear body
  + 4 more...
17 EBI-3390054,EBI-7886448 LEPR  
  .negative regulation of hydrolase activity
.negative regulation of gluconeogenesis
.cholesterol metabolic process
  + 3 more...
.identical protein binding
.cytokine receptor activity
.transmembrane signaling receptor activity
.receptor complex
.integral component of membrane
.plasma membrane
.extracellular region
18 EBI-3390054,EBI-946046 ATXN3  
  .cellular response to misfolded protein
.protein K48-linked deubiquitination
.protein K63-linked deubiquitination
  + 14 more...
.Lys48-specific deubiquitinase activity
.Lys63-specific deubiquitinase activity
.ATPase binding
  + 4 more...
.nuclear inclusion body
.mitochondrial membrane
.nuclear matrix
  + 5 more...
19 EBI-3390054,EBI-954531 RAD23B  
  .proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
.spermatogenesis
  + 4 more...
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.XPC complex
.cytoplasm
.nucleoplasm
  + 2 more...
20 EBI-3390054,EBI-359318 PSMD4  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 21 more...
.poly(A) RNA binding
.identical protein binding
.proteasome accessory complex
.proteasome regulatory particle, base subcomplex
.cytosol
  + 3 more...
21 EBI-3390054,EBI-358143 RAP1B  
  .negative regulation of synaptic vesicle exocytosis
.regulation of establishment of cell polarity
.regulation of cell junction assembly
  + 9 more...
.protein complex binding
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.membrane
.cell-cell junction
  + 4 more...
22 EBI-3390054,EBI-517127 XIAP  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.positive regulation of protein linear polyubiquitination
.intrinsic apoptotic signaling pathway
  + 15 more...
.ubiquitin protein ligase activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
23 EBI-3390054,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
24 EBI-3390054,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
25 EBI-3390054,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
26 EBI-3390054,EBI-2696013 KLF5  
  .cellular response to peptide
.cellular response to organic cyclic compound
.intestinal epithelial cell development
  + 9 more...
.metal ion binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.intracellular membrane-bounded organelle
.plasma membrane
.Golgi apparatus
  + 2 more...
27 EBI-3390054,EBI-3905796 NFATC4  
  .positive regulation of apoptotic signaling pathway
.cellular response to lithium ion
.muscle cell development
  + 11 more...
.transcription coactivator activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.intermediate filament cytoskeleton
.cytosol
.cytoplasm
  + 2 more...
28 EBI-3390054,EBI-374260 ELAVL1  
  .regulation of stem cell maintenance
.3'-UTR-mediated mRNA stabilization
.mRNA stabilization
  + 3 more...
.poly(A) RNA binding
.mRNA 3'-UTR AU-rich region binding
.protein kinase binding
  + 6 more...
.membrane
.cytosol
.cytoplasm
  + 2 more...
29 EBI-3390054,EBI-954387 ADRM1  
  .proteasome assembly
.positive regulation of endopeptidase activity
.transcription elongation from RNA polymerase II promoter
.proteasome binding
.endopeptidase activator activity
.protease binding
.membrane
.integral component of plasma membrane
.plasma membrane
  + 3 more...
30 EBI-3390054,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
31 EBI-3390054,EBI-1755174 DTX1  
  .regulation of nucleic acid-templated transcription
.negative regulation of neuron differentiation
.negative regulation of T cell differentiation
  + 7 more...
.ubiquitin protein ligase binding
.ligase activity
.zinc ion binding
  + 2 more...
.cytosol
.cytoplasm
.nucleus
32 EBI-3390054,EBI-752324 RYBP  
  .histone H2A monoubiquitination
.multicellular organismal development
.apoptotic process
  + 2 more...
.zinc ion binding
.transcription corepressor activity
.DNA binding
.cytoplasm
.nucleoplasm
33 EBI-3390054,EBI-752333 STAM  
  .regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.membrane organization
  + 6 more...
.SH3/SH2 adaptor activity .early endosome membrane
.cytosol
34 EBI-3390054,EBI-346595 SH3KBP1  
  .negative regulation of epidermal growth factor receptor signaling pathway
.cell migration
.regulation of cell shape
  + 5 more...
.N/A .synapse
.neuron projection
.cytoplasmic vesicle membrane
  + 5 more...
35 EBI-3390054,EBI-3916363 RDH12  
  .photoreceptor cell maintenance
.retinol metabolic process
.phototransduction, visible light
  + 2 more...
.retinol dehydrogenase activity .photoreceptor inner segment membrane
.intracellular
36 EBI-3390054,EBI-7331284 CSF3R  
  .amelogenesis
.neutrophil chemotaxis
.signal transduction
  + 2 more...
.cytokine receptor activity
.receptor activity
.integral component of plasma membrane
.extracellular region
37 EBI-3390054,EBI-2880236 SENP3  
  .N/A .cysteine-type peptidase activity .MLL1 complex
.cytoplasm
.nucleolus
.nucleus
38 EBI-3390054,EBI-6968951 BCL2L12  
  .negative regulation of cellular senescence
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.positive regulation of transcription from RNA polymerase II promoter
.N/A .membrane
.nucleus
39 EBI-3390054,EBI-2341610 MARCH5  
  .negative regulation of cell aging
.positive regulation of mitochondrial fission
.regulation of mitochondrial fission
  + 3 more...
.GTPase binding
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.integral component of membrane
.membrane
.endoplasmic reticulum membrane
  + 2 more...
40 EBI-3390054,EBI-1047372 MALT1  
  .protein oligomerization
.nuclear export
.positive regulation of NF-kappaB transcription factor activity
  + 20 more...
.protein self-association
.peptidase activity
.signal transducer activity
  + 2 more...
.perinuclear region of cytoplasm
.protein complex
.CBM complex
  + 5 more...
41 EBI-3390054,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
42 EBI-3390054,EBI-527853 ZRANB1  
  .protein K33-linked deubiquitination
.protein deubiquitination involved in ubiquitin-dependent protein catabolic process
.protein K63-linked deubiquitination
  + 6 more...
.K63-linked polyubiquitin binding
.zinc ion binding
.ubiquitin-specific protease activity
.cytoplasm
.nucleoplasm
.nucleus
43 EBI-3390054,EBI-346622 ASAP1  
  .cilium morphogenesis
.organelle organization
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.GTPase activator activity
.membrane
.cytosol
44 EBI-3390054,EBI-741480 UBQLN1  
  .regulation of autophagic vacuole assembly
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.identical protein binding
.polyubiquitin binding
.kinase binding
.perinuclear region of cytoplasm
.protein complex
.aggresome
  + 6 more...
45 EBI-3390054,EBI-741774 POLI  
  .error-prone translesion synthesis
.translesion synthesis
.DNA repair
.DNA replication
.metal ion binding
.DNA-directed DNA polymerase activity
.damaged DNA binding
.intracellular membrane-bounded organelle
.nucleoplasm
.nucleus
.intracellular
46 EBI-3390054,EBI-1569435 ABCG2  
  .transmembrane transport
.urate metabolic process
.small molecule metabolic process
  + 6 more...
.protein homodimerization activity
.ATPase activity, coupled to transmembrane movement of substances
.heme transporter activity
  + 3 more...
.mitochondrial membrane
.integral component of membrane
.plasma membrane
  + 2 more...
47 EBI-3390054,EBI-2827270 POLH  
  .error-free translesion synthesis
.translesion synthesis
.response to UV-C
  + 5 more...
.metal ion binding
.DNA-directed DNA polymerase activity
.damaged DNA binding
.cytoplasm
.nucleoplasm
48 EBI-3390054,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
49 EBI-3390054,EBI-77848 SNX9  
  .membrane tubulation
.lipid tube assembly
.positive regulation of membrane protein ectodomain proteolysis
  + 11 more...
.Arp2/3 complex binding
.protein homodimerization activity
.phosphatidylinositol binding
  + 2 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic vesicle membrane
  + 7 more...
50 EBI-3390054,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
51 EBI-3390054,EBI-448104 MAP3K4  
  .positive regulation of p38MAPK cascade
.chorionic trophoblast cell differentiation
.positive regulation of JUN kinase activity
  + 8 more...
.metal ion binding
.ATP binding
.MAP kinase kinase kinase activity
.MAP kinase kinase activity
.perinuclear region of cytoplasm
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue2020
adrenal gland5403
ascites2209
bladder2511
blood3427
bone642
bone marrow1025
brain59
cervix2083
connective tissue4346
ear559
embryonic tissue295
esophagus248
eye272
heart234
intestine581
kidney218
larynx2173
liver394
lung445
lymph203
lymph node155
mammary gland1593
mouth256
muscle347
nerve1223
ovary541
pancreas758
pharynx270
pituitary gland605
placenta282
prostate464
salivary gland690
skin384
spleen112
stomach846
testis195
thymus125
thyroid1481
tonsil470
trachea38
umbilical cord653
uterus499
vascular232
Health State
TissuesTPM*
normal246
adrenal tumor948
bladder carcinoma796
breast (mammary gland) tumor1557
cervical tumor2000
chondrosarcoma1255
colorectal tumor799
esophageal tumor5566
gastrointestinal tumor1417
germ cell tumor4437
glioma2733
head and neck tumor724
kidney tumor2729
leukemia2138
liver tumor1635
lung tumor749
lymphoma664
non-neoplasia4346
ovarian tumor1115
pancreatic tumor895
primitive neuroectodermal tumor of the CNS3748
prostate cancer211
retinoblastoma710
skin tumor566
soft tissue/muscle tissue tumor702
uterine tumor1720
Developmental Stage
TissuesTPM*
adult630
embryoid body528
blastocyst341
neonate6469
fetus1640
infant2722
juvenile6531
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue803.4
adrenal gland797.5
appendix565.5
bone marrow1193.6
cerebral cortex599.4
colon702.3
duodenum418.6
esophagus1068.8
gallbladder989.9
heart muscle741.2
kidney548.4
liver684
lung755.2
lymph node608.5
ovary613.9
pancreas350.6
placenta651.3
prostate534.5
salivary gland656.6
skin615.9
small intestine601.9
spleen545.6
stomach463.7
testis895.4
thyroid gland640.6
urinary bladder774.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowLow
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumLow
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungLow
lymph nodeLow
nasopharynxLow
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineLow
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*191340, gene) Ubiquitin c; UBCOMIM


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